Non-melanoma Skin Cancer – a Clinicopathological Study of Patients with Basal Cell Carcinoma and Squamous Cell Carcinoma

Abstract

SummaryBackground: Non-melanoma skin cancer (NMSC) is the most common malignancy in Caucasians. It mainly includes two major keratinocyte tumors -basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The objective of the study was to analyze and compare the clinicopathological differences between patients with BCC and SCC of the skin. Material and Methods: A cohort of 541 patients with a total of 719 BCCs, and 126 patients with a total of 162 SCCs were retrospectively analyzed. Results: While there was virtually the same proportion of men (49.91%) and women (50.09%) in BCC patients, SCCs occurred more frequently in men (68.2%) than in women (31.8%). The mean age of the individuals with BCC and SCC was 70.8 and 78.2 years, resp. The number of BCCs rises from 50 years of age and this increase showed a linear trend up to 80 years, subsequently followed by decline. SCC lesions occur more rapidly from 70 years of age followed by a sharp increase that exhibited an exponential relationship. BCCs and SCCs occurred predominantly on the head and neck region, compris ing a total of 69.8% and 81.4% of the cases, resp. However, BCC lesions were seen more often on the face and SCC lesions were dia gnosed more frequently on the extra-facial parts of the head. Further, BCCs occurred more frequently on the trunk, and particularly on the back, compared to SCCs. Conclusion: Although BCC and SCC are covered under common term NMSC, they manifest several clinicopathological differences. Despite shar ing common etiologic determinants, at least from the onco-epidemiologic perspective, they should be considered separately.

Detailed head localization and incidence of skin cancers

“…BCC and SCC are known as keratinocyte carcinoma (KC), historically termed non-melanoma skin cancers, which correspond to 95% of malignant skin tumors 3 , 5 . Although melanoma comprises only 1% of all skin cancers, it accounts for approximately 90% of deaths associated with cutaneous tumors 6 – 8 . BCC rarely results in death or metastatic disease, but can cause significant morbidity due to destructive local spread 9 .…”

Management and Clinico-Pathologic Aspects of Non-Melanoma Skin Cancer of the Head and Neck: A Retrospective Institutional Based Study at the Egyptian National Cancer Institute

“…In this study, patients over 50 years old represented 84.5% of the study population (mean 60, 6 years with the peak incidence in the sixth decade) in whom recurrence rate was significantly higher (p-value = 0.18), similarly some studies on NMSC detected a peak incidence in the sixth decade of life [10] [ [32]. Although Bartos and Kullova 2018 stated that BCC and SCC had several clinicopathological differences and should be considered separately [33], our study didn't show any significance regarding the distribution of both BCC and SCC in relation to different factors (Table 13).…”

Clinical value of high‐resolution dynamic contrast‐enhanced (DCE) MRI in diagnosis of cutaneous squamous cell carcinoma

“…Cutaneous squamous cell carcinoma (cSCC), which has become the second most common non‐melanoma skin cancer, is a kind of malignant tumors originating from epidermis or adnexal keratinocytes. With the increasing incidence in recent years, cSCC mainly occurs in the light‐exposed parts of the head, neck, hands and feet of the elderly over 50 years old and is easy to relapse and metastasis 1,2 and divided into: protuberant mass, deep infiltration, and ulcer type. Due to most of the typical cSCC show protruding masses on the surface of the skin, which can be found and treated earlier, there were few imaging reports regarding them 3 .…”