Non-ionic self-assembling amphiphilic polyester dendrimers as new drug delivery excipients

Abstract

Solubility enhancement of poorly soluble antibiotics via self-assembling nano systems could be a promising approach to effectively treat bacterial infections in the current scenario of evolving resistant species.

Synthesis of an oleic acid based pH-responsive lipid and its application in nanodelivery of vancomycin

“…NMEO displayed a cell viability between 79.42 to 88.12%, 78.42 to 81.75% and 76.96 to 79.70% for A549, HEK-293 and HEP G2 cells respectively (Figure 3.2). The results displayed no dose dependent trends and is consistent with previous studies that report on materials that exhibit cell viability that is independent of the concentration (Romic et al, 2016;Di Gioia et al, 2015;Sikwal et al, 2017).…”

Newer Non‐ionic A2B2‐Type Enzyme‐Responsive Amphiphiles for Drug Delivery

“…Considering various possible structures among gemini amphiphiles, the nonionic one is advantageous for the drug delivery applications due to reduced cytotoxicity. [43][44][45] Furthermore, the presence of two hydrophobic alkyl tails in gemini amphiphiles allow sharp and uniform decrease in CAC value than their monomeric counterparts and thus making a valuable contribution for therapeutic applications. Nonionic gemini amphiphiles based on carbohydrates are known in the literature.…”

Formulation and Molecular Dynamics Simulations of a Fusidic Acid Nanosuspension for Simultaneously Enhancing Solubility and Antibacterial Activity

“…Despite FA being an effective agent against Gram-positive bacteria, there has been only one report for enhancing its solubility and activity using nanomicelles, which further involved the use of a newly synthesized material, i.e., polyester dendrimers. 40 A nano precipitation antisolvent technique, which was used to formulate nanosuspensions, has been shown to have advantages, such as little energy input, readily available machinery, and easy scale-up. It also allows for the preparation of nanosuspensions without the use of additional specialized materials, like the study reported by Sikwal et al 40 Development of pharmaceutical dosage forms requires an understanding of the in vitro and in vivo performance of the dosage forms.…”

“…40 A nano precipitation antisolvent technique, which was used to formulate nanosuspensions, has been shown to have advantages, such as little energy input, readily available machinery, and easy scale-up. It also allows for the preparation of nanosuspensions without the use of additional specialized materials, like the study reported by Sikwal et al 40 Development of pharmaceutical dosage forms requires an understanding of the in vitro and in vivo performance of the dosage forms. In vitro studies have been shown to be convenient as they (a) reduce costs, (b) provide an opportunity to more directly assess product performance, and (c) offer benefits in terms of ethical considerations.…”

“…To the best of our knowledge, there are no reports on FA nanosuspension as a drug delivery system. Despite FA being an effective agent against Gram-positive bacteria, there has been only one report for enhancing its solubility and activity using nanomicelles, which further involved the use of a newly synthesized material, i.e., polyester dendrimers . A nano precipitation antisolvent technique, which was used to formulate nanosuspensions, has been shown to have advantages, such as little energy input, readily available machinery, and easy scale-up.…”