Non-invasive quantification of hepatic fat fraction by fast 1.0, 1.5 and 3.0T MR imaging

Schuchmann, Sebastian; Weigel, Christiane; Albrecht, Lothar; Kirsch, Michael; Lemke, A.-J.; Lorenz, Gerd; Warzok, R; Hosten, Norbert

doi:10.1016/j.ejrad.2006.12.009

Cited by 54 publications

(40 citation statements)

References 24 publications

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“…Many previous studies using MRI were not calibrated through comparison with a phantom, and less reproducibility was obtained than with the technique described here [19][20][21][22][23]. In contrast with these previous studies, we compared MRI findings with optical image analysis data using software and found that measurements from the two modalities were linearly related and highly correlated.…”

Section: Discussioncontrasting

confidence: 64%

“…However, this preparation is the only indispensable step for accurate quantification. Recent studies have demonstrated that a technique using selective saturation with a 3.0-T MRI scanner quantified liver fat content relatively well [21,33], but 3.0-T MRI scanners are not commonly available at present.…”

Section: Discussionmentioning

confidence: 99%

“…Of all MRI techniques, the double-echo chemical shift gradient-echo technique is the most sensitive to detect fat [14,15,[17][18][19][20][21][22][23], and many studies have used this technique to evaluate hepatic steatosis. However, these studies lacked a basic experiment using a phantom or quantitative evaluation in the histopathological assessment of hepatic fat content, or a prospective study design, and were semiquantitative in nature because of the inclusion of a classification of the fat content rate.…”

Section: Introductionmentioning

confidence: 99%

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Accurate and simple method for quantification of hepatic fat content using magnetic resonance imaging: a prospective study in biopsy-proven nonalcoholic fatty liver disease

et al. 2010

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Section: Discussioncontrasting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Accurate and simple method for quantification of hepatic fat content using magnetic resonance imaging: a prospective study in biopsy-proven nonalcoholic fatty liver disease

et al. 2010

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“…With the modified Dixon method, it is possible to detect mild liver steatosis using dual-echo fast GRE sequence imaging (4,(8)(9)(10).…”

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confidence: 99%

Diffusion‐weighted MRI of fatty liver

Poyraz

Onur

Kocakoç

et al. 2011

Magnetic Resonance Imaging

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Purpose: To investigate the effect of fat infiltration on the apparent diffusion coefficient (ADC) of liver, and assess the relationship between ADC and hepatic fat fraction (HFF).Materials and Methods: MRI scans of 120 consecutive patients were included in this retrospective study. Of these, 42 patients were included in the fatty liver group and 78 in the control group. ADC values were measured from a pair of diffusion-weighted (DW) images (b ¼ 0 mm 2 /s and 1000 mm 2 /s). HFFs were measured using T1W GRE dual-echo images. The difference between the ADCs of the two groups was assessed with the t-test. The relationship between HFF and ADC was determined using linear regression analysis and the Pearson correlation coefficient (r).Results: Mean HFFs were 0.85 6 2.86 and 13.67 6 8.62 in the control and fatty liver groups, respectively. The mean ADC of fatty liver group 1.20 6 0.22 Â 10 À3 mm 2 /s was significantly lower than that of the control group 1.32 6 0.23 Â 10 À3 mm 2 /s (P ¼ 0.02). Linear regression analysis revealed an inverse relationship between ADC and HFF (r ¼ À0.39, P < 0.0001).Conclusion: ADC significantly decreases in patients with >5% HFF, and ADC and HFF exhibit an inverse relationship.

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“…Ayrıca bu çalışma göstermiştir ki, US ile MR arasındaki bu uyum yağlanma yokluğunda da yüksektir. Bizim çalışmamızda MRG sinyal şiddeti ile ölçülen doku yağ oranı için kullandığımız eşik değer %5.1 olup değişik çalışmalarda %5, %5.1, %5.56, %8, %17 gibi farklı eşik değerler biyopsi ve MRS ile karşılaştırılmış ve iyi korelasyon göstermiştir [9,13,18,19]. Yine de yağlanmanın MR derecesi ile US derecesi arasında birebir denklik olmaması beklenti dahilindedir.…”

Section: Discussionunclassified

Comparison of ultrasonography and dual echo magnetic resonance imaging in the diagnosis of fatty liver disease

