Non-motor symptoms in early Parkinson's disease: a 2-year follow-up study on previously untreated patients

Erro, Roberto; Picillo, Marina; Vitale, Carmine; Amboni, Marianna; Moccia, Marcello; Longo, Katia; Cozzolino, Autilia; Giordano, Flavio; Rosa, Anna De; Michele, Giuseppe De; Pellecchia, Maria Teresa; Barone, Paolo

doi:10.1136/jnnp-2012-303419

Cited by 96 publications

(86 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although a few studies did assess NMS among patients with untreated, de novo PD, 5-8 most did not have sufficient sample size to evaluate potential sex differences [5][6][7] or focused executively on one or a limited number of specific…”

Section: Methodsmentioning

confidence: 99%

“…3,4 However, most previous studies of NMS used hospital-based prevalent PD cases, had small sample sizes, and often lacked a comparable control group. Although a few studies did assess NMS among patients with untreated, de novo PD, 5-8 most did not have sufficient sample size to evaluate potential sex differences [5][6][7] or focused executively on one or a limited number of specific symptoms. Therefore, little is known about the burden of the wide spectrum of NMS in patients with de novo, untreated PD.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Potential sex differences in nonmotor symptoms in early drug-naive Parkinson disease

Umbach

Peddada

et al. 2015

Neurology

View full text Add to dashboard Cite

Objective: To examine potential sex differences in nonmotor symptoms (NMS) among drug-naive patients with Parkinson disease (PD), and to identify NMS that can best differentiate patients with early PD from controls. Methods:Our cross-sectional analysis included 414 newly diagnosed, untreated patients with PD (269 men and 145 women) and 188 healthy controls (121 men and 67 women) in the Parkinson's Progression Markers Initiative Study. NMS were measured using well-validated instruments covering sleep, olfactory, neurobehavioral, autonomic, and neuropsychological domains.Results: Male and female patients with PD were fairly comparable on motor presentations but differed on several nonmotor features. Male patients with PD had significantly more pronounced deficits in olfaction (p 5 0.02) and in certain cognitive measurements (all p , 0.01) than female patients, whereas female cases experienced higher trait anxiety (p 5 0.02). Multiple stepwise logistic regression analysis showed that the combination of NMS measures-University of Penn- Conclusions: Our analysis revealed notable sex differences in several nonmotor features of patients with de novo PD. Furthermore, we found a parsimonious NMS combination that could effectively differentiate de novo cases from healthy controls. Nonmotor symptoms (NMS) are common among patients with Parkinson disease (PD) 1 and contribute greatly to poor quality of life, morbidity, and mortality.2,3 Despite their significant impacts, NMS among patients with PD remain poorly understood and, consequently, undertreated.2 Furthermore, some NMS, such as hyposmia, depression, REM sleep behavior disorder (RBD), and constipation, may even precede PD clinical diagnosis by years.Clinical and epidemiologic studies have increasingly recognized and investigated the importance of NMS in understanding the natural history, etiology, and clinical care of PD.3,4 However, most previous studies of NMS used hospital-based prevalent PD cases, had small sample sizes, and often lacked a comparable control group. Although a few studies did assess NMS among patients with untreated, de novo PD, 5-8 most did not have sufficient sample size to evaluate potential sex differences [5][6][7] or focused executively on one or a limited number of specific

show abstract

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

Potential sex differences in nonmotor symptoms in early drug-naive Parkinson disease

Umbach

Peddada

et al. 2015

Neurology

View full text Add to dashboard Cite

show abstract

“…Reports of selective, longitudinal investigations of nonmotor signs (NMS), [6][7][8] neuroimaging, and laboratory analyses 9 have been previously published as potential markers of progression. 10 These investigations were largely conducted in smaller cohorts and focused on single symptoms/measures and frequently relied on more advanced PD cases, and lacked age-matched healthy controls.…”

mentioning

confidence: 99%

Monitoring of 30 marker candidates in early Parkinson disease as progression markers

Mollenhauer¹,

Zimmermann²,

et al. 2016

View full text Add to dashboard Cite

Objective: This was a longitudinal single-center cohort study to comprehensively explore multimodal progression markers for Parkinson disease (PD) in patients with recently diagnosed PD (n 5 123) and age-matched, neurologically healthy controls (HC; n 5 106).Methods: Thirty tests at baseline and after 24 months covered nonmotor symptoms (NMS), cognitive function, and REM sleep behavior disorder (RBD) by polysomnography (PSG), voxel-based morphometry (VBM) of the brain by MRI, and CSF markers. Linear mixed-effect models were used to estimate differences of rates of change and to provide standardized effect sizes (d) with 95% confidence intervals (CI). Conclusions: Current CSF biomarkers and cognitive scales do not represent useful progression markers. However, sleep and imaging measures, and to some extent NMS, assessed using adequate scales, may be more informative markers to quantify progression. Results:

show abstract

“…Compounding the group of non-motor symptoms, behavioral alterations caused by dopamine disregulation can be characterized by hypersexuality, compulsive jealousy, dysphoria, gambling, among others (13) . When considering the rehabilitation program, attention to this diagnosis becomes necessary for interventionist actions that require team decision making together, because in this case there is important discussion between the nurse and the medical team for medical setting, and the psychology team for guidance on the management of symptoms (2,12,20) . Likewise, we highlight the changes in memory, which are also considered non-motor symptoms and are related to the more advanced stages of PD.…”

Section: Discussionmentioning

confidence: 99%

Mapping Nursing language terms of Parkinson's disease

Tosin

Campos

Blanco

et al. 2015

Rev. esc. enferm. USP

View full text Add to dashboard Cite

Objective: Implementing cross-mapping of Nursing language terms with the terminology of NANDA International, contained in records of patients with Parkinson's disease in rehabilitation. Method: Descriptive study of cross mapping, carried out in three steps. A simple random sample of 67 files of patients who participated in the rehabilitation in the period between March 2009 and April 2013. Results: We identified 454 terms of Nursing language that resulted in 54 diagnoses after cross-mapping, present in 11 of the 13 taxonomy domains. The most mapped diagnosis was "Impaired urinary elimination" (59.7%), followed by "Urgent urinary incontinence" (55.2%), "Willingness to self-control improved health" (50.7%), "Constipation" (47.8%) and "Compromised physical mobility" (29.9%). Seven described terms were not mapped due to a corresponding defining characteristic being absent. Conclusion: It was possible to determine the profile of patients, as well as the complexity of nursing care in the rehabilitation of patients with Parkinson's disease.

show abstract

Non-motor symptoms in early Parkinson's disease: a 2-year follow-up study on previously untreated patients

Cited by 96 publications

References 33 publications

Potential sex differences in nonmotor symptoms in early drug-naive Parkinson disease

Potential sex differences in nonmotor symptoms in early drug-naive Parkinson disease

Monitoring of 30 marker candidates in early Parkinson disease as progression markers

Mapping Nursing language terms of Parkinson's disease

Contact Info

Product

Resources

About