Non-linear association between composite dietary antioxidant index and depression

Zhao, Leiyong; Sun, Yiyan; Cao, Renshuang; Huang, Tianjiao; Peng, Wei

doi:10.3389/fpubh.2022.988727

Cited by 48 publications

(21 citation statements)

References 39 publications

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“…The CDAI comprises vitamins (A, C, and E) and nutritional factors (zinc and selenium), as a score of total dietary antioxidants, and is widely used in the clinical situations. High CDAI is a protective factor against depression, 11 and higher CDAI has been linked to decreased cardiovascular mortality risk 10 . Vitamin C supplementation increased myocardial contractility and endothelial function 19 .…”

Section: Discussionmentioning

confidence: 99%

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Composite dietary antioxidant index and the risk of heart failure: A cross‐sectional study from NHANES

Ma,

Liu,

Sun

et al. 2023

Clinical Cardiology

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BackgroundPrevious studies show that oxidative stress is important in heart failure (HF) pathogenesis. The composite dietary antioxidant index (CDAI), which reflects the antioxidant profile of nutrient supplements, is associated with cardiovascular mortality risk. However, the association between CDAI and the risk of HF remains unknown.HypothesisIn this study, we investigated the relationship between CDAI and HF risk using National Health and Nutritional Examination Survey (NHANES) data.MethodsThe data of participants aged >40 years old from the NHNANES between 2001 and 2018 were obtained and used to assess the relationship between CDAI and the risk of HF. Logistic regression was used to calculate the odds ratio (OR) of CDAI for the risk of HF.ResultsA total of 29 101 participants were divided into the HF (n = 1419; 4.88%) and non‐HF groups (n = 27 682; 95.12%), HF group participants had lower CDAI than the non‐HF group (−0.32 ± 0.14 vs. 0.67 ± 0.05, p < .0001). Compared with the lowest CDAI quartile (Q1), the OR for HF risk was 0.88 (0.68−1.13) for Q2 (p = .30), 0.77 (0.61−0.99) for Q3 (p = .04), and 0.68 (0.52−0.89) for Q4 (p = .01).ConclusionsCDAI was negatively associated with the risk of HF. Our findings show that the intake of an antioxidant‐rich dietary is a potential method to reduce the risk of HF.

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Section: Discussionmentioning

confidence: 99%

“…The survey was approved by the National Center for Health Statistics Ethical Review Board, and all participants provided informed consent. Researchers can access the database without applying 11 …”

Section: Methodsmentioning

confidence: 99%

Composite dietary antioxidant index and the risk of heart failure: A cross‐sectional study from NHANES

Ma,

Liu,

Sun

et al. 2023

Clinical Cardiology

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“…The composite dietary antioxidant index (CDAI) is a measurement of individual antioxidant profiles derived from dietary combinations developed to assess and reflect the overall impact of dietary antioxidants on health 19 . Initially, research on the CDAI predominantly addressed cancer; however, its relevance has increasingly expanded into psychiatry in recent years 20 , 21 . An Iranian study highlighted that the dietary antioxidant index was associated with a reduced incidence of depression and anxiety in young women.…”

Section: Introductionmentioning

confidence: 99%

Association of composite dietary antioxidant index with depression and all-cause mortality in middle-aged and elderly population

Luo,

Xu,

Sun

et al. 2024

Sci Rep

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Current research has shown an increasing acceptance of interventions for depression through dietary modifications. However, whether composite dietary antioxidant index (CDAI) is associated with depression and all-cause mortality in middle-aged and elderly population remains unknown. This study aimed to explore those associations in American middle-aged and elderly population. Weighted logistic regression models and weighted Cox proportional hazard regression models were used to assess the association of CDAI, covariates, depression, and all-cause mortality, respectively. The stability of the results was also determined by a linear trend test based on CDAI quintiles. Restricted cubic spline curves were employed to test for non-linear relationships. In the model adjusted for all covariates, significant associations were found with the ORs (95% CI) for CDAI and depression [0.77 (0.67, 0.89)] and the HRs (95% CI) for CDAI with all-cause mortality[0.91 (0.83, 1.00)]. Upon conducting restricted cubic spline curves, we found that the association between CDAI and depression was linear, whereas the association between CDAI and all-cause mortality was non-linear with an inflection point of -0.19. Statistical significance was only found before the inflection point. In this study of middle-aged and elderly Americans, CDAI was linearly negatively associated with depression and non-linearly negatively associated with all-cause mortality.

