Non-invasive single-trial detection of variable population spike responses in human somatosensory evoked potentials

Waterstraat, Gunnar; Scheuermann, Michaela; Curio, Gabriel

doi:10.1016/j.clinph.2015.12.005

Cited by 10 publications

(8 citation statements)

References 32 publications

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“…The increase of cortical population spiking activity evoked by median nerve stimulation was estimated as "signal-plus-noise"to-noise ratio (SNNR: ratio of signal-plus-noise amplitudes in a response window to noise-only amplitudes in a prestimulus window): Phase-insensitive hfSER components had a single-trial SNNR between 5.6 dB (subject S4) and 8.8 dB (subject S1). The SNNR in the present ultralow-noise single-channel MEG recordings was therefore mostly higher than in optimally projected low-noise multichannel scalp-EEG recordings: In previous eight-channel EEG data, 9 of 10 subjects had a SNNR of hfSERs below 5.1 dB (26). Critically, the SNNR of phase-insensitive hfSER components is not obtained from a standard average across responses (as in, e.g., ref.…”

Section: Significancementioning

confidence: 64%

“…even at the level of unaveraged single trials tainted by system noise (which, however, is exceptionally low for the present ultralownoise MEG system). Corroborating previous human scalp-EEG recordings (24,26), this detection of evoked ("added") hf-energy excludes a mere stimulus-driven phase reset of ongoing background HFO as sole generator of macroscopic hfSERs (25). The increase of cortical population spiking activity evoked by median nerve stimulation was estimated as "signal-plus-noise"to-noise ratio (SNNR: ratio of signal-plus-noise amplitudes in a response window to noise-only amplitudes in a prestimulus window): Phase-insensitive hfSER components had a single-trial SNNR between 5.6 dB (subject S4) and 8.8 dB (subject S1).…”

Section: Significancementioning

confidence: 99%

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Noninvasive neuromagnetic single-trial analysis of human neocortical population spikes

Waterstraat

Körber

Curio

2021

Proc. Natl. Acad. Sci. U.S.A.

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Neuronal spiking is commonly recorded by invasive sharp microelectrodes, whereas standard noninvasive macroapproaches (e.g., electroencephalography [EEG] and magnetoencephalography [MEG]) predominantly represent mass postsynaptic potentials. A notable exception are low-amplitude high-frequency (∼600 Hz) somatosensory EEG/MEG responses that can represent population spikes when averaged over hundreds of trials to raise the signal-to-noise ratio. Here, a recent leap in MEG technology—featuring a factor 10 reduction in white noise level compared with standard systems—is leveraged to establish an effective single-trial portrayal of evoked cortical population spike bursts in healthy human subjects. This time-resolved approach proved instrumental in revealing a significant trial-to-trial variability of burst amplitudes as well as time-correlated (∼10 s) fluctuations of burst response latencies. Thus, ultralow-noise MEG enables noninvasive single-trial analyses of human cortical population spikes concurrent with low-frequency mass postsynaptic activity and thereby could comprehensively characterize cortical processing, potentially also in diseases not amenable to invasive microelectrode recordings.

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Section: Significancementioning

confidence: 64%

Section: Significancementioning

confidence: 99%

Noninvasive neuromagnetic single-trial analysis of human neocortical population spikes

Waterstraat

Körber

Curio

2021

Proc. Natl. Acad. Sci. U.S.A.

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“…Brain oscillatory networks in 'classical' frequency bands (from 1 Hz up to 120 Hz) could also be contaminated by the band-pass filtering of transients, requiring an adequate pipeline for separation (Selesnick and Bayram 2009). High frequency oscillations (HFO, between 120Hz and 500 Hz) in the ripple and fast ripples bands (Urrestarazu et al 2006;Chaibi et al 2014) as well as physiological oscillations (Bragin et al 2010;Waterstraat et al 2016) Despiking could potentially be useful for other fields of neuroscience, where mixtures of transients and oscillations are present in the time series. For example, local field potentials present a mixture of oscillatory activity and sharp action potentials, and despiking could improve the investigation of correlations between LFP frequency bands and neuronal spiking (Mazzoni et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Despiking SEEG signals reveals dynamics of gamma band preictal activity

et al. 2017

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Interictal epileptiform discharges, or 'interictal spikes', are the hallmark of epilepsy. Still, there is growing evidence that oscillatory activity-whether in the gamma band (30-120 Hz) or at higher frequencies is another important marker of hyperexcitable tissues. A major difficulty arises from the fact that interictal spikes and oscillations overlap in the frequency domain. This hampers the correct delineation of the cortex producing pathological oscillations by simple filtering. Here, we propose a nonlinear technique for fitting the spike waveform in order to remove it, resulting in a 'despiked' signal. This strategy was first applied to simulated data inspired from real stereo-electroencephalographic (SEEG) signals, then to real data. We show that despiking leads to a better space-time-frequency analysis of the oscillatory part of the signal. Thus, in the real SEEG signals, the spatio-temporal maps show a buildup of gamma oscillations during the preictal period in the despiked signals, whereas in the original signals this activity is masked by spikes. Despiking is thus a promising venue for a better characterization of oscillatory activity in electrophysiology of epilepsy.

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“…Similar to our present data, these cortical HFO were followed by spike suppression and noticeable after hyperpolarisation. HFO were also identified by FFT analyses of somatosensory evoked potentials in humans (Curio et al, 1994;Waterstraat et al, 2016).…”

Section: Other Hfo Already Describedmentioning

confidence: 99%

Beta‐gamma burst stimulations of the inferior olive induce high‐frequency oscillations in the deep cerebellar nuclei

Cheron

Chéron

2018

Eur J of Neuroscience

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The cerebellum displays various sorts of rhythmic activities covering both low- and high-frequency oscillations. These cerebellar high-frequency oscillations were observed in the cerebellar cortex. Here, we hypothesised that not only is the cerebellar cortex a generator of high-frequency oscillations but also that the deep cerebellar nuclei may also play a similar role. Thus, we analysed local field potentials and single-unit activities in the deep cerebellar nuclei before, during and after electric stimulation in the inferior olive of awake mice. A high-frequency oscillation of 350 Hz triggered by the stimulation of the inferior olive, within the beta-gamma range, was observed in the deep cerebellar nuclei. The amplitude and frequency of the oscillation were independent of the frequency of stimulation. This oscillation emerged during the period of stimulation and persisted after the end of the stimulation. The oscillation coincided with the inhibition of deep cerebellar neurons. As the inhibition of the deep cerebellar nuclei is related to inhibitory inputs from Purkinje cells, we speculate that the oscillation represents the unmasking of the synchronous activation of another subtype of deep cerebellar neuronal subtype, devoid of GABA receptors and under the direct control of the climbing fibres from the inferior olive. Still, the mechanism sustaining this oscillation remains to be deciphered. Our study sheds new light on the role of the olivo-cerebellar loop as the final output control of the intercerebellar circuitry.

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Non-invasive single-trial detection of variable population spike responses in human somatosensory evoked potentials

Cited by 10 publications

References 32 publications

Noninvasive neuromagnetic single-trial analysis of human neocortical population spikes

Noninvasive neuromagnetic single-trial analysis of human neocortical population spikes

Despiking SEEG signals reveals dynamics of gamma band preictal activity

Beta‐gamma burst stimulations of the inferior olive induce high‐frequency oscillations in the deep cerebellar nuclei

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