Non-ionic CT contrast solutions rapidly alter bovine cartilage and meniscus mechanics

Baylon, Eva Gabriela; Crowder, Hollis A; Gold, Garry E.; Levenston, Marc E.

doi:10.1016/j.joca.2020.05.013

Cited by 5 publications

(2 citation statements)

References 34 publications

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“…This effect is exaggerated at 3 T because the peak signal-to-noise ratios for iodinated contrast dilutions are slightly lower than at 1.5 T [ 36 , 37 , 41 ]. Intra-articular administration of iodinated-based contrast agents is FDA-approved and considered safe, but in vitro studies have suggested chondrotoxicity [ 30 ] and transient increases in cartilage stiffness, which may result in an increased risk of tissue or cell damage during weightbearing [ 42 ].…”

Section: Technical Considerationsmentioning

confidence: 99%

SSR white paper: guidelines for utilization and performance of direct MR arthrography

Chang,

Bencardino,

French

et al. 2023

Skeletal Radiol

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Objective Direct magnetic resonance arthrography (dMRA) is often considered the most accurate imaging modality for the evaluation of intra-articular structures, but utilization and performance vary widely without consensus. The purpose of this white paper is to develop consensus recommendations on behalf of the Society of Skeletal Radiology (SSR) based on published literature and expert opinion. Materials and methods The Standards and Guidelines Committee of the SSR identified guidelines for utilization and performance of dMRA as an important topic for study and invited all SSR members with expertise and interest to volunteer for the white paper panel. This panel was tasked with determining an outline, reviewing the relevant literature, preparing a written document summarizing the issues and controversies, and providing recommendations. Results Twelve SSR members with expertise in dMRA formed the ad hoc white paper authorship committee. The published literature on dMRA was reviewed and summarized, focusing on clinical indications, technical considerations, safety, imaging protocols, complications, controversies, and gaps in knowledge. Recommendations for the utilization and performance of dMRA in the shoulder, elbow, wrist, hip, knee, and ankle/foot regions were developed in group consensus. Conclusion Although direct MR arthrography has been previously used for a wide variety of clinical indications, the authorship panel recommends more selective application of this minimally invasive procedure. At present, direct MR arthrography remains an important procedure in the armamentarium of the musculoskeletal radiologist and is especially valuable when conventional MRI is indeterminant or results are discrepant with clinical evaluation.

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Section: Technical Considerationsmentioning

confidence: 99%

SSR white paper: guidelines for utilization and performance of direct MR arthrography

Chang,

Bencardino,

French

et al. 2023

Skeletal Radiol

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“…Considering the inferior mechanical performance obtained with the hydrogel used in this study, our future directions will focus on improving the resistance but maintaining the optimum environment for proper cell proliferation and activity [24]. Another step forward will be to implant the newly developed structure on an animal model to also evaluate the in vivo evolution and joint function.…”

Section: Discussionmentioning

confidence: 99%

A 3D Bioprinted Human Meniscus Shape Enriched with Mesenchymal Cells

et al. 2021

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Background and objectives: Regenerative medicine, with its massive development over the years, has the potential to solve some of the most problematic medical issues, such as functional organ transplantation. The aim of this study was to create a human meniscal shape 3D-printed enriched with human adipose-derived mesenchymal cells. Materials and Methods: Human infrapatellar fat pad was harvested, and mesenchymal cells were isolated. The mesenchymal stem cells were differentiated to the chondrocite lineage and a hydrogel (a nanofibrillar cellulose, sodium alginate, D-mannitol, and Hepes buffer solution combination) cell mixture was bioprinted to create three human-size meniscus structures. The obtained structures were evaluated regarding the cell viability, appropriate size in relation to a native meniscus, and some mechanical characteristics. Results: The human meniscal shape created respected the anatomic characteristic of a native structure. Cell viability of approximately 97% and extracellular matrix formation after the printing process were observed. The mean maximum force for the meniscus with mesenchymal cells was 6.5 N (+/−0.5 N) compared to the mean maximum force for the native meniscus of 10.32 N (+/−0.7 N), which is statistically relevant (p < 0.01). Conclusion: This paper presents the potential of bioprinting viable cell structures that could in the future present enough mechanical strength to replace a human organ, such as a meniscus. There are still limitations regarding the ink and the printing process, but we are confident that these problems will soon be solvable.

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Photon-counting in dual-contrast-enhanced computed tomography: a proof-of-concept quantitative biomechanical assessment of articular cartilage

Paakkari,

Inkinen,

Mohammadi

et al. 2024

Sci Rep

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This proof-of-concept study explores quantitative imaging of articular cartilage using photon-counting detector computed tomography (PCD-CT) with a dual-contrast agent approach, comparing it to clinical dual-energy CT (DECT). The diffusion of cationic iodinated CA4 + and non-ionic gadolinium-based gadoteridol contrast agents into ex vivo bovine medial tibial plateau cartilage was tracked over 72 h. Continuous maps of the contrast agents’ diffusion were created, and correlations with biomechanical indentation parameters (equilibrium and instantaneous moduli, and relaxation time constants) were examined at 28 specific locations. Cartilage at each location was analyzed as full-thickness to ensure a fair comparison, and calibration-based material decomposition was employed for concentration estimation. Both DECT and PCD-CT exhibit strong correlations between CA4 + content and biomechanical parameters, with PCD-CT showing superior significance, especially at later time points. DECT lacks significant correlations with gadoteridol-related parameters, while PCD-CT identifies noteworthy correlations between gadoteridol diffusion and biomechanical parameters. In summary, the experimental PCD-CT setup demonstrates superior accuracy and sensitivity in concentration estimation, suggesting its potential as a more effective tool for quantitatively assessing articular cartilage condition compared to a conventional clinical DECT scanner.

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Non-ionic CT contrast solutions rapidly alter bovine cartilage and meniscus mechanics

Cited by 5 publications

References 34 publications

SSR white paper: guidelines for utilization and performance of direct MR arthrography

SSR white paper: guidelines for utilization and performance of direct MR arthrography

A 3D Bioprinted Human Meniscus Shape Enriched with Mesenchymal Cells

Photon-counting in dual-contrast-enhanced computed tomography: a proof-of-concept quantitative biomechanical assessment of articular cartilage

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