Non-invasive transdermal delivery of biomacromolecules with fluorocarbon-modified chitosan for melanoma immunotherapy and viral vaccines

Zhu, Wenjun; Wei, Ting; Xu, Yuchun; Jin, Qiutong; Chao, Yu; Lu, Jiaqi; Xu, Jun; Zhu, Jiafei; Yan, Xiaoying; Chen, Muchao; Chen, Qian; Liu, Zhuang

doi:10.1038/s41467-024-45158-6

Cited by 18 publications

(2 citation statements)

References 57 publications

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“…The goal of needle-free transdermal application of biomacromolecules was likewise targeted by Zhu et al [ 191 ], who developed a transdermal delivery platform based on biocompatible fluorocarbon modified chitosan, proposed for antibody and antigen delivery. Mouse models were used to test the penetration potential and induced immune responses, suggesting promising results.…”

Section: Outlook—current Approaches and Research Trendsmentioning

confidence: 99%

Progress in Topical and Transdermal Drug Delivery Research—Focus on Nanoformulations

Lunter,

Klang,

Eichner

et al. 2024

Pharmaceutics

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Skin is the largest organ and a multifunctional interface between the body and its environment. It acts as a barrier against cold, heat, injuries, infections, chemicals, radiations or other exogeneous factors, and it is also known as the mirror of the soul. The skin is involved in body temperature regulation by the storage of fat and water. It is an interesting tissue in regard to the local and transdermal application of active ingredients for prevention or treatment of pathological conditions. Topical and transdermal delivery is an emerging route of drug and cosmetic administration. It is beneficial for avoiding side effects and rapid metabolism. Many pharmaceutical, technological and cosmetic innovations have been described and patented recently in the field. In this review, the main features of skin morphology and physiology are presented and are being followed by the description of classical and novel nanoparticulate dermal and transdermal drug formulations. The biophysical aspects of the penetration of drugs and cosmetics into or across the dermal barrier and their investigation in diffusion chambers, skin-on-a-chip devices, high-throughput measuring systems or with advanced analytical techniques are also shown. The current knowledge about mathematical modeling of skin penetration and the future perspectives are briefly discussed in the end, all also involving nanoparticulated systems.

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Section: Outlook—current Approaches and Research Trendsmentioning

confidence: 99%

Progress in Topical and Transdermal Drug Delivery Research—Focus on Nanoformulations

Lunter,

Klang,

Eichner

et al. 2024

Pharmaceutics

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show abstract

“…Therefore, improving the route of administration is a major concern in ongoing vaccine research. Transdermal and oral delivery of vaccines are considered to be the best alternatives to injections because of the ease of administration and better bioavailability of these routes [5]. The presence of keratinocytes, Langerhans cells, dendritic cells, and mast cells makes the skin an immunocompetent and effective site for vaccination [4,6,7].…”

Section: Introductionmentioning

confidence: 99%

Ionic Liquid-Based Immunization Patch for the Transdermal Delivery of Antigens

Islam,

Nabila,

Wakabayashi

et al. 2024

Molecules

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Herein, we report a transdermal patch prepared using an ionic liquid-based solid in oil (IL-S/O) nanodispersion and a pressure-sensitive adhesive (PSA) to deliver the macromolecular antigenic protein, ovalbumin (OVA). The IL-S/O nanodispersion and a PSA were first mixed at an equal weight ratio, then coated onto a release liner, and covered with a support film. To evaluate the effect of the PSA, three types of PSAs, DURO-TAK 87-4098, DURO-TAK 87-4287, and DURO-TAK 87-235A, were used to obtain the corresponding IL-S/O patches SP-4098, SP-4287, and SP-235A, respectively. The prepared IL-S/O patches were characterized for surface morphology, viscoelasticity, and moisture content. In vitro skin penetration and in vivo immunization studies of the IL-S/O patches were performed using Yucatan micropig skin and the C57BL/6NJc1 mice model, respectively. The SP-4098 and SP-4287 delivered 5.49-fold and 5.47-fold higher amounts of drug compared with the aqueous formulation. Although both patches delivered a similar amount of drug, SP-4287 was not detached fully from the release liner after 30 days, indicating low stability. Mice immunized with the OVA-containing SP-4098 produced a 10-fold increase in anti-OVA IgG compared with those treated with an aqueous formulation. These findings suggested that the IL-S/O patch may be a good platform for the transdermal delivery of antigen molecules.

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Modified Chitosan for Highly Efficient Non‐Invasive Transdermal Delivery of Catalase to Repair and Prevent Skin Photodamages

Yan,

Xu,

Wei

et al. 2024

Adv Funct Materials

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Oxidative stress induced by excess reactive oxygen species (ROS) plays a significant role in the onset and progression of numerous skin disorders, necessitating effective antioxidant defenses to prevent and repair oxidative damage. However, existing systemic antioxidant therapies for skin diseases often fall short in efficiently delivering antioxidants to the diseased lesions. In this study, a novel non‐invasive transdermal delivery platform utilizing chitosan grafted with salcaprozate sodium (SCS) is designed for highly efficient delivery of biomolecular enzymes, such as catalase (CAT). After self‐assembling with catalase, the obtained SCS‐CAT nanocomplexes if topically applied in a cream demonstrate highly efficient skin penetration and accumulation. Owing to the ability of CAT to effectively scavenge ROS, topically applied SCS‐CAT nanocomplexes enable remarkable repair and protection effects against ultraviolet radiation B (UVB)‐induced skin photodamages by inhibiting cell apoptosis and inflammation. Moreover, such SCS‐CAT delivery platform holds promise for long‐term skin care applications due to its great biocompatibility. This research presents a simple yet transformative platform for the intradermal delivery of biological enzymes, presenting a promising avenue for treating various inflammatory skin disorders.

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Non-invasive transdermal delivery of biomacromolecules with fluorocarbon-modified chitosan for melanoma immunotherapy and viral vaccines

Cited by 18 publications

References 57 publications

Progress in Topical and Transdermal Drug Delivery Research—Focus on Nanoformulations

Progress in Topical and Transdermal Drug Delivery Research—Focus on Nanoformulations

Ionic Liquid-Based Immunization Patch for the Transdermal Delivery of Antigens

Modified Chitosan for Highly Efficient Non‐Invasive Transdermal Delivery of Catalase to Repair and Prevent Skin Photodamages

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