Non-invasive techniques for assessing postoperative recurrence in Crohn's disease

Biancone, Livia; Onali, S.; Calabrese, Emma; Petruzziello, C.; Zorzi, Francesca; Condino, G.; Sica, Giuseppe; Pallone, Francesco

doi:10.1016/s1590-8658(08)60536-8

Cited by 44 publications

(33 citation statements)

References 40 publications

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“…As inflammation is linked to impaired intestinal barrier function [59] it is not surprising that a marker for inflammation might also be valuable as a marker for barrier function. Faecal calprotectin is, similar as α1-antitrypsin, used as marker in IBD [60], but the levels of calprotectin were below the detection limit of 10 mg/L in the studied patient group. This might indicate that in contrast to α1-antitrypsin, calprotectin is not a useful marker for subtle intestinal barrier problems, but more relevant in diseases like IBD with marked inflammation of the epithelial barrier function.…”

Section: Case Seriesmentioning

confidence: 72%

Clinical Studies Evaluating Effects of Probiotics on Parameters of Intestinal Barrier Function

Hemert¹,

Verwer²,

Schütz³

2013

AiM

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The intestinal barrier is important in preventing translocation of bacteria, toxins and antigens from the lumen of the gut into the body. Enhanced permeability, or gut leakiness, has been associated with different diseases. Probiotics can, strain-specifically, improve the epithelial barrier function. However, so far most researches have used cell lines or animal models due to the difficulty of measuring the effects of products on the epithelial barrier function in vivo in humans. Here a systematic literature search was performed to find articles addressing the effects of probiotics on the barrier function in human trials. The Pubmed database was searched (January 2013) to identify human in vivo studies with probiotic products in which parameters for epithelial barrier function were measured. In total 29 studies were identified, but patients, bacterial characteristics and methods to measure intestinal barrier function caused large heterogeneity among these studies. About half of the studies showed positive results of probiotics on the epithelial barrier function, indicating a clear potential of probiotics in this field. In a case series of 14 patients using Ecologic  825, a probiotic food supplement with known effect on epithelial barrier function, different markers of intestinal integrity improved significantly. Further studies in this field should consider strain(s), dose and duration of the probiotic supplementation as well as the markers used to measure epithelial barrier function. Besides the lactulose/mannitol test, zonulin and α1-antitrypsin might be valuable markers to measure epithelial barrier function in future experiments.

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Section: Case Seriesmentioning

confidence: 72%

Clinical Studies Evaluating Effects of Probiotics on Parameters of Intestinal Barrier Function

Hemert¹,

Verwer²,

Schütz³

2013

AiM

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“…11 As yet no simple diagnostic test has been validated against endoscopy in large populations to monitor for disease recurrence post-operatively.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Measurement of Fecal Calprotectin Improves Monitoring and Detection of Recurrence of Crohn's Disease After Surgery

et al. 2015

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and PV Desmond have no conflicts of interest to declare. P De Cruz has received travel grant support from Abbott and Schering-Plough. MA Kamm has acted as an advisor to Abbott and Janssen, has received research support from Abbott, and has acted as a speaker at symposiums sponsored by Abbott and Janssen. A Hamilton has received an educational grant from Abbott. D Liew has served on advisory boards and received research grants from Abbott. IC Lawrance has been on an advisory board for Abbott and Janssen, a speaker for Abbott and Janssen, and has held research and travel grants from Abbott and Janssen. JM Andrews has been an advisory board member for both Janssen and Abbott, spoken for both Abbott and Janssen, received research funds from both Abbott and Janssen, and received travel grants from both Abbott and Janssen. PA Bampton has been on advisory boards for Janssen and Abbott, has received research funding from Abbott, and travel sponsorship from both Abbott and Janssen. PR Gibson has received consulting fees from Abbott, Janssen, and Schering-Plough; research support from Abbott; and payments for lectures from Abbott and Janssen. FA Macrae has been on an advisory board to Janssen, has received travel grants from Abbott, and has received clinical research support from Janssen, Abbott and MSD. W Selby has been on an advisory board for Abbott. SJ Bell has received travel assistance from Abbott. SJ Brown has received travel support and speaker fees from both Abbott and Janssen. WR Connell has been on advisory board for Janssen and a speaker for Abbott and Janssen. AS Day has been an M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT advisor to Janssen. RB Gearry has been on an advisory board for Abbott and Janssen, a speaker for Abbott and Janssen, and held research, educational and travel grants from Abbott and Janssen.

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“…Ileocolonoscopy currently represents the gold standard for assessing CD recurrence, graded according to the Rutgeerts' score. Several alternative, noninvasive techniques have been used in order to assess the post-operative recurrence, including: fecal alpha 1-antitrypsin clearance, fecal calprotectin, 99 Tc-HM-PAO scintigraphy, virtual colonoscopy, ultrasonography, and SBVCE (24)(25)(26). CD patients previously submitted to intestinal surgery were found to have less PC detection/ retention (OR 0.16, p = 0.006).…”

Section: Discussionmentioning

confidence: 99%

Predictive factors of small bowel patency in Crohn's disease patients

Albuquerque¹,

Cardoso²,

Marques³

et al. 2015

Rev Esp Enferm Dig

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Non-invasive techniques for assessing postoperative recurrence in Crohn's disease

Cited by 44 publications

References 40 publications

Clinical Studies Evaluating Effects of Probiotics on Parameters of Intestinal Barrier Function

Clinical Studies Evaluating Effects of Probiotics on Parameters of Intestinal Barrier Function

Measurement of Fecal Calprotectin Improves Monitoring and Detection of Recurrence of Crohn's Disease After Surgery

Predictive factors of small bowel patency in Crohn's disease patients

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