“…Indeed, characterizing the noise induced by an external complex system is of great relevance in many areas of nanotechnology, as well as in monitoring biological or chemical processes [5][6][7][8]. Besides, it represents a crucial step to design robust quantum protocols resilient to noise [9][10][11][12][13][14].The proper framework to address characterization by quantum probes [15,16], and to design the best working conditions, is given by quantum estimation theory [17], which provides analytical tools to optimize the three building blocks of an estimation strategy: (i) preparation of the probe system in a suitably optimized state, (ii) controlled interaction of the probe with the system for an optimal amount of time t, (iii) measurement of an optimal observable on the probe. Overall, the ultimate precision for any unbiased estimatorγ of a certain parameter γ is bounded by the quantum Cramèr-Rao (CR) theorem, stating that Var(γ) ≥ [M H(γ)] −1 , where M is the number of measurements and H(γ) is the quantum Fisher information (QFI), i.e.…”