Non-O1Vibrio cholerae bacteremia in an infant, first case report from Pakistan

Sarwar, Syed Mansoor; Hannan, Abdul; Sultana, Qamar; Saleem, Sidrah; Sohail, Muhammad; Arshad, Muhammad Usman; Rasool, Karam

doi:10.3855/jidc.6554

Cited by 8 publications

(4 citation statements)

References 5 publications

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“…11,12,13,14 The majority of these cases (7/8) presented with meningoencephalitis and had residual neurological deficits following infection. 11,12,13,14) In the remaining case, 15 the patient presented with fever, did not have a LP and demised in hospital. This is in contrast with the clinical findings in our case, where the patient recovered well, had a normal CSF analysis, had a negative repeat blood culture (whilst on empiric antibiotics) and had a repeat CRP that was not elevated.…”

Section: Discussionmentioning

confidence: 97%

Non-toxigenic Vibrio cholerae non-O1/non-O139 pseudo-bacteraemia in a neonate: A case report

Dowling

Westhuyzen

Haumann³

et al. 2021

Southern African Journal of Infectious Diseases

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Toxigenic Vibrio cholerae O1/O139 is causative of cholera, which is a well characterised potentially epidemic gastrointestinal disease. Less is known about the pathogenesis and clinical presentation of non-toxigenic V. cholerae non-O1/non-O139, although they are increasingly implicated in human disease globally, have been isolated from various South African water sources and can contaminate the environment. The authors describe a case of pseudo-bacteraemia with non-toxigenic V. cholerae non-O1/non-O139 in a neonate.

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Section: Discussionmentioning

confidence: 97%

Non-toxigenic Vibrio cholerae non-O1/non-O139 pseudo-bacteraemia in a neonate: A case report

Dowling

Westhuyzen

Haumann³

et al. 2021

Southern African Journal of Infectious Diseases

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“…Phylogenetic relationship among the strains The current results are in agreement with published reports 11 . It has been reported that clinical isolate of V. cholera from a patient in the United States who visited Pakistan, was a variant strain with deletion of VP1 21,22 . Similar reports about El Tor variants has already been published from Haiti, Asia Africa and Bangladesh and Mexico.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Vibrio cholerae O1 El Tor variants circulating in Sindh Pakistan

Mughal

Kazi²,

Bokhari³

et al. 2022

J Pak Med Assoc

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Objective: To investigate the existence of genetically diverse vibrio cholerae variant strains in a rural Sindh district, and to find out the phylogenetic relationship of indigenous vibrio cholerae strains. Methods: The cross-sectional study was conducted from April 2014 to May 2016 in Khairpur, Pakistan, and comprised stool samples/rectal swabs collected from the main and city branches of the Khairpur Medical College Teaching Hospital, and the Pir Abdul Qadir Shah Jeelani Institute of Medical Sciences, Gambat. The samples were identified using standard microbiological, biochemical, serological techniques and polymerase chain reaction targeting the ompW gene. Whole genome sequencing and bioinformatics tool MUMmer 3.2.3 was used to compare indigenous and contemporary vibrio cholerae strains circulating in the province of Sindh. Neighbour-joining tree method was used to construct the phylogenic tree. Results: Of the 360 samples, 76(21.11%) were found positive for vibrio cholera strains. The species-specific ompW gene was amplified at the correct size of 588bp. The isolates belonged to serogroup Inaba, O1, biotype El Tor. Unique sequences with same genomic coordinates showed that test strains were not similar to the reference sequence. Conserved genome sequences showed that 12 Out of 16 (75%) of the test strains were similar to each Other except the 3 strains isolated from Khairpur and 1 from Karachi. Multiple sequence alignment of the regions translated into protein showed that 13 out of 16 (81.25%) test strains were similar except 2 strains from Khairpur and 1 From Karachi. The phylogenetic tree showed that all isolated strains descended from the same ancestor along with the reference strain. Conclusions: Vibrio cholerae O1 El Tor variant existed in Khairpur. Key Words: Cholera, Vibrio cholerae, Variant, Khairpur, Phylogeny, MUMmer.

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“…Our review included 23 cases of NOVC bacteremia described in 18 reports from 2015-2019 (Table 2). [1][2][3][4][5]7,[10][11][12][13][14][15][16][17][18][19][20][21] The male-to-female ratio was 3.6:1, and the median age was 56 years. The youngest patient developed this disease at only 3 days of age, and the oldest patient was 83 years old.…”

Section: Discussion Epidemiologymentioning

confidence: 99%

<p>Non-O1, Non-O139 <em>Vibrio cholerae</em> (NOVC) Bacteremia: Case Report and Literature Review, 2015–2019</p>

Zhang¹,

Lu²,

Qian³

et al. 2020

IDR

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Non-O1, non-O139 Vibrio cholerae (NOVC) does not agglutinate with O1 and O139 antisera and can cause intestinal and extraintestinal infections in immunocompromised individuals. NOVC bacteremia has the highest mortality among NOVC infections, and the number of reports has increased in recent years. Nevertheless, some clinicians are poorly informed about this disease. Herein, we describe a documented case of NOVC bacteremia in a male patient with impaired liver function. Blood cultures revealed the presence of V. cholerae, but this strain showed self-coagulation on the serum agglutination test. To our knowledge, this phenomenon is unreported among cases of NOVC infections. This pathogen was finally confirmed as NOVC via PCR. Because the patient worked as a garbage transporter, he was likely infected after contact with contaminated water through a foot wound. The patient developed septic shock shortly after admission and ultimately died from the illness. This paper reviews 23 cases of NOVC bacteremia from 2015 to 2019. To improve the accuracy of identifying NOVC and analyze its virulence factors, relevant detection methods were reviewed and analyzed.

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Non-O1Vibrio cholerae bacteremia in an infant, first case report from Pakistan

Cited by 8 publications

References 5 publications

Non-toxigenic Vibrio cholerae non-O1/non-O139 pseudo-bacteraemia in a neonate: A case report

Non-toxigenic Vibrio cholerae non-O1/non-O139 pseudo-bacteraemia in a neonate: A case report

Evaluation of Vibrio cholerae O1 El Tor variants circulating in Sindh Pakistan

<p>Non-O1, Non-O139 <em>Vibrio cholerae</em> (NOVC) Bacteremia: Case Report and Literature Review, 2015–2019</p>

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