This paper deals with new elastoplastic models for crystalline materials with microstructural defects, such as dislocations and disclinations, which are consistent with the multislip plastic flow rule, and compatible with the free energy imbalance principle. The defect free energy function is a function of the disclination tensor and its gradient, and of the geometrically necessary dislocation (GND) tensor, via the Cartan torsion. By applying the free energy imbalance, the appropriate viscoplastic (diffusion-like) evolution equations are derived for shear plastic rates (in slip systems) and for the disclination tensor. The two sets of differential (or partial differential, i.e., non-local) equations describe the rate form of the adopted disclination–dislocation model. The first set is typical for finite deformation formalism, while the second set refers to the evolution equations with respect to the reference configuration. The dislocation appears to be a source for producing disclination defects. A pure dislocation elastoplastic model is also proposed. Multislip models with disclination within the small deformation approach are derived from the finite deformation models. The initial and boundary value problems are formulated and the incremental (rate) equilibrium equation leads to a variational equality for the velocity field, at any time, which is coupled with the rate type models for the set of variables. First, the elastic problem is solved for a certain time interval by assuming that the existing defects inside the body remain inactive. Subsequently, the variational equality is solved for the velocity field, at any time, if the slip systems are activated. Consequently, the state of the body with defects is defined by the solution of the differential-type equations, when the velocity field is known for a certain time interval. Appropriate initial conditions are necessary, including those associated with defects which became active. Finally, an update algorithm must be provided in order to compute the fields at the current moment.