This paper designs an observer‐based feedback controller for quasi‐linear systems when the entire state vector is unavailable for measurement. First, based on the solution of a type of generalised Sylvester equations, general complete parameterisation of the full‐order observer is proposed. Second, the traditional separation principle is applied to the quasi‐linear systems. In other words, the design of a state feedback and the design of a state observer can be carried out independently. Further, general complete parameterisation of the state feedback controller is also established. Finally, numerical examples and simulations are adopted to verify the effectiveness of the proposed method.