Non-motor features of cervical dystonia: Cognition, social cognition, psychological distress and quality of life

Monaghan, Ruth; Cogley, Clodagh; Burke, Tom; McCormack, Derval; O’Riordan, Sean; Ndukwe, Ihedinachi; Hutchinson, Michael; Pender, Niall; O’Keeffe, Fiadhnait

doi:10.1016/j.prdoa.2020.100084

Cited by 22 publications

(44 citation statements)

References 48 publications

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“…In the current study, pain/discomfort was reported by 68.2% of the patients with CD. Inconsistent with our results, pain has also been identified to affect the quality of life in patients with CD in several studies ( 7 – 9 , 11 – 13 ). The pain in CD can be relieved by botulinum toxin injection ( 28 ).…”

Section: Discussionsupporting

confidence: 91%

“…Depression was another determinant of decreased HRQoL in patients with CD identified in the current study. Mood disorders have been reported to be important determinants of poor quality of life in patients with CD in many previous studies (5,(8)(9)(10)(11)13). Depression is common in patients with CD.…”

Section: Discussionmentioning

confidence: 98%

“…Additionally, they had usually small sample sizes and yielded inconsistent results. For example, motor severity has been reported to correlate with poor quality of life in CD in some studies (5-7), but not in other studies (8)(9)(10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 97%

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Health-Related Quality of Life in Cervical Dystonia Using EQ-5D-5L: A Large Cross-Sectional Study in China

et al. 2022

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PurposeThe study aimed to evaluate the health-related quality of life (HRQoL) measured by the five-level EuroQol-5 dimensions (EQ-5D-5L) in patients with cervical dystonia, and to explore the determinants of HRQoL in patients with cervical dystonia.MethodsEQ-5D-5L health state profiles were converted into a single aggregated “health utility” score. A calibrated visual analog scale (EQ VAS) was used for self-rating of current health status. Multiple linear regression analysis was used to explore the factors associated with HRQoL in cervical dystonia.ResultsA total of 333 patients with cervical dystonia were enrolled in the analysis, with an average age of 44.3 years old. The most common impaired dimension of health was anxiety/depression (73.6%), followed by pain/discomfort (68.2%) and usual activities (48%). The median health utility score was 0.80, and the median EQ VAS score was 70.2. Multivariate linear regression analysis indicated that disease duration and the scores of the Hamilton Depression Rating Scale (HDRS), Pittsburgh sleep quality index (PSQI), Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) Part I, and TWSTRS Part III were associated with the health utility scores. After adjusting other parameters, the TWSTRS Part III score and the HDRS score were significantly associated with the EQ VAS scores (p < 0.05).ConclusionThis study evaluated HRQoL in patients with cervical dystonia using the Chinese version of the EQ-5D-5L scale. We found that, besides motor symptoms, non-motor symptoms, including depression, pain, and sleep quality, could be greater determinants of HRQoL in patients with cervical dystonia. Management of non-motor symptoms, therefore, may help improve HRQoL in patients with cervical dystonia.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 98%

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Health-Related Quality of Life in Cervical Dystonia Using EQ-5D-5L: A Large Cross-Sectional Study in China

et al. 2022

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“…Отчасти сходные данные были получены в работе R. Monaghan и соавт. [24], где были выявлены статистически значимые связи между снижением КЖ и результатами выполнения тестов на когнитивные управляющие функции. Оценки управляющих функций, по данным авторов, как и в нашей работе, не коррелировали с выраженностью боли, тяжестью двигательных симптомов.…”

Section: Results Of Assessment Of the Relationship Between Qol Indica...unclassified

“…О Р И Г И Н А Л Ь Н Ы Е И С С Л Е Д О В А Н И Я И М Е Т О Д И К И Неврология, нейропсихиатрия, психосоматика. 2022;14(3): [19][20][21][22][23][24][25]…”

Section: Results Of Assessment Of the Relationship Between Qol Indica...unclassified

The impact of non-motor disorders on the quality of life of patients with cervical muscular dystonia

Nodel

Salouhina

Толмачева

2022

RJTAO

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Cervical dystonia (CD) has a wide range of non-motor (neuropsychiatric, sensory, dyssomnic) disorders. Relationships between dystonia, nonmotor manifestations of the disease and patients quality of life (QoL) require clarification.Objective: to clarify the impact of dystonia, sensory, affective, behavioral disorders, quality of sleep and wakefulness on the quality of life of patients with CD.Patients and methods. We examined 61 patients with CD (mean age – 48.03±11.49 years, mean duration of CD – 4.89±4.05 years). We used Toronto Western Hospital Spasmodic Torticollis Rating Scale (TWSTRS), Cervical Dystonia Quality of Life Questionnaire (CDQ-24, with five subscales: «stigma», «emotional wellbeing», «pain», «activities of daily living», «social/family life»), Spielberger–Khanin Inventory (STAI),Beck Depression Inventory (BDI), Barratt Behavioral Impulsivity (BIS-11), Yale–Brown Obsessive Compulsive Scale (Y-BOCS), Montreal Cognitive Assessment Scale (MoCA), Stroop Test (VST), 12 Word Memory Test, Pittsburgh Sleep Quality Assessment Scale (PSQI), Epworth Sleepiness Scale (ESS).Results and discussion. There was a deterioration in all characteristics of QoL in patients with CD, largely in emotional well-being, stigmatization, pain syndrome (50% change from the maximum CDQ-24 score). A statistically significant moderate correlation was established between the total assessment of QoL and the severity of dystonia (r=0.35; p<0.01), a statistically significant strong correlation between the total assessment of QoL and depression index (r=0.73; p<0.001 ), moderate strength correlation – with indicators of anxiety (r=0.65; p<0.01), obsessivecompulsive disorders (r=0.61; p<0.01), sleep quality (r=0.52; p<0.001), impulsiveness in behavior (r=0.31; p<0.01), weak relationship with the assessment of executive cognitive functions (according to the Stroop test interference index; r=0.24; p<0.01). A statistically significant moderate correlation was found between the assessments of activity in everyday, social/family life and impulsiveness in behavior (r=0.33; p<0.001); between stigma, emotional well-being and an indicator of executive cognitive functions (r=0.3; p<0.05). There were no statistically significant relationships between indicators of affective, cognitive functions, behavioral disorders and the severity of dystonia. There was a moderate correlation between pain score and dystonia severity (r=0.35; p<0.01).Conclusion. The decrease in QoL in patients with CD is largely due to affective, sensory, and behavioral disorders. Diagnosis and appropriate therapy of the non-motor aspects of the disease are required for adequately improvement of QoL of patients.

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Social Cognition Deficits in Cervical Dystonia, but not Blepharospasm: Focal Dystonias Diverge

Feuerstein,

Heffernan,

Holden

et al. 2023

Movement Disord Clin Pract

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Non-motor features of cervical dystonia: Cognition, social cognition, psychological distress and quality of life

Abstract: Highlights For some patients, deficits in cognitive functioning are a distinct feature of CD. Pain and psychological distress are associated with poorer HR-QOL. High levels of depression and anxiety were observed. Findings highlight the importance of addressing non-motor symptoms of CD.

Cited by 22 publications

References 48 publications

Health-Related Quality of Life in Cervical Dystonia Using EQ-5D-5L: A Large Cross-Sectional Study in China

Health-Related Quality of Life in Cervical Dystonia Using EQ-5D-5L: A Large Cross-Sectional Study in China

The impact of non-motor disorders on the quality of life of patients with cervical muscular dystonia

Social Cognition Deficits in Cervical Dystonia, but not Blepharospasm: Focal Dystonias Diverge

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