Non-myeloproliferative Pancytopenia: A Rare Presentation of Thyrotoxicosis

Abstract

Thyrotoxicosis-induced pancytopenia is a rare manifestation. The practical challenge is to differentiate thyrotoxicosis-induced pancytopenia from the side effects of anti-thyroid treatment following the commencement of treatment. Although some of the possible underlying pathogeneses have been reported, the complete mechanisms remain unclear concerning pancytopenia in uncontrolled thyrotoxicosis. Thyrotoxicosis-induced pancytopenia is completely reversible with the administration of anti-thyroid drugs at an appropriate time and regular follow-up to prevent further recurrence.

Graves' disease with pancytopenia: A rare case report

“…The sequestration of immature erythroid cells can lead to all types of anemia by dramatically increasing the intake of vitamin B12, iron, and folic acid (Table 2). 17 …”

“…The sequestration of immature erythroid cells can lead to all types of anemia by dramatically increasing the intake of vitamin B12, iron, and folic acid (Table 2). 17 There are some reports regarding hyperthyroid patients who present with pancytopenia. 1,4,5,[14][15][16] Most such cases have been associated with Graves' disease indicating that both hyperthyroidism and autoimmunity can lead to pancytopenia in GD patients.…”