2023
DOI: 10.1097/md.0000000000035571
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Non-metabolic enzyme function of PKM2 in hepatocellular carcinoma: A review

Shuangxia Zhang,
Zhangxiu Liao,
Shubo Li
et al.

Abstract: Hepatocellular carcinoma (HCC) is one of the most malignant tumors with the highest incidence and mortality in the world, causing a serious burden on society. Pyruvate kinase M2 (PKM2) is one of the principal metabolic enzymes involved in glycolysis. Studies have shown that PKM2 is highly expressed in HCC and can be translocated to the nucleus, where it interacts with various transcription factors and proteins such as hypoxia-inducible factor-1α, sterol regulatory element-binding protein 1a, signal transducer … Show more

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Cited by 3 publications
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“…Another pathway is the loss of senescence control, the irreversible growth inhibition of the cells at DNA checkpoint. The genetically altered cells will proliferate [17,18].…”
Section: Molecular Mechanism Of Hccmentioning
confidence: 99%
“…Another pathway is the loss of senescence control, the irreversible growth inhibition of the cells at DNA checkpoint. The genetically altered cells will proliferate [17,18].…”
Section: Molecular Mechanism Of Hccmentioning
confidence: 99%