Non-Jewish Israeli IBD Patients Have Significantly Higher Glutathione S-Transferase GSTT1-Null Frequency

Karban, Amir; Krivoy, Norberto; Elkin, Hela; Adler, Lior; Chowers, Yehuda; Eliakim, Rami; Efrati, Edna

doi:10.1007/s10620-010-1543-4

Cited by 21 publications

(28 citation statements)

References 34 publications

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“…This family presents a strong genetic variability among human populations and its molecular diversity is determined by ethnic background [21]. The null polymorphic variants (homozygous for nonfunctional allele) GSTM1 and GSTT1 have been associated with a variety of health problems, such as high blood pressure in subjects from India and with the development of inflammatory bowel disease in non-Jewish patients from Israel [22, 23]. The allelic frequency of those genes showed considerable variation among Native Americans from Venezuela, where 15.2% of the Panare and 54.3% of Bari tribes presented GSTM1 null genotype whereas none of the Pemon/Warao and 11.4% of Bari tribes presented GSTT1 null genotype [24].…”

Section: Gst and Mercury Exposurementioning

confidence: 99%

Biomarkers of Mercury Exposure in the Amazon

Castro

Lima

2014

BioMed Research International

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Mercury exposure in the Amazon has been studied since the 1980s decade and the assessment of human mercury exposure in the Amazon is difficult given that the natural occurrence of this metal is high and the concentration of mercury in biological samples of this population exceeds the standardized value of normality established by WHO. Few studies have focused on the discovery of mercury biomarkers in the region's population. In this way, some studies have used genetics as well as immunological and cytogenetic tools in order to find a molecular biomarker for assessing the toxicological effect of mercury in the Amazonian population. Most of those studies focused attention on the relation between mercury exposure and autoimmunity and, because of that, they will be discussed in more detail. Here we introduce the general aspects involved with each biomarker that was studied in the region in order to contextualize the reader and add information about the Amazonian life style and health that may be considered for future studies. We hope that, in the future, the toxicological studies in this field use high technological tools, such as the next generation sequencing and proteomics skills, in order to comprehend basic questions regarding the metabolic route of mercury in populations that are under constant exposure, such as in the Amazon.

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Section: Gst and Mercury Exposurementioning

confidence: 99%

Biomarkers of Mercury Exposure in the Amazon

Castro

Lima

2014

BioMed Research International

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“…Duncan et al showed the GSTT1 null genotype increased UC susceptibility but was not associated with CD [17]. Conversely, Karban et al reported the GSTT1 null genotype increased susceptibility to CD but not UC [20]. Ernst et al reported the GSTT1 null genotype was not associated with UC or CD [19].…”

Section: Introductionmentioning

confidence: 99%

Glutathione S-Transferase T1 Null Genotype is Associated with Susceptibility to Inflammatory Bowel Disease

Qian¹,

Song

et al. 2017

Cell Physiol Biochem

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Background: The published literature contains conflicting results regarding the impact of the glutathione S-transferase T1 (GSTT1) null genotype on the susceptibility to inflammatory bowel disease. Therefore, we conducted a meta-analysis of observational studies to assess the association. Methods: We searched four online databases for eligible studies. The odds ratio (OR) with 95% CI was used to assess the gene-disease association. We also performed subgroup analyses by type of inflammatory bowel disease and ethnicity. Results: There were 16 individual studies from 11 publications included in the analysis. There were 3366 cases with inflammatory bowel disease and 6013 controls. The meta-analysis of all 16 studies showed the GSTT1 null genotype was associated with increased susceptibility to inflammatory bowel disease (OR = 1.98, 95%CI 1.39-2.84, P < 0.001). The subgroup analysis by ethnicity further identified an association between the GSTT1 null genotype and inflammatory bowel disease in Caucasians, Asians, and Africans. The GSTT1 null genotype was associated with both ulcerative colitis (OR = 1.96, P = 0.004) and Crohn’s disease (OR = 2.01, P = 0.022). The GSTT1 null genotype was still significantly associated with ulcerative colitis (OR = 1.63, P < 0.0001) and Crohn’s disease (OR = 1.40, P = 0.023) after adjusting for study heterogeneity. Conclusion: The GSTT1 null genotype is significantly associated with an increased susceptibility to inflammatory bowel disease and is a risk factor for both ulcerative colitis and Crohn’s disease.

