Non-ischemic cardiomyopathy with focal segmental glomerulosclerosis

Kaur, Parminder; Singh, Balraj; Patel, Prem; Vasudev, Rahul; Rampal, Upamanyu; Shamoon, Fayez

doi:10.1080/20009666.2020.1742470

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…In comparison to other glomerular disease diagnoses, the prevalence of FSGS appears to be on the rise internationally, and it is a leading cause of endstage renal disease (ESRD). Due to large global discrepancies in the indications, accessibility, and pathology support for kidney biopsy, it is difficult to determine the true incidence and prevalence of FSGS [7] .…”

Section: Discussionmentioning

confidence: 99%

The Role of Matrix Metalloproteinase Inhibitor (Doxycycline) for the Treatment of Primary Focal Segmental Glomerulosclerosis

2023

The Egyptian Journal of Hospital Medicine

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Background: Nephrotic range proteinuria, segmental obliteration or collapse of glomerular capillary loops in some glomeruli, and increased extracellular matrix are the hallmarks of the podocytopathy known as focal and segmental glomerulosclerosis (FSGS). Objective: This research set out to determine if the matrix metalloproteinase inhibitor doxycycline (DOX) could be useful in the management of primary focal segmental glomerulosclerosis. Patients and Methods: This prospective cohort study was conducted on 100 patients with primary FSGS, who were recruited from Nephrology Department at Benha University Hospital. Informed consents were signed after getting approval from the Ethics Committee of Benha University. Inclusion criteria were age >18 years, primary FSGS, diagnosis is confirmed by renal biopsy, patients with overt albuminuria (A/C ratio>30 mg/g and urinary albumin > 30 mg/day). Results: The hemoglobin level was significantly higher at follow-up compared to baseline level in group 1 (P=0.026) and was insignificantly different between baseline and at follow-up in group 2. Hemoglobin level at baseline and follow-up was insignificantly different between both groups. C-reactive protein was significantly lower at followup compared to baseline level in group 1 and 2 (P<0.001). C-reactive protein was significantly lower at follow-up in group 2 compared to group 1 (P<0.001) and was insignificantly different between both groups at baseline. Platelet count and white blood cells were insignificantly different between baseline and at follow-up in both groups. There was an insignificant difference between both groups regarding platelet count and white blood cells at baseline and at followup. Conclusions: Patients who received DOX alongside conventional therapy exhibited notable improvements in clinical and biochemical parameters, including reduced proteinuria and enhanced kidney function, compared to those receiving conventional therapy alone. These findings suggest that DOX may hold promise as a supplementary treatment strategy for FS.

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Section: Discussionmentioning

confidence: 99%

The Role of Matrix Metalloproteinase Inhibitor (Doxycycline) for the Treatment of Primary Focal Segmental Glomerulosclerosis

2023

The Egyptian Journal of Hospital Medicine

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Left ventricular global longitudinal strain can detect subclinical left ventricular systolic dysfunction in adult patients with primary nephrotic syndrome

Çap

Aydın

Kadiroglu

et al. 2023

Int J Cardiovasc Imaging

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A “non-muscle” α-actinin is an intrinsic component of the cardiac Z-disc and regulates sarcomere turnover, contractility, and heart remodeling

Hayes,

Ritter,

Neininger-Castro

et al. 2024

Preprint

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Cardiac sarcomeres generate the fundamental forces behind each heartbeat and are thought to contain only muscle-specific cytoskeletal proteins. We show that a widely expressed actin cross-linking protein, α-actinin 4 (ACTN4), is a sarcomere component of the human and zebrafish heartin vivoand in human iPSC-derived cardiac myocytes (CMs)in vitro. A confluence of biochemical experiments, immunofluorescence, and AI modeling suggest ACTN4 forms a heterodimeric complex with muscle-specific ACTN2 at the cardiac Z-disc, the cardiac sarcomere border. ACTN4 depletion from human iPSC-CMs stabilizes canonical sarcomere proteins and drives contractility-dependent cellular hypertrophy while ACTN4 overexpression destabilizes sarcomeres. ACTN4 depletion from zebrafish embryos specifically increases ventricular contractility which drives atrial enlargement, suggesting biomechanically driven atrial remodeling. ACTN4-associated phenotypes in both model systems lack hallmarks of cardiac disease models and an ACTN4 variant in humans is associated with reduced risk for disease. Our findings suggest a “non-muscle” actinin regulates heart contractility and influences clinical outcomes related to heart failure.

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Non-ischemic cardiomyopathy with focal segmental glomerulosclerosis

Cited by 3 publications

References 17 publications

The Role of Matrix Metalloproteinase Inhibitor (Doxycycline) for the Treatment of Primary Focal Segmental Glomerulosclerosis

The Role of Matrix Metalloproteinase Inhibitor (Doxycycline) for the Treatment of Primary Focal Segmental Glomerulosclerosis

Left ventricular global longitudinal strain can detect subclinical left ventricular systolic dysfunction in adult patients with primary nephrotic syndrome

A “non-muscle” α-actinin is an intrinsic component of the cardiac Z-disc and regulates sarcomere turnover, contractility, and heart remodeling

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