Non-linear Relationship of Maternal Age With Risk of Spontaneous Abortion: A Case-Control Study in the China Birth Cohort

Zhang, Man; Yang, Bo‐Yi; Sun, Yu; Qian, Zhengmin; Xaverius, Pamela K.; Aaron, Hannah E.; Zhao, Xiaoting; Zhang, Zheng; Liu, Ruixia; Dong, Guang‐Hui; Yin, Chenghong; Yue, Wentao

doi:10.3389/fpubh.2022.933654

Cited by 13 publications

(11 citation statements)

References 62 publications

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“…In addition, the probability of spontaneous abortion in women without corrected VD deficiency is 15.38%, while it is 46.88% in RSA women. These results indicate a certain relationship between VD deficiency and spontaneous abortion, which is consistent with the research conclusion of one study 13 . However, the specific pathogenesis of VD deficiency leading to spontaneous abortion is not yet clear, and possible factors include the following: Compared to women without spontaneous abortion and patients with one spontaneous abortion, RSA patients are older, with a mean age of 32.13 years.…”

Section: Discussionsupporting

confidence: 87%

“…These results indicate a certain relationship between VD deficiency and spontaneous abortion, which is consistent with the research conclusion of one study. 13 However, the specific pathogenesis of VD deficiency leading to spontaneous abortion is not yet clear, and possible factors include the following:…”

Section: Discussionmentioning

confidence: 99%

“…This is consistent with the view that age is an independent high‐risk factor for spontaneous abortion and RSA. In recent years, most studies 13‐15 have found that the risk of spontaneous abortion in women over 30 years old is significantly increased in a J‐shaped pattern, with a stronger association in the ages of 32 and above. Moreover, the rate of VD deficiency in RSA patients is 76.50%, and the rate is relatively high with increasing age, 16 which may be related to changes in female hormone levels caused by age, leading to a decrease in the capacity of VD absorption. When BMI is < 20 or > 24 kg/m 2 , patients are more likely to be in VD‐deficient or VD‐insufficient states, especially in the deficient states, which are more likely to cause spontaneous abortion.…”

Section: Discussionmentioning

confidence: 99%

“…The proportion of live births increased to 72.68%, and the clinical pregnancies and prepared pregnancies reached 13…”

Section: Pregnancy Outcomes Before and After Treatmentmentioning

confidence: 98%

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Study on the clinical value of Vitamin D in recurrent spontaneous abortion

Du,

Ye,

Lin

et al. 2024

American J Rep Immunol

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ObjectiveThis study explores the possible pathogenesis of recurrent spontaneous abortion (RSA) caused by vitamin D (VD), provides evidence‐based bases for prevention and treatment of RSA, improves female reproductive health.MethodsThis study randomly selected 305 patients without spontaneous abortion (SA0), 216 patients with a spontaneous abortion (SA1) and 200 patients with RSA from 1421 women of childbearing age who visited the RSA specialty clinic of Hangzhou First People's Hospital from January 2021 to June 2023 to conduct a prospective clinical study. Then, we collected the data of clinical diagnosis and treatment, conducted intervention and follow‐up, and finally executed statistical analysis.Results(1) RSA patients were significantly older than the other two groups. (2) The rates of VD deficiency in SA1 and RSA patients were significantly higher than those in SA0. (3) When BMI < 20 or > 24 kg/m2, there were abnormal increase in VD and increased number of spontaneous abortions. (4) The bilateral S/D of the VD‐sufficient, VD‐insufficient and VD‐deficient groups gradually increased with statistical significance (p ≤ .018). (5) Among the 65 cases undergoing embryo chromosome examinations, chromosomal abnormalities accounted for 55.38% and 69.05% in RSA patients. (6) Among 186 patients with abnormal ACA, there was a certain negative correlation between ACA and VD, which was stronger among RSA patients. Moreover, ACA significantly decreased (p < .001) after effectively supplementing VD, and the miscarriage rate of re‐pregnancy also decreased.ConclusionThe rate of VD deficiency is higher in RSA patients. VD deficiency may be related to the age of women of childbearing age and too low or high BMI, and may cause abnormal plasma antiphospholipid antibodies, increased uterine artery resistance and abnormal chromosomal division during fertilization, leading to spontaneous abortion and even RSA. The improvement of VD deficiency may reduce the risk of RSA occurrence.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The proportion of live births increased to 72.68%, and the clinical pregnancies and prepared pregnancies reached 13…”

