Non-O1, non-O139 Vibrio cholerae bacteraemia in a cirrhotic patient

Abstract

Vibrio cholerae serogroups O1 or O139 are the aetiological agents of cholera. The pathogenicity of non-O1, non-O139 V. cholerae is less well known. These worldwide bacteria are responsible for gastrointestinal infections or, more rarely, bacteraemia in patients with an underlying disease, leading to life-threatening complications. We report a case of non-O1, non-O139 V. cholerae bacteraemia due to a haemolytic strain in a cirrhotic patient. Early antibiotherapy allowed a good outcome. The aim of this case report is to underline the virulence of non-choleragenic Vibrio strains, possibly linked to haemolysin production, and the potential danger of consuming undercooked seafood or exposing wounds to sea water in cirrhotic patients.

Fatal Diarrheal Disease Caused by <i>Vibrio cholerae</i> O67 in a Patient with Myelodysplastic Syndrome

“…On the other hand, the administration of antibiotic therapy for Vibrio cholerae non-O1-induced bacteremia associated with hepatic cirrhosis decreases the mortality rate (21). In addition, providing early antibiotic therapy for bacteremia in a cirrhotic patient resulted in a good outcome, as reported by Petsaris et al (12). The Vibrio cholerae O67 isolates obtained in this case were sensitive to most of the antibiotics tested.…”

“…Hepatic cirrhosis, in particular, can readily cause Vibrio cholerae non-O1-induced bacteremia, with a mortality rate of approximately 50% (6,8,12). Hematological diseases have also been reported to cause Vibrio cholerae non-O1/non-O139-induced bacteremia (6,13,14).…”

Non‐O1, non‐O139 Vibrio cholerae bacteraemia in an Australian population

“…Bacteraemia with non‐O1, non‐O139 V. cholerae has been reported following the consumption of seafood . Invasive non‐O1, non‐O139 V. cholerae has a global impact with cases of bacteraemia noted in Europe, Asia, USA/Canada and Australia (Table ).…”

Bullous cellulitis in cirrhotic patients – a rare but life-threatening infection caused by non-O1, non-O139 Vibrio cholerae bacteraemia

“…The article by Petsaris et al (2010) regarding non-O1 Vibrio cholerae bacteraemia in a cirrhotic patient is interesting. Recently, we encountered a cirrhotic patient with small cell lung cancer who was admitted to our hospital because of superior vena cava syndrome and underwent concurrent radiotherapy and chemotherapy.…”

“…The O1 or O139 biotypes of V. cholerae may cause cholera and severe diarrhoea. However, non-O1, non-O139 V. cholerae causes not only diarrhoea but also extraintestinal infections such as cellulitis or bacteraemia, which often occur in immunocompromised patients, such as patients with cirrhosis (Cheng et al, 2004;Halabi et al, 1997;Ko et al, 1998;Lin et al, 1996;Petsaris et al, 2010), transplantation (Choi et al, 2003) and malignancy (Berghmans et al, 2002). V. cholerae bacteraemia is rare but critical because the mortality rates are extremely high, ranging from 23.8 % to 47 % (Jabeen et al, 2010;Ko et al, 1998;Lin et al, 1996).…”