Non-Oncologic Applications of Nanomedicine-Based Phototherapy

Yoo, Su Woong; Oh, Gyungseok; Ahn, Jin Ho; Chung, Euiheon

doi:10.3390/biomedicines9020113

Cited by 38 publications

(26 citation statements)

References 213 publications

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“…For instance, PDT is used to treat multiple dermatological and infectious diseases such as psoriasis vulgaris, Darier’s disease (DAR), cutaneous sarcoidosis (granulomatous disease), lichen planus, acne vulgaris, acne inversa, rosacea, sebaceous hyperplasia, verrucae vulgaris, cutaneous leishmaniasis, condyloma acuminatum (genital warts), and circumscribed scleroderma ( Karrer and Szeimies, 2007 ; Babilas et al, 2010 ; Kharkwal et al, 2011 ; Queiros et al, 2020 ). In addition, PDT is used as a treatment method for dental ailments such as periodontitis, cardiovascular diseases such as atherosclerosis, esophageal varices, and neurological disorders such as Alzheimer’s disease and prion diseases ( Meisel and Kocher, 2005 ; Al Habashneh et al, 2015 ; Yoo et al, 2021 ). Ophthalmologic conditions such as age-related macular degeneration (AMD), choroidal neovascularization (CNV, pathological myopia), gastrointestinal diseases such as Crohn’s disease, and musculoskeletal disorders such as rheumatoid arthritis and synovitis might be treated with PDT ( Rivellese and Baumal, 2000 ; Yoo et al, 2021 ).…”

Section: Mechanisms Of Actionmentioning

confidence: 99%

“…In addition, PDT is used as a treatment method for dental ailments such as periodontitis, cardiovascular diseases such as atherosclerosis, esophageal varices, and neurological disorders such as Alzheimer’s disease and prion diseases ( Meisel and Kocher, 2005 ; Al Habashneh et al, 2015 ; Yoo et al, 2021 ). Ophthalmologic conditions such as age-related macular degeneration (AMD), choroidal neovascularization (CNV, pathological myopia), gastrointestinal diseases such as Crohn’s disease, and musculoskeletal disorders such as rheumatoid arthritis and synovitis might be treated with PDT ( Rivellese and Baumal, 2000 ; Yoo et al, 2021 ). In addition, it has been proposed that PDT can be an effective method in treating respiratory diseases such as pneumonia and COVID-19 ( Yoo et al, 2021 ).…”

Section: Mechanisms Of Actionmentioning

confidence: 99%

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Photodynamic Therapy—Current Limitations and Novel Approaches

2021

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Photodynamic therapy (PDT) mostly relies on the generation of singlet oxygen, via the excitation of a photosensitizer, so that target tumor cells can be destroyed. PDT can be applied in the settings of several malignant diseases. In fact, the earliest preclinical applications date back to 1900’s. Dougherty reported the treatment of skin tumors by PDT in 1978. Several further studies around 1980 demonstrated the effectiveness of PDT. Thus, the technique has attracted the attention of numerous researchers since then. Hematoporphyrin derivative received the FDA approval as a clinical application of PDT in 1995. We have indeed witnessed a considerable progress in the field over the last century. Given the fact that PDT has a favorable adverse event profile and can enhance anti-tumor immune responses as well as demonstrating minimally invasive characteristics, it is disappointing that PDT is not broadly utilized in the clinical setting for the treatment of malignant and/or non-malignant diseases. Several issues still hinder the development of PDT, such as those related with light, tissue oxygenation and inherent properties of the photosensitizers. Various photosensitizers have been designed/synthesized in order to overcome the limitations. In this Review, we provide a general overview of the mechanisms of action in terms of PDT in cancer, including the effects on immune system and vasculature as well as mechanisms related with tumor cell destruction. We will also briefly mention the application of PDT for non-malignant diseases. The current limitations of PDT utilization in cancer will be reviewed, since identifying problems associated with design/synthesis of photosensitizers as well as application of light and tissue oxygenation might pave the way for more effective PDT approaches. Furthermore, novel promising approaches to improve outcome in PDT such as selectivity, bioengineering, subcellular/organelle targeting, etc. will also be discussed in detail, since the potential of pioneering and exceptional approaches that aim to overcome the limitations and reveal the full potential of PDT in terms of clinical translation are undoubtedly exciting. A better understanding of novel concepts in the field (e.g. enhanced, two-stage, fractional PDT) will most likely prove to be very useful for pursuing and improving effective PDT strategies.