Section: Pregnancy Outcomes Before and After Treatmentmentioning

confidence: 98%

See 2 more Smart Citations

Study on the clinical value of Vitamin D in recurrent spontaneous abortion

Du,

Ye,

Lin

et al. 2024

American J Rep Immunol

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“…25 In ensuing pregnancies, individuals with higher preconception and greater arteriolar and venular curvature tortuosity encountered a 25-34% increased risk of spontaneous abortion before 20 weeks' gestation. 26 The underlying pathophysiology, characterized by vascular inflammation, 27,28 hypoxia, 15,16 oxidative stress, 29 endothelial dysfunction, [30][31][32] and impaired uterine perfusion, 33,34 contributes to both reduced fecundability and spontaneous abortion, in addition to common risk factors like advanced maternal age, 35,36 stress, 37 cigarette smoking, 38 medication or substance use, 39,40 medical conditions, [41][42][43] and environmental pollution. 44 Women's antenatal health…”

Section: Women's Fertilitymentioning

confidence: 99%

Retinal Vascular Imaging Application in Women’s Reproductive Health: Clinical Implications and Future Directions

Lim,

2024

Maternal Fetal Med

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Over the past two decades, population-based studies employing semiautomatic computer-assisted programs have uncovered associations between retinal microvascular features and various systemic conditions. As the recognition of retinal imaging in cardiometabolic health grows, there is increasing evidence supporting its application in women’s health, particularly during the reproductive age. This review aims to summarize the indications of retinal imaging in women’s health and intergenerational health, where suboptimal retinal imaging has been found to mirror pathological systemic changes, such as suboptimal hemodynamic circulation, inflammation, endothelial dysfunction, oxidative stress, and hypoxia in vivo. Findings from Singapore Growing Up in Singapore Towards Healthy Outcomes and Singapore Preconception Study of Long-Term Maternal and Child Outcomes cohorts have reported serial changes in retinal conventional microvascular features (e.g., retinal arteriolar narrowing, retinal venular widening) and retinal geometric microvascular features (e.g., sparse fractal dimension, enlarged branching angle, and increased curvature tortuosity) during the preconception and antenatal phases. These morphological abnormalities were found to be related to female fertility, maternal antenatal health conditions, postnatal maternal cardiometabolic health, and intergenerational health in the fetus. Given the compelling evidence of the ability to detect microvascular changes through noninvasive methods at an early stage, retinal imaging holds the potential to facilitate timely interventions, mitigate the progression of complications, and prevent adverse pregnancy outcomes. Looking ahead, the convergence of artificial intelligence and advanced imaging techniques heralds a promising era in women’s health research and clinical practice.

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Maternal age and adverse pregnancy outcomes among Meitei women of Manipur, Northeast India: A cross‐sectional study

Devi,

Singh

2023

American J Hum Biol

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ObjectiveThe study examines the outcomes of pregnancies conceived at advanced maternal age (AMA) and maternal complications after childbirth among Meitei women of Northeast India.MethodA total of 760 women participants were included in this study and compared among women aged ≥35 years, with a reference group of women aged 20–34 years. Data on obstetric characteristics were collected after obtaining consent. The data were compared using chi‐square analysis, and the results were adjusted using a logistic regression model. Decision trees were developed to predict the potential variables associated with preterm delivery and postpartum complication.ResultsIn the study, 18.95% of AMA women experienced one or more adverse pregnancy outcomes (APOs). Women with AMA are at significantly increased risk of placenta previa (adjusted odds ratio [AOR] = 4.89, 95% confidence interval [CI]: 2.78–8.57), induction of labor (AOR = 3.69, 95%CI: 2.48–5.50), and caesarean section (AOR = 3.42, 95%CI: 2.28–5.12). Moreover, AMA women have a 1.86–2.76 AOR for developing gestational diabetes, pregnancy‐induced hypertension, urinary tract infections, preterm delivery, and postpartum complications. Decision tree analysis revealed that AMA and urban residence independently predict preterm delivery and postpartum complications.ConclusionThe study's findings confirm the adverse impact of AMA on pregnancy outcomes and postpartum complications. Such issues should be addressed, and counseling on the risk of AMA should be provided, particularly for those in the high‐risk group. Further prospective studies are needed to understand other potential risk factors of APOs and the impact of AMA complications to prevent the associated burden.

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Non-linear Relationship of Maternal Age With Risk of Spontaneous Abortion: A Case-Control Study in the China Birth Cohort

Cited by 13 publications

References 62 publications

Study on the clinical value of Vitamin D in recurrent spontaneous abortion

Study on the clinical value of Vitamin D in recurrent spontaneous abortion

Retinal Vascular Imaging Application in Women’s Reproductive Health: Clinical Implications and Future Directions

Maternal age and adverse pregnancy outcomes among Meitei women of Manipur, Northeast India: A cross‐sectional study

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