Non-melanoma skin cancer and solar keratoses II analytical results of the South Wales Skin Cancer Study

Harvey, Ian; Frankel, S; Marks, Robin; Shalom, Dara F.; Nolan-Farrell, M

doi:10.1038/bjc.1996.535

Cited by 91 publications

(70 citation statements)

References 14 publications

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“…This finding contrasts with results of investigations in Caucasians [2,12,13,14,15]. Women at that time had to work on the farm and were exposed to more sunlight than males.…”

Section: Discussioncontrasting

confidence: 56%

Clinical and Pathological Study of 328 Cases of Actinic Keratosis in Eastern Chinese Patients

Han

Chen²,

Dou³

et al. 2013

Dermatology

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Background: Actinic keratosis (AK) is prevalent and has been widely studied in fair-skinned populations. However, this is not the case in eastern countries. AK in Asians has not been so thoroughly investigated. Objectives: To analyse the clinical and pathological features of a relatively large number of cases of AK diagnosed in older Chinese patients. Methods: Case histories of 328 patients with pathologically diagnosed AK were analysed retrospectively. Their demographic, clinical, pathological and treatment data were collected for analysis of associated factors. Results: Lesions were usually distributed on the face, especially the cheeks and temples. The most frequent pathological type was hypertrophic. Only 34% of the cases had been diagnosed correctly as AK before biopsy; many were mistaken for seborrhoeic keratosis. Conclusions: Most patients were elderly females and there was a higher incidence of lesions on the face, and a lower incidence on the extremities and trunk; this finding contrasts with previous investigations in fair-skinned people.

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“…This finding contrasts with results of investigations in Caucasians [2,12,13,14,15]. Women at that time had to work on the farm and were exposed to more sunlight than males.…”

Section: Discussioncontrasting

confidence: 56%

Clinical and Pathological Study of 328 Cases of Actinic Keratosis in Eastern Chinese Patients

Han

Chen²,

Dou³

et al. 2013

Dermatology

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“…Other findings, principally the analytical epidemiological results and an evaluation of preventive measures including sunscreen use, will be presented in a companion paper (Harvey et al, 1996). These descriptive findings provide important baseline data, comparison with which will allow, in due course, an overall evaluation of the current programme of primary skin cancer prevention in the UK.…”

mentioning

confidence: 97%

“…The first two objectives will be dealt with in this paper and the third and fourth in a companion paper (Harvey et al, 1996). (Frost and Green, 1994) and over 75% of NMSCs (Gallagher et al, 1990;Chuang et al, 1990) occur on sun-exposed areas of the skin, this limited skin examination gave a high probability of detecting lesions with minimum disruption and embarrassment for these elderly study subjects.…”

mentioning

confidence: 99%

Non-melanoma skin cancer and solar keratoses. I. Methods and descriptive results of the South Wales Skin Cancer Study

Harvey

Frankel²,

Marks³

et al. 1996

Br J Cancer

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115

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Summary This study aimed to describe the prevalence and incidence of solar keratoses and skin cancers and the natural history of solar keratoses in a random population sample. It was a cross-sectional study, with follow-up, conducted in South Wales, and involved 1034 subjects aged 60 years and over drawn from the Family Health Services Authority register. The main outcome measures were detection of the presence of solar keratoses and skin cancers on sun-exposed skin and photographic validation of solar keratoses and biopsy confirmation of cancers wherever possible. We found that solar keratosis prevalence was 23% (95% confidence interval 19.5-26.5) and that of skin cancer (all types) 2% (95% confidence interval 1.0-3.5). The incidence rate of solar keratoses was 149 lesions per 1000 person-years and of non-melanoma skin cancer 9 per 1000 person-years. In all 21% (95% CL 16-26) of solar keratoses regressed spontaneously during follow-up. None underwent malignant change. We believe that the failure of individuals to seek medical advice and the variable under-registration of non-melanoma skin cancer makes population-based study important. The high prevalence and incidence of malignant and pre-malignant skin lesions in this random sample raise major public health concerns. The high rate of spontaneous regression of solar keratoses and the low rate of malignant change challenges conventional views about the need for routine treatment of these lesions.

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“…We conducted cognitive interviewing and validation with a typical population of AK patients with a majority being elderly males [5, 8, 10]. Our patient characteristics are in line with the mean age of other AKQoL populations: 69 years for the original Danish questionnaire [13], 71 years within Tennvall’s [35, 36] and a median age of 71 years within Alarcon’s population [37].…”

Section: Discussionmentioning

confidence: 81%

Swiss (German) Version of the Actinic Keratosis Quality of Life questionnaire

et al. 2018

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Background: Actinic keratosis (AK) is a sun-induced skin lesion that may progress to invasive squamous cell carcinoma of the skin. Recently, the Actinic Keratosis Quality of Life questionnaire (AKQoL) was designed for patients with AK in Denmark as a specific quality of life instrument for AK patients. Objective: The objective of this study was to adapt the AKQoL for the German language region of Switzerland and to evaluate its psychometric properties (validity, reliability). Methods: Translation and cultural adaptation of the questionnaire were assessed by using the technique of cognitive interviewing. During the translation process, 34 patients with AK from the Department of Dermatology, University Hospital Zurich, were interviewed in 3 sessions of cognitive interviewing. The translated questionnaire was then distributed together with the Dermatology Life Quality Index (DLQI) to a second group of 113 patients for validation and reliability testing. Within this group, we measured the internal consistency by the Cronbach coefficient α and Spearman correlation coefficient between the AKQoL and the DLQI. Results: The problems encountered during the translation process led to changes in 5 categories as described by Epstein: stylistic changes, change in breadth, change in actual meaning, change in frequency and time frame, change in intensity. We found a Cronbach α of 0.82, an acceptable internal consistency. The Spearman correlation coefficient between total scores of AKQoL and DLQI was 0.57. Conclusion: We culturally adapted and validated a Swiss (German) version of the AKQoL questionnaire applicable for the population of a university center in Switzerland to measure and monitor the quality of life in patients with AK.

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Non-melanoma skin cancer and solar keratoses II analytical results of the South Wales Skin Cancer Study

Abstract: Summary This study aimed to identify risk markers for prevalent solar keratoses (SKs)

Cited by 91 publications

References 14 publications

Clinical and Pathological Study of 328 Cases of Actinic Keratosis in Eastern Chinese Patients

Clinical and Pathological Study of 328 Cases of Actinic Keratosis in Eastern Chinese Patients

Non-melanoma skin cancer and solar keratoses. I. Methods and descriptive results of the South Wales Skin Cancer Study

Swiss (German) Version of the Actinic Keratosis Quality of Life questionnaire

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