Non-invasive quantitative analysis of human blood components in renal three items using spectral compensation method based on spectral data and component content correlation

Wang, Kang; Wang, Dan; Li, Gang

doi:10.1016/j.cmpb.2022.107210

Computer Methods and Programs in Biomedicine

2022

DOI: 10.1016/j.cmpb.2022.107210

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Non-invasive quantitative analysis of human blood components in renal three items using spectral compensation method based on spectral data and component content correlation

Kang Wang¹,

Dan Wang²,

Gang Li³

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Cited by 2 publications

References 26 publications

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Simultaneous Detection of Biomarkers in Urine Using a Multicalibration Potentiometric Sensing Array Combined with a Portable Analyzer

Cheng,

Wang,

Zuo

et al. 2024

Anal. Chem.

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Domestic monitoring devices make real-time and long-term health monitoring possible, allowing people to track their health status regularly. Uric acid (UA), creatinine, and urea in urine are three important biomarkers for various diseases, especially kidney diseases. This work proposed a 10-channel potentiometric sensing array containing a UA electrode group, a creatinine electrode group, a urea electrode group, a pH electrode group, and one pair of reference channels, which could be connected with a portable potentiometric analyzer, realizing the simultaneous detection of UA, creatinine, urea, and pH in urine. The prepared Pt/carbon nanotubes (CNTs)-uricase, creatinine deiminase, Au@urease, and polyaniline were employed as the sensing materials, showing responses to four targets with high sensitivity and selectivity. To improve the accuracy of domestic monitoring, a calibration channel was integrated into each electrode group to calibrate the basic potential of the sensing channels, and the influences of pH and temperature on the responses were investigated through the pH electrode group and an external temperature probe to calibrate the slope and intercept. With the preset of the deduced calibration parameters and computational formula for the four targets in the analyzer in Lab Mode, the concentrations of UA, creatinine, and urea and the pH of the human urine samples were directly displayed on the screen of the analyzer in Practical Mode. The agreement of these results with those obtained from commercial kits and pH meters reveals the high potential of these methods for developing domestic devices to facilitate health monitoring.

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Simultaneous Detection of Biomarkers in Urine Using a Multicalibration Potentiometric Sensing Array Combined with a Portable Analyzer

Cheng,

Wang,

Zuo

et al. 2024

Anal. Chem.

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Suppression of Odd Harmonic Interference in a Fast Digital Lock-in Amplifier Based on Square Wave Signal

Fan

Lan

et al. 2023

IEEE Trans. Instrum. Meas.

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Non-invasive quantitative analysis of human blood components in renal three items using spectral compensation method based on spectral data and component content correlation

Cited by 2 publications

References 26 publications

Simultaneous Detection of Biomarkers in Urine Using a Multicalibration Potentiometric Sensing Array Combined with a Portable Analyzer

Simultaneous Detection of Biomarkers in Urine Using a Multicalibration Potentiometric Sensing Array Combined with a Portable Analyzer

Suppression of Odd Harmonic Interference in a Fast Digital Lock-in Amplifier Based on Square Wave Signal

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