2018
DOI: 10.1159/000486477
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Non-Melanoma Skin Cancers at Sites of Previous Frostbite: Case Report and Review

Abstract: The association between ultraviolet radiation exposure and skin cancer is well established. Limited studies have reported an association between frostbite and the development of non-melanoma skin cancer but evidence for a proven link is insufficient and possible carcinogenic mechanisms have not been fully explored. In this report, 3 cases of non-melanoma skin cancer (1 case of basal cell carcinoma and 2 cases of squamous cell carcinoma of the skin) which developed at a site of previous frostbite caused by expo… Show more

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Cited by 6 publications
(4 citation statements)
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“…Long-term sequelae include subchondral bone loss, osteoporosis, arthritis, scarring, atrophy, neuropathy, dysesthesia, pain, and cold hypersensitivity 13–16,35–37 . Cases of skin cancer and chronic ulceration have also been reported on previously frostbitten areas 15,16,38 . When sustained before physeal closure, frostbite can result in permanent bone, joint, and physeal damage (Fig.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Long-term sequelae include subchondral bone loss, osteoporosis, arthritis, scarring, atrophy, neuropathy, dysesthesia, pain, and cold hypersensitivity 13–16,35–37 . Cases of skin cancer and chronic ulceration have also been reported on previously frostbitten areas 15,16,38 . When sustained before physeal closure, frostbite can result in permanent bone, joint, and physeal damage (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…[13][14][15][16][35][36][37] Cases of skin cancer and chronic ulceration have also been reported on previously frostbitten areas. 15,16,38 When sustained before physeal closure, frostbite can result in permanent bone, joint, and physeal damage (Fig. 2A-B).…”
Section: Classification and Clinical Manifestationsmentioning
confidence: 99%
“…Eine Kasuistik beschreibt die Entstehung von weißem Hautkrebs auf einer durch Erfrierung vorgeschädigten Haut in einer Gruppe von 3 Patienten, wobei in 2 Fällen ein Plattenepithelkarzinom diagnostiziert wurde [8], nicht jedoch die Entstehung einer Sarkoidose auf dem Boden dieser Schädigung. Häufiger beschrieben ist ein Zusammenhang zwischen thermischer Verbrennung und Malignität, wobei ein Review über Neoplasien in Brandnarben zeigte, dass das Plattenepithelkarzinom mit 71 % die häufigste Tumorart bei dieser Art der physikalischen Vorschädigung darstellte [9].…”
Section: Diskussionunclassified
“…Cold injuries can result in long-term changes in muscle, skin, nails, ligaments, and bones [ 13 ]. Limited evidence suggests an association between frostbite scars and non-melanoma skin cancers [ 14 ]. Neurologic complications (neuralgia, paresthesia in the extremities, sensations of hot or cold) and vascular injuries (e.g., Reynaud’s phenomenon) can also be long-term sequelae.…”
Section: Reviewmentioning
confidence: 99%