Non-linear dynamic simulation of mechanical periodicity of end-diastolic volume of left ventricle under the influence of baroreflex

Abstract

Mechanical periodicity (MP) of the end-diastolic volume (EDV) of the left ventricle (LV) is closely associated with cardiovascular pathophysiology. On the basis of the Starling's law of the LV and Burattini and Gnudi's four-element model of the vascular system, and considering baroreceptor reflex, a non-linear dynamic lumped-parameter model is proposed. This simulates the MP phenomena of the EDV by solving a series of one-dimensional discrete non-linear dynamic equations. The results demonstrate that excessive deviations of some physiological parameters often induce MP -the unstable phenomena of EDV -and verify that the effects of baroreceptor reflex enhance the ability of the human physiological system to maintain stability.