Non‐MAO A binding of clorgyline in white matter in human brain

Fowler, Joanna S.; Logan, Jean; Ding, Yu; Franceschi, Dinko; Wang, G.-J.; Volkow, Nora D.; Pappas, Naomi; Schlyer, David; Gatley, S. John; Alexoff, David; Felder, Christoph; Biegon, Anat; Zhu, Wei

doi:10.1046/j.1471-4159.2001.00649.x

Cited by 31 publications

(19 citation statements)

References 26 publications

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“…PET time-activity data for [ 11 C]clorgyline from different brain regions and time-activity data in arterial plasma were used to calculate the model term K 1 , the plasma to brain transfer constant which is related to blood flow and λk 3 , which is a function of the concentration of catalytically active MAO A molecules (Fowler et al 2001). The model term k 3 is related to the binding of [ 11 C]clorgyline by MAO A; λis defined as K 1 /k 2 and is independent of blood flow and k 2 is related to the efflux of tracer from brain to blood.…”

Section: Discussionmentioning

confidence: 99%

“…Brain MAO A activity was measured in each subject with PET and [ 11 C]clorgyline (average dose 6.2 ± .7 mCi; specific activity 250 mCi/μmol) using the scanning protocol reported previously (Fowler et al 2001). Briefly, PET images were acquired using a whole body, highresolution PET (Siemen's HR+) in 3-dimensional dynamic acquisition mode.…”

Section: Methodsmentioning

confidence: 99%

“…The relationship between MAO A genotype and brain MAO A activity has never been examined in vivo in healthy human subjects, however. The purpose of this study was to determine whether high and low MAO A genotypes correspond to high and low brain MAO A activity in normal healthy male subjects using the MAO A radiotracer, [ 11 C]-clorgyline and positron emission tomography (PET; Fowler et al 1996aFowler et al , 2001). …”

Section: Brain Mao Activity; Mao a Genotypementioning

confidence: 99%

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Evidence That Brain MAO A Activity Does Not Correspond to MAO A Genotype in Healthy Male Subjects

Fowler

Alia‐Klein

Kriplani

et al. 2007

Biological Psychiatry

106

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Brain Mao Activity; Mao a Genotypementioning

confidence: 99%

See 1 more Smart Citation

Evidence That Brain MAO A Activity Does Not Correspond to MAO A Genotype in Healthy Male Subjects

Fowler

Alia‐Klein

Kriplani

et al. 2007

Biological Psychiatry

106

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show abstract

“…The K 1 is the plasma-to-brain transfer constant and is related to blood flow; k 2 is related to the transfer of tracer from brain to plasma. Finally, k 3 is an index of the amount of catalytically active MAO A (Fowler et al, 2001), where is defined as K 1 /k 2 and is independent of blood flow. It is important to note that the analyses herein are based on regions of interest (ROIs) that were manually drawn for each subject on an image formed by summing the time frames mentioned above.…”

Section: Methodsmentioning

confidence: 99%

Brain Monoamine Oxidase A Activity Predicts Trait Aggression

Alia‐Klein¹,

Goldstein²,

Kriplani³

et al. 2008

J. Neurosci.

Self Cite

224

137

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The genetic deletion of monoamine oxidase A (MAO A), an enzyme that breaks down the monoamine neurotransmitters norepinephrine, serotonin, and dopamine, produces aggressive phenotypes across species. Therefore, a common polymorphism in the MAO A gene (MAOA, Mendelian Inheritance in Men database number 309850, referred to as high or low based on transcription in non-neuronal cells) has been investigated in a number of externalizing behavioral and clinical phenotypes. These studies provide evidence linking the low MAOA genotype and violent behavior but only through interaction with severe environmental stressors during childhood. Here, we hypothesized that in healthy adult males the gene product of MAO A in the brain, rather than the gene per se, would be associated with regulating the concentration of brain amines involved in trait aggression. Brain MAO A activity was measured in vivo in healthy nonsmoking men with positron emission tomography using a radioligand specific for MAO A (clorgyline labeled with carbon 11). Trait aggression was measured with the multidimensional personality questionnaire (MPQ). Here we report for the first time that brain MAO A correlates inversely with the MPQ trait measure of aggression (but not with other personality traits) such that the lower the MAO A activity in cortical and subcortical brain regions, the higher the self-reported aggression (in both MAOA genotype groups) contributing to more than one-third of the variability. Because trait aggression is a measure used to predict antisocial behavior, these results underscore the relevance of MAO A as a neurochemical substrate of aberrant aggression.

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“…These activities may be shown in 0xotremorine antagonists [1,2,3], their effects on behavioral functional changes and central motor effects [4,5]. Aminoacetylenic compound showed Monoaminooxidase inhibitory activity type B as seen with Rasagiline (Azilect®)in treatment of Parkinson's disease [6,7], Clorgyline a drug used in depression treatment through monoaminooxidase A inhibition [8,9,10]. Furthermore, acetylenic compounds block H3 receptor and play important role in treatment of Alzheimer and other neurodegenerative disorders as seen with Perceptin [11].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and pharmacological evaluation of N-[4-(t-amino)-2- butynyloxy] phthalimides

Muhi-Eldeen¹,

Al‐Kaissi²,

Awad³

et al. 2012

iosrphr

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A series of aminoacetylenicoxyphthalimide namely N-[4-(t-amino)-2-butynyloxy] phthalimides were synthesized from the reaction of N-hydroxyphthalimide with propargyl bromide in sodium ethoxide to generate N-(2-butynyloxy)phthalimide. The desired compounds were prepared through Mannich reaction of N-(2-butynyloxy)phthalimide with formaldehyde, appropriate amine in peroxide-free dioxin and cuprous chloride as catalyst. The N-[4-(t-amino)-2-butynyloxy] phthalimides were investigated for their rectal temperature, motor activity and palpebral pitosis effects in comparison with harmaline, all compounds showed similar activity to harmaline, however compound 4 was more potent than harmaline.

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Non‐MAO A binding of clorgyline in white matter in human brain

Abstract: Clorgyline is an irreversible inhibitor of monoamine oxidase (MAO A) which has been labeled with carbon-11 (C-11) and used to measure human brain MAO A with positron emission tomography (PET). In this study we compared

Cited by 31 publications

References 26 publications

Evidence That Brain MAO A Activity Does Not Correspond to MAO A Genotype in Healthy Male Subjects

Evidence That Brain MAO A Activity Does Not Correspond to MAO A Genotype in Healthy Male Subjects

Brain Monoamine Oxidase A Activity Predicts Trait Aggression

Synthesis and pharmacological evaluation of N-[4-(t-amino)-2- butynyloxy] phthalimides

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