Non-Invasive Sampling Method for Detecting Chlamydia Trachomatis

Caul, E.O.; Paul, Ian; Milne, Judith; Crowley, Tessa

doi:10.1016/s0140-6736(88)90831-8

Cited by 24 publications

(15 citation statements)

References 3 publications

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“…In most studies of FVU, the conventional wisdom has been that concentrated specimens, such as those obtained in the early morning (16,17) or after a minimum of 1 h (2) or 4 h (9) of continence, are important for the detection of chlamydial infection in men and women. In the case of men's urine, Schwebke et al (8) reported that the sensitivity of EIA was not affected by the length of time since previous voiding, and Thomas et al (5) found that there was no loss in EIA sensitivity with specimens produced at a clinic visit compared to early morning specimens.…”

mentioning

confidence: 99%

Effect of time elapsed since previous voiding on the detection ofChlamydia trachomatis antigens in urine

Sellors

Chernesky

Pickard

et al. 1993

Eur. J. Clin. Microbiol. Infect. Dis.

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To determine if the time elapsed since previous voiding affects the sensitivity of an enzyme immunoassay (EIA) to detect Chlamydia trachomatis in urine, 882 women and 428 men were tested for chlamydial infection in urethral specimens by isolation in cell culture (women and men) and EIA with blocking confirmation (women only). Of the 36 women (4.1%) and 38 men (8.9%) who were positive for Chlamydia trachomatis in the urethra, 55.5% (20/36) and 81.6% (31/38) respectively were positive in the first void urine (FVU) sediment by confirmed EIA. In women the sensitivity of the EIA performed on FVU was 67.8% (19/28) if the urine had been in the bladder < 3 hours and decreased to 12.5% (1/8) if longer times had elapsed (odds ratio 13.7; 95% confidence interval 1.4 to 700.0) with no obvious confounding. In men a weaker association was present (odds ratio 2.7; 95% confidence interval 0.4 to 22.3). These findings should enable investigators to optimize the analysis of urine to diagnose chlamydial infections.

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mentioning

confidence: 99%

Effect of time elapsed since previous voiding on the detection ofChlamydia trachomatis antigens in urine

Sellors

Chernesky

Pickard

et al. 1993

Eur. J. Clin. Microbiol. Infect. Dis.

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“…Thus, urine samples were widely favored for some years 18 , instead of urethral and/or cervical samples 19,20 . During the 1990s, there have been changes as to which sample type(s) should be recommended.…”

Section: Which Sample Type(s) Should Be Analyzed?mentioning

confidence: 99%

“…Several studies over the decades have shown that the stability of C. trachomatis DNA enables samples to be transported by mail to a laboratory without loss in test sensitivity 18,22 . Such samples gave a higher detection rate than voided urine when both types of samples were mailed to the laboratory 23 .…”

Section: Which Sample Type(s) Should Be Analyzed?mentioning

confidence: 99%

Chlamydia trachomatis infections – a major concern for reproductive health. Where do we stand regarding epidemiology, pathogenesis, diagnosis and therapy?

Mårdh¹,

Novikova²

2001

The European Journal of Contraception & Reproductive Health

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The current article deals with the problem of distinguishing between relapse and reinfection of genital chlamydial infections due to the chronic character of such infections. The problem of detecting and treating chlamydial pelvic inflammatory disease is considered. Factors that may affect the clinical presentation of such infections, such as hormonal therapy, are also highlighted. Observations on novel manifestations of Chlamydia trachomatis infections, such as spontaneous abortion, prematurity and intrauterine infections as well as a statistical correlation of a certain serovar to cervical cancer, are described. The representivity of the data on infections with C. trachomatis monitored in national surveillance programs is questioned. The paper also elaborates on which type of sample, sample site and detection method may be optimal for the diagnosis of such infections in women. Whether to screen at clinics and self-sampling at home of specimens from an index case and a sexual partner to be mailed to a laboratory for testing is discussed. Whether or not females are more susceptible to genital chlamydial infections and their sequelae than males is also discussed. The effectiveness of recommended antibiotic regimens is considered, e.g. in relation to the recent detection of the existence of strains of C. trachomatis that show heterotypic resistance to drugs commonly used for their treatment.

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“…Testing urine samples in cell cultures was too insensitive, but the results of testing them by EIAs were much more encouraging 31,32 , even though some workers have not been over-enthusiastic about this non-invasive approach, particularly for asymptomatic men. Overall, however, there seems little doubt that testing the centrifuged deposit from a ® rst-catch urine sample is as sensitive as testing a urethral swab, assuming that the same test is applied to each 33 .…”

Section: Urines As Specimensmentioning

confidence: 99%

Tests for infection with Chlamydia trachomatis

Taylor‐Robinson

1996

Int J STD AIDS

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Non-Invasive Sampling Method for Detecting Chlamydia Trachomatis

Cited by 24 publications

References 3 publications

Effect of time elapsed since previous voiding on the detection ofChlamydia trachomatis antigens in urine

Effect of time elapsed since previous voiding on the detection ofChlamydia trachomatis antigens in urine

Chlamydia trachomatis infections – a major concern for reproductive health. Where do we stand regarding epidemiology, pathogenesis, diagnosis and therapy?

Tests for infection with Chlamydia trachomatis

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