Öztoprak¹,

Atalar²,

Alagözlü³

2016

Pau Med J

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ÖzetAmaç: Yağlı karaciğer hastalığı toplumun yaklaşık üçte birini etkileyen bir kronik karaciğer hastalığıdır. Hepatositler içinde yağ birikimi ile karakterizedir. Yağlı karaciğer hastalığı basit steatozdan, steatohepatit, fibozis ve siroza kadar giden geniş bir hastalık spektrumunu kapsar. Yağlı karaciğer hastalığının radyolojik tanısında ultrasonografi, bilgisayarlı tomografi ve manyetik resonans görüntüleme kullanılabilir. Bu çalışmanın amacı yağlı karaciğer hastalığının tanısında ultrason ve dual eko manyetik resonans görüntülemeyi karşılaştırmaktır. Gereç ve yöntem: İncelenen 179 hastadan 112'sinin aynı ay içinde elde edilmiş manyetik rezonans görüntüleri ve ultrason raporları retrospektif olarak değerlendirildi. Kimyasal kayma etkisine dayalı dual eko iç-dış fazlı manyetik rezonans görüntüleri karaciğer yağlanmasının varlığı, derecesi ve yaygınlığı bakımından ultrason raporları ile karşılaştırıldı. Hepatik yağ oranını hesaplamak için iç ve dış fazlı görüntülerin sinyal şiddeti farkına dayalı bir formül kullanıldı. Bulgular:Ultrason ile 112 hastanın 55'inde, dual eko manyetik rezonans görüntüleme ile 112 hastanın 62'sinde yağlı karaciğer tespit edildi. Yağlanmanın tespitinde iki teknik arasındaki fark istatistiksel olarak anlamsızdı (p=0.839). Ancak, karaciğer yağlanmasının derecelendirmesinde ve karaciğer tutulumunun heterojenitesini belirlemede ultrason ile manyetik rezonans görüntüleme arasında istatistiksel olarak anlamlı fark mevcuttu (sırasıyla, p=0.004 ve p<0.001). Sonuç: Yağlı karaciğer hastalığının tanısında ultrason pratik bir tanı yöntemi olarak önemini korumaktadır. Ancak, yağlanmanın derecesini ve yaygınlığını tespit etmede dual-eko manyetik rezonans görüntülemeye göre başarısı düşüktür. Pam Tıp Derg 2016;9(3):140-147Anahtar sözcükler: Dual eko görüntüleme, iç faz dış faz görüntüleme, manyetik rezonans görüntüleme, ultrasonografi, yağlı karaciğer hastalığı. AbstractPurpose: Fatty liver disease is a common cause of chronic liver disease affecting approximately one-third of the population. It is characterized by fatty infiltration of hepatocytes. It represents a spectrum of diseases including simple steatosis, steatohepatitis, fibrosis and cirrhosis. Ultrasonography, computerized tomography and magnetic resonance imaging can be used for the radiologic diagnosis of fatty liver. The aim of this study is to compare the diagnostic accuracy of Ultrasonography and dual echo magnetic resonance imaging in detecting fatty liver. Materials and methods:Magnetic resonance images and ultrasound reports obtained in the same 30 days of 112 patients out of 179 patients were evaluated retrospectively. Chemical shift-based dual echo in-phase and out-of-phase images were compared to sonographic findings for the presence of hepatic steatosis, the degree of steatosis and the extend of liver involvement. Signal intensity differences in in-and out-of-phase images were calculated to quantify the fat fraction in the liver. Results: Out of 112 patients, 55 and 62 were diagnosed with fatty liver with ultrasound and magneti...

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Non-invasive quantification of hepatic fat fraction by fast 1.0, 1.5 and 3.0T MR imaging

Cited by 54 publications

References 24 publications

Accurate and simple method for quantification of hepatic fat content using magnetic resonance imaging: a prospective study in biopsy-proven nonalcoholic fatty liver disease

Accurate and simple method for quantification of hepatic fat content using magnetic resonance imaging: a prospective study in biopsy-proven nonalcoholic fatty liver disease

Diffusion‐weighted MRI of fatty liver

Comparison of ultrasonography and dual echo magnetic resonance imaging in the diagnosis of fatty liver disease

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