Non-lupus full-house nephropathy: a case series

Silva, Márcia de Oliveira; Oliveira, Patrick Vanttinny Vieira de; Vale, Pedro Henrique Cavalcante; Cunha, Rinadja; Lages, Joyce Santos; Brito, Dyego José de Araújo; Filho, Natalino Salgado; Guedes, Felipe Leite; Silva, Gyl Eanes Barros; Santos, Ricardo Ferreira

doi:10.1590/2175-8239-jbn-2019-0242

Cited by 6 publications

(4 citation statements)

References 15 publications

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“…SLICC (The Systemic Lupus International Collaborating Clinics) used full-house staining as the sole criteria to diagnose SLE 3 . However, It has been reported that the prevalence of no-lupus full house nephropathy was 20%-30% [12][13][14][15] . "No-lupus full house nephropathy" is an umbrella term for such patients who may exhibit "lupus-like" nephropathy, but without presenting any extrarenal symptoms or serologies suggestive of SLE.…”

Section: Discussionmentioning

confidence: 99%

ANA negative with Severe Lupus-like presentation: Is it lupus or not?

Bian

2023

Preprint

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Section: Discussionmentioning

confidence: 99%

ANA negative with Severe Lupus-like presentation: Is it lupus or not?

Bian

2023

Preprint

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“… 3 However, it has been reported that the prevalence of no‐lupus full‐house nephropathy was 20%–30%. 12 , 13 , 14 , 15 Pathologies of full‐house nephropathy should also be considered in the differential diagnosis of SLE, including primary glomerular diseases (membranous nephropathy, C1q nephropathy, IgA nephropathy), infections (endocarditis, HIV, HBV, HCV, BK, and CMV virus), diabetes mellitus, and liver diseases. 12 , 13 , 14 This patient had none any evidence of these disease.…”

Section: Discussionmentioning

confidence: 99%

ANA‐negative severe lupus‐like presentation: Is it lupus or not?

Li,

Bian

2023

Clinical Case Reports

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Key Clinical MessageSystemic lupus erythematosus is difficult to diagnose in patients who are antinuclear antibody (ANA) negative and lack typical clinical manifestations. For such patient who presented ANA‐negative severe lupus‐like manifestations, the diagnosis and treatment are a huge challenge. Histological findings may provide clues to diagnosis.AbstractSystemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterized by formation of autoantibodies to nuclear and cytoplasmic antigens. It was reported that a small subset of patients had typical clinical features of SLE with consistently negative antinuclear antibody (ANA), but such disease is usually mild and rarely involves multisystem. At present, there are no reports about severe lupus with ANA continued negative. Our report describes a 34‐year‐old Chinese woman who presented renal failure, multiple serous cavity effusion, and epilepsy, without malar rash, photosensitivity, lymphopenia, and arthritis. Further renal biopsy pathology revealed lupus‐like nephritis. Autoantibodies, including ANA, antibodies against Smith and against double stranded DNA, were negative. Such a ANA negative and lack of typical clinical symptoms of SLE patient, but with severe lupus‐like manifestations, whether it was lupus or not is worth discussing.

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“…Non-lupus full house nephropathy is defined as having the classical findings of lupus nephritis which are positive deposits for IgG, IgA, IgM, C3, and C1q on immunofluorescence but without the other extrarenal or seologic manifestations needed for SLE diagnosis i.e ACR criteria. 1 Systemic lupus erythematosus is a multisystem autoimmune disorder. It can involve several organs with variable presentations.…”

Section: Introductionmentioning

confidence: 99%

A rare case of non‐lupus full house nephropathy in a transplanted kidney, case report

Matarneh,

Salameh,

Sardar

et al. 2024

Clinical Case Reports

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Key Clinical MessageNon‐lupus full house nephropathy is a rare entity that is still poorly understood. It can complicate post‐transplant kidneys and result in a de novo process. Treatment is difficult but can be possibly achieved with optimization of immune suppression.AbstractNon‐lupus full house nephropathy is a rare entity with an unclear incidence. It describes the kidney biopsy findings of positive deposits for IgG, IgA, IgM, C3, and C1q on immunofluorescence in the absence of the classical diagnostic features of systemic lupus nephritis. This disease entity is becoming more recognized but further studies are still needed to evaluate the incidence, etiologies, and management of this condition. Transplant glomerulopathy is a major cause for renal graft loss. It can present with a wide variety of manifestations; it can cause AKI, CKD, or glomerular inflammations through an immune complex or autoimmune‐mediated damage.

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Non-lupus full-house nephropathy: a case series

Cited by 6 publications

References 15 publications

ANA negative with Severe Lupus-like presentation: Is it lupus or not?

ANA negative with Severe Lupus-like presentation: Is it lupus or not?

ANA‐negative severe lupus‐like presentation: Is it lupus or not?

A rare case of non‐lupus full house nephropathy in a transplanted kidney, case report

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