Non-invasive transient elastography for the prediction of liver toxicity following hematopoietic SCT

Auberger, Jutta; Graziadei, Ivo; Clausen, Johannes; Vogel, Wolfgang; Nachbaur, David

doi:10.1038/bmt.2012.113

Cited by 26 publications

(22 citation statements)

References 7 publications

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“…As shown by the results of our multivariable analysis, the liver SWV was positively correlated with the histologic score. These findings indicate the potential role of VTIQ for the diagnosis, assessment, and longitudinal follow‐up of HSOS, which align with the findings of previous research on other elastographic techniques, such as transient elastography, SWE, and acoustic radiation force impulse elastography …”

Section: Discussionsupporting

confidence: 88%

Role of Virtual Touch Tissue Imaging Quantification in the Assessment of Hepatic Sinusoidal Obstruction Syndrome in a Rat Model

Hao

Yang

et al. 2018

J of Ultrasound Medicine

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Objectives To investigate the value of liver stiffness in rats with various degrees of hepatic sinusoidal obstruction syndrome (HSOS) induced by monocrotaline by comparing liver histopathologic findings. Methods Seventy rats were randomly divided into a control group (n = 10), a low‐dose monocrotaline group (n = 30), and a high‐dose monocrotaline group (n = 30). After successful modeling, the liver shear wave velocity (SWV) by Virtual Touch tissue imaging quantification (Siemens Medical Solutions, Mountain View, CA) and the alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin levels of the groups were obtained on days 3 and 5, and the intergroup differences were compared. Liver histopathologic characteristics were analyzed to evaluate the degrees of HSOS, and the scores were recorded. Results On days 3 and 5, the total bilirubin, AST, and ALT, levels and liver SWV in the low‐ and high‐dose groups were elevated; the portal vein velocity (PVV) of these groups was decreased compared with the control group; and the high‐dose rats showed higher serum AST and ALT levels than the low‐dose rats. The high‐dose rats had a lower PVV than the low‐dose rats at day 3. The liver SWV values had significant correlations with the histologic score and PVV. In a multivariate analysis, the liver SWV (β = 0.813; P < .001) was independently associated with the histopathologic score. Conclusions Liver stiffness as measured by Virtual Touch tissue imaging quantification increases with the severity of HSOS and can be recommended as a marker for diagnosis and assessment of HSOS.

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Section: Discussionsupporting

confidence: 88%

Role of Virtual Touch Tissue Imaging Quantification in the Assessment of Hepatic Sinusoidal Obstruction Syndrome in a Rat Model

Hao

Yang

et al. 2018

J of Ultrasound Medicine

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“…In this analysis, 18% of cases showed baseline TE values >7.71 kPa suggestive for fibrosis. 11,24 In contrast to these findings, the prevalence of elevated LSM in our cohort was much lower and only two patients had TE results above the cutoff for advanced liver fibrosis. Consequently, both r-ARFI and TE at baseline did not exhibit any value with respect to prediction of complication after SCT.…”

Section: Discussioncontrasting

confidence: 51%

“…7,23 Recently, the potential clinical value of liver elastography for risk stratification in patients with hematological disorders has been demonstrated by Auberger et al, 11 who described an increased rate of liver toxicity following hematopoietic SCT in patients with elevated pretransplant liver stiffness. In this analysis, 18% of cases showed baseline TE values >7.71 kPa suggestive for fibrosis.…”

Section: Discussionmentioning

confidence: 99%

“…[8][9][10] In this line, preliminary data indicate a correlation of liver stiffness and liver toxicity following hematopoietic SCT. 11 We performed a prospective study to characterize the diagnostic value of B-mode, Doppler liver ultrasound and LSM for prediction and diagnosis of severe complications with and without liver involvement in SCT patients.…”

Section: Introductionmentioning

confidence: 99%

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Value of liver elastography and abdominal ultrasound for detection of complications of allogeneic hemopoietic SCT

Karlas

Weber

Nehring

et al. 2014

Bone Marrow Transplant

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Hepatic complications contribute to morbidity and mortality after allogeneic hemopoietic SCT. Liver Doppler ultrasound and elastography represent promising methods for pretransplant risk assessment and early detection of complications. Ultrasound (liver and spleen size, liver perfusion) and elastography (transient elastography (TE); right liver lobe acoustic radiation force impulse imaging (r-ARFI); left liver lobe ARFI (l-ARFI)) were prospectively evaluated in patients with indications for allo-SCT. Measurements were performed before and repeatedly after SCT. Results were compared with the incidence of life-threatening complications and death during the first 150 days after SCT. Of 59 included patients, 16 suffered from major complications and 9 of them died within the follow-up period. At baseline, liver and spleen size, liver perfusion, TE and r-ARFI did not differ significantly between patients with and without severe complications. In contrast, l-ARFI was significantly elevated in patients who later developed severe complications (1.58 ± 0.30 m/s vs 1.37 ± 0.27 m/s, P = 0.030). After SCT, l-ARFI values remained elevated and TE showed increasing liver stiffness in patients with complications. The value of conventional liver ultrasound for prediction of severe SCT complications is limited. Increased values for TE and l-ARFI are associated with severe SCT complications and demand further evaluation.

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“…The presence of cirrhosis was only identified during autopsy. This is in accord with the emerging concept that liver disease staging requires multidimensional assessment by noninvasive and invasive tests (Auberger et al 2012). The progressive natural course advocates careful evaluation including transient elastography, liver biopsy, or assessment of hepatic venous pressure gradient.…”

Section: Introductionmentioning

confidence: 76%

MNGIE Syndrome: Liver Cirrhosis Should Be Ruled Out Prior to Bone Marrow Transplantation

et al. 2012

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Mitochondrial neurogastrointestinal encephalopathy (MNGIE) is an autosomal recessive mitochondriopathy caused by loss-of-function mutations in the thymidine phosphorylase gene. The disease leads to premature death and is characterized by gastrointestinal dysmotility and cachexia, external ophthalmoplegia, a sensorimotor neuropathy, and leukoencephalopathy. Bone marrow transplantation (BMT) is the only potentially curative treatment that can achieve a sustained biochemical correction of the metabolic imbalances.

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Non-invasive transient elastography for the prediction of liver toxicity following hematopoietic SCT

Cited by 26 publications

References 7 publications

Role of Virtual Touch Tissue Imaging Quantification in the Assessment of Hepatic Sinusoidal Obstruction Syndrome in a Rat Model

Role of Virtual Touch Tissue Imaging Quantification in the Assessment of Hepatic Sinusoidal Obstruction Syndrome in a Rat Model

Value of liver elastography and abdominal ultrasound for detection of complications of allogeneic hemopoietic SCT

MNGIE Syndrome: Liver Cirrhosis Should Be Ruled Out Prior to Bone Marrow Transplantation

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