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“…[917] As recently reviewed, the prevalence of GSTM1 null allele ranges from 22% in Africans to 62% among Europeans, whereas GSTT1 null status differs from 20% to 60% in Caucasian and Asian people, respectively. [2122] Due to the important role of GSTs in oxidative stress and detoxifying carcinogens, GSTM1 and GSTT1 allelic polymorphisms may result in less effective removal of intestinal toxic metabolites, thus modifying the susceptibility to UC and CD. [2142223]…”

Section: Introductionmentioning

confidence: 99%

“…[2122] Due to the important role of GSTs in oxidative stress and detoxifying carcinogens, GSTM1 and GSTT1 allelic polymorphisms may result in less effective removal of intestinal toxic metabolites, thus modifying the susceptibility to UC and CD. [2142223]…”

Section: Introductionmentioning

confidence: 99%

Association Study of Glutathione S-transferases Gene Polymorphisms (GSTM1 and GSTT1) with Ulcerative Colitis and Crohn's Disease in the South of Iran

Moini

Saadat

et al. 2017

Adv Biomed Res

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Background:Inflammatory bowel diseases (IBDs), including ulcerative colitis (UC) and Crohn's disease (CD), are chronic inflammatory disorders of the gastrointestinal tract. A combination of environmental factors and interactions with a genetic predisposition are suggested to play an important role in the etiology and pathogenesis of the IBD. Glutathione S-transferases (GSTs) are multifunctional enzymes involved in the cellular oxidative stress handling. Possible associations between GSTs gene polymorphisms and susceptibility to UC and CD have been reported in different population. The relationship between GSTM1 and GSTT1 deletion polymorphisms and susceptibility to UC and CD were investigated in the Iranian population.Materials and Methods:The study was performed in 106 IBD patients and 243 age- and sex-matched healthy Iranian controls consulting the IBD registry center of the Motahari Clinic, Shiraz University of Medical Sciences, Shiraz, Iran, between 2011 and 2013. GSTM1 and GSTT1 genotyping were performed using multiplex polymerase chain reaction and differences in the distribution of gene polymorphisms were analyzed statistically between the studied groups.Results:Statistically significant higher frequency of GSTM1 null genotype was observed in IBD patients (P = 0.01) and in the subgroup of patients with UC (P = 0.04) compared to healthy controls, whereas this was not true for CD patients. No significant association was found between GSTT1 gene polymorphism and UC or CD.Conclusions:Absence of GSTT1 functional gene does not play an important role in the pathophysiology and development of IBD, UC, and CD in Iranian population whereas GSTM1 null genotype could be considered as a possible genetic predisposing factor for more susceptibility to IBD and UC.

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Non-Jewish Israeli IBD Patients Have Significantly Higher Glutathione S-Transferase GSTT1-Null Frequency

Abstract: GSTT1-null appears to be associated with IBD, while GSTM1-null appears to be conversely associated with IBD. No association was found between GSTT1-null or GSTM1-null and specific IBD phenotypes.

Cited by 21 publications

References 34 publications

Biomarkers of Mercury Exposure in the Amazon

Biomarkers of Mercury Exposure in the Amazon

Glutathione S-Transferase T1 Null Genotype is Associated with Susceptibility to Inflammatory Bowel Disease

Association Study of Glutathione S-transferases Gene Polymorphisms (GSTM1 and GSTT1) with Ulcerative Colitis and Crohn's Disease in the South of Iran

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