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“…The CDAI was developed based on its combined effect on anti-inflammatory effects based on the pro-inflammatory markers Tumor Necrosis Factor-α (TNF-α) and Interleukin-1β (IL-1β), which are associated with many health outcomes, including depression, all-cause mortality, colorectal cancer, etc. (21)(22)(23)(24)(25).…”

Section: Introductionmentioning

confidence: 99%

Association between composite dietary antioxidant index and handgrip strength in American adults: Data from National Health and Nutrition Examination Survey (NHANES, 2011-2014)

Wang

et al. 2023

Front. Nutr.

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BackgroundThe Composite Dietary Antioxidant Index (CDAI), a composite score of multiple dietary antioxidants (including vitamin A, C, and E, selenium, zinc, and carotenoids), represents an individual’s comprehensive dietary antioxidant intake profile. CDAI was developed based on its combined effect on pro-inflammatory markers Tumor Necrosis Factor-α (TNF-α) and anti-inflammatory effects of Interleukin-1β (IL-1β), which are associated with many health outcomes, including depression, all-cause mortality, colorectal cancer, etc. Handgrip strength is used as a simple measure of muscle strength, not only is it highly correlated with overall muscle strength, but also serves as a diagnostic tool for many adverse health outcomes, including sarcopenia and frailty syndromes.PurposeThe association between CDAI and Handgrip strength (HGS) is currently unclear. This study investigated the association between CDAI (including its components) and HGS in 6,019 American adults.MethodThe research data were selected from the 2011–2014 National Health and Nutrition Survey (NHANES), and a total of 6,019 American adults were screened and included. A weighted generalized linear regression model was used to evaluate CDAI (including its components) and HGS.Results(1) CDAI was significantly positively correlated with HGS (β = 0.009, 0.005∼0.013, P < 0.001), and the trend test showed that compared with the lowest quartile of CDAI, the highest quartile of CDAI was positively correlated with HGS (β = 0.084, 0.042∼0.126, P = 0.002) and significant in trend test (P for trend < 0.0100). Gender subgroup analysis showed that male CDAI was significantly positively correlated with HGS (β = 0.015, 0.007∼0.023, P = 0.002), and the trend test showed that compared with the lowest quartile of CDAI, the highest quartile of CDAI was positively correlated with HGS (β = 0.131, 0.049∼0.213, P = 0.006) and the trend test was significant (P for trend < 0.0100). There was no correlation between female CDAI and HGS, and the trend test was not statistically significant (P > 0.05). (2) The intake of dietary vitamin E, Zinc and Selenium showed a significant positive correlation with HGS (β = 0.004, 0.002∼0.007, P = 0.006; β = 0.007, 0.004∼0.009, P < 0.001; β = 0.001, 0.001∼0.001, P < 0.001), vitamin A, vitamin C and carotenoid were significantly associated with HGS in the Crude Model, but this significant association disappeared in the complete model with the increase of control variables. Gender subgroup analysis showed that in model 3, male dietary intake levels of vitamin E, Zinc, and Selenium were significantly positively correlated with HGS (β = 0.005, 0.002∼0.009, P = 0.011; β = 0.007, 0.004∼0.011, P = 0.001; β = 0.001, 0.001∼0.001, P = 0.004), the rest of the indicators had no significant correlation with HGS. Among the female subjects, dietary zinc intake was significantly positively correlated with HGS (β = 0.005, 0.001∼0.008, P = 0.008), and there was no significant correlation between other indicators and HGS (P > 0.05).ConclusionThere was an association between the CDAI and HGS, but there was a gender difference, and there was an association between the CDAI and HGS in male, but the association was not significant in female. Intake of the dietary antioxidants vitamin E, selenium, and zinc was associated with HGS in male, but only zinc was associated with HGS among dietary antioxidants in female.

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Non-linear association between composite dietary antioxidant index and depression

Cited by 48 publications

References 39 publications

Composite dietary antioxidant index and the risk of heart failure: A cross‐sectional study from NHANES

Composite dietary antioxidant index and the risk of heart failure: A cross‐sectional study from NHANES

Association of composite dietary antioxidant index with depression and all-cause mortality in middle-aged and elderly population

Association between composite dietary antioxidant index and handgrip strength in American adults: Data from National Health and Nutrition Examination Survey (NHANES, 2011-2014)

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