Non-invasive quantification of coronary vascular dysfunction for diagnosis and management of coronary artery disease

Clinical Quantification of Myocardial Blood Flow Using PET: Joint Position Paper of the SNMMI Cardiovascular Council and the ASNC

“…The purpose of this document is, first, to consolidate and update technical considerations for clinical quantification of MBF and myocardial flow reserve (MFR) from earlier documents 8 and, second, to summarize and update the scientific basis for their clinical application. 9,10 TECHNICAL CONSIDERATIONS…”

Enhanced Risk Stratification With Noninvasive Measurement of Coronary Flow Reserve Using Positron Emission Tomography

“…[1][2][3][4][5][6] Assessing CFR provides significantly greater separation of low-and high-risk subsets of patients compared with conventional single photon emission tomography or PET, imaging in which only relative tracer uptake is evaluated after exercise or pharmacological stress. Certainly, the traditional semiquantitative techniques used for many years for conventional single photon emission tomography and PET MPI have provided valuable diagnostic and prognostic information, particularly when extensive focal defects are identified on poststress images, which normalize on resting studies.…”

Role of Noninvasive Testing in the Clinical Evaluation of Women With Suspected Ischemic Heart Disease

“…165 One distinct advantage of stress PET MPI is the ability to calculate absolute blood flow across the coronary vessels, which leads to the calculation of PET MFR. 137,166 Damped PET MFR can augment MPI findings, particularly for those with normal or low-risk findings. 167 Evidence of diminished MFR (defined as <1.9-2.0) suggests underlying vascular dysfunction and may aid in the detection of microvascular CAD, which may be particularly helpful in the evaluation of women with more prevalent nonobstructive CAD.…”