Non‐invasive ventilation of patients with acute asthma

Sheikh, Muhammad Adil; Tiruvoipati, Ravindranath; Hurley, James C.

doi:10.1111/imj.14208

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…The potential benefits of NPPV for children with acute asthma may be multifactorial. As mentioned previously, using NPPV earlier in high-risk children with acute severe asthma could reduce their work of breathing, and more time could be given for the pharmacological treatment to reach maximum effect (34). This could be reflected by the acutely improved BGA parameters, reduced RR, and favorably changed symptomatic scores following NPPV in children with acute asthma in this meta-analysis.…”

Section: Discussionmentioning

confidence: 52%

Noninvasive positive-pressure ventilation for children with acute asthma: a meta-analysis of randomized controlled trials

Dai

Wang

et al. 2023

Front. Pediatr.

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BackgroundNoninvasive positive-pressure ventilation (NPPV) can be effective in children with acute asthma. However, clinical evidence remains limited. The objective of the meta-analysis was to systematically assess NPPV's effectiveness and safety in treating children with acute asthma.MethodsRelevant randomized controlled trials were obtained from electronic resources, including PubMed, Embase, Cochrane's Library, Wanfang, and CNKI databases. The influence of potential heterogeneity was taken into account before using a random-effect model to pool the results.ResultsA total of 10 RCTs involving 558 children with acute asthma were included in the meta-analysis. Compared to conventional treatment alone, additional use of NPPV significantly improved early blood gas parameters such as the oxygen saturation (mean difference [MD]: 4.28%, 95% confidence interval [CI]: 1.51 to 7.04, p = 0.002; I2 = 80%), partial pressure of oxygen (MD: 10.61 mmHg, 95% CI: 6.06 to 15.16, p < 0.001; I2 = 89%), and partial pressure of carbon dioxide (MD: −6.29 mmHg, 95% CI: −9.81 to −2.77, p < 0.001; I2 = 85%) in the arterial blood. Moreover, NPPV was also associated with early reduced respiratory rate (MD: −12.90, 95% CI: −22.21 to −3.60, p = 0.007; I2 = 71%), improved symptom score (SMD: −1.85, 95% CI: −3.65 to −0.07, p = 0.04; I2 = 92%), and shortened hospital stay (MD: −1.82 days, 95% CI: −2.32 to −1.31, p < 0.001; I2 = 0%). No severe adverse events related to NPPV were reported.ConclusionsNPPV in children with acute asthma is associated with improved gas exchange, decreased respiratory rates, a lower symptom score, and a shorter hospital stay. These results suggest that NPPV may be as effective and safe as conventional treatment for pediatric patients with acute asthma.

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Section: Discussionmentioning

confidence: 52%

Noninvasive positive-pressure ventilation for children with acute asthma: a meta-analysis of randomized controlled trials

Dai

Wang

et al. 2023

Front. Pediatr.

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Characteristics of Patients with Asthma Attack Followed in the Intensive Care Unit

Karaoğlanoğlu

Bostan

ÖCAL

et al. 2023

Middle Black Sea Journal of Health Science

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Abstract Background/aim: Asthma attack is a critical reason for morbidity and mortality if not treated effectively at the right time. Data about the efficiency of noninvasive and invasive mechanical ventilation (NIV, IMV) in respiratory failure due to asthma attacks are scant. The aim of this study was to investigate the relationship between asthma-related factors, medical and NIV/IMV treatments received in the Intensive Care Unit (ICU), and the mortality rates and length of hospital stay, in asthma attacks. Methods: The characteristics of patients with severe asthma treated in Hacettepe University Medical ICU for a ten-year period were analyzed from patient records retrospectively. The association between age, sex, comorbidities, asthma duration, treatment, adherence to the treatment, the effectiveness of NIV/IMV treatment if performed, and asthma attack severity, length of hospital stay, and mortality were investigated. Results: A total of 22 patients were included in this study. In addition to medical treatment, eight (36.6%) patients received NIV, five (22.7%) received invasive mechanical ventilation (IMV), and five (22.7%) patients had both. Four (18.1%) patients died in the ICU. There was no significant relationship between these parameters and length of hospital stay and mortality. The relationship between baseline PaCO2, pH, and HCO3 and the difference of PaCO2, pH, and HCO3¯ changes were significant, indicating the correct and effective use of NIV/IMV. Conclusion: NIV applications, which have been proven to be effective in hypercapnic respiratory failure, were also found to be effective in hypoxemic respiratory failure due to asthma attacks. The absence of a relationship between the investigated parameters and mortality revealed that the reasons for the mortality might be infections or comorbidities, not the respiratory tract.

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Non‐invasive ventilation of patients with acute asthma

Cited by 2 publications

References 12 publications

Noninvasive positive-pressure ventilation for children with acute asthma: a meta-analysis of randomized controlled trials

Noninvasive positive-pressure ventilation for children with acute asthma: a meta-analysis of randomized controlled trials

Characteristics of Patients with Asthma Attack Followed in the Intensive Care Unit

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