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Section: Mechanisms Of Actionmentioning

confidence: 99%

Section: Mechanisms Of Actionmentioning

confidence: 99%

Photodynamic Therapy—Current Limitations and Novel Approaches

2021

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“…Currently, the role of the third mechanism, based on local overheating (hyperthermia) of different cell compartments due to photo absorption, is discussed. This mechanism has become dominated in the case of different types of nanoparticles used for PDI (Yoo et al 2021 ). The development of bacterial resistance to PDI is believed to be unlikely due to the non-specific damage caused by ROS, 1 O 2 or local overheating (Maisch 2007 ; Bruce-Micah et al 2009 ).…”

Section: Photodynamic Inactivation Of Bacteria—general Aspectsmentioning

confidence: 99%

Photoinactivation of mycobacteria to combat infection diseases: current state and perspectives

Shleeva

Savitsky

Kaprelyants

2021

Appl Microbiol Biotechnol

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The spread of multi-drug-resistant bacterial strains causing serious infectious diseases dictates the development of new approaches to combat these diseases. In addition to drug resistance, the important causative agent of tuberculosis (Mycobacterium tuberculosis (Mtb)) is able to persist asymptomatically in individuals for many years, causing latent forms of tuberculosis. In such a dormant state, Mtb cells are also resistant to known antibiotics. In this regard, photodynamic inactivation (PDI) could be an effective alternative to antibiotics as its action is based on the generation of active forms of oxygen independently on the presence of specific antibiotic targets, thereby inactivating both drug-resistant and dormant bacteria. In this review, we summarise examples of the application of PDI for the elimination of representatives of the genus Mycobacteria, both in vitro and in vivo. According to published results, including photosensitisers in the PDI regime results in a significantly higher lethal effect. Such experiments were mainly performed using chemically synthesised photosensitisers, which need to be transported to the areas of bacterial infections, limiting PDI usage by surface (skin) diseases. In this regard, endogenous photosensitisers (mainly porphyrins) could be used to solve the problem of transportation. In vitro experiments demonstrate the effective application of PDI for mycobacteria, including Mtb, using endogenous porphyrins; the intracellular contents of these substances can be elevated by administration of 5-aminolevulenic acid, a precursor of porphyrin synthesis. Photodynamic inactivation can also be used for dormant mycobacteria, which are characterised by high levels of endogenous porphyrins. Thus, PDI can effectively eliminate drug-resistant mycobacteria. The exploitation of modern light-transmitting techniques opens new possibilities to use PDI in clinical settings. Key points•The potential effects of photodynamic inactivation of mycobacteria are critically reviewed.•Approaches to photoinactivation of mycobacteria using exogenous and endogenous photosensitisers are described.•Prospects for the use of photodynamic inactivation in the treatment of tuberculosis are discussed.

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“…Currently, it is supposed that although plaque macrocalcifications (as in fibrocalcific plaque) increase plaque stability, microcalcifications tend to destabilize the plaque [144]. Some clinical trials using the abovementioned methods in the therapy of atherosclerotic plaque have already been undertaken [139]. For instance, the NANOM-FIM trial has demonstrated that a group of patients who received silica-gold nanoparticles with subsequent PPTT presented a significantly higher probability of event-free survival than the control group (91.7% vs. 80%) who only received a drug-eluting stent [140].…”

Section: Alternative Approachesmentioning

confidence: 99%

Different Approaches in Therapy Aiming to Stabilize an Unstable Atherosclerotic Plaque

Kowara

Cudnoch‐Jędrzejewska

2021

IJMS

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Atherosclerotic plaque vulnerability is a vital clinical problem as vulnerable plaques tend to rupture, which results in atherosclerosis complications—myocardial infarctions and subsequent cardiovascular deaths. Therefore, methods aiming to stabilize such plaques are in great demand. In this brief review, the idea of atherosclerotic plaque stabilization and five main approaches—towards the regulation of metabolism, macrophages and cellular death, inflammation, reactive oxygen species, and extracellular matrix remodeling have been presented. Moreover, apart from classical approaches (targeted at the general mechanisms of plaque destabilization), there are also alternative approaches targeted either at certain plaques which have just become vulnerable or targeted at the minimization of the consequences of atherosclerotic plaque erosion or rupture. These alternative approaches have also been briefly mentioned in this review.

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Non-Oncologic Applications of Nanomedicine-Based Phototherapy

Cited by 38 publications

References 213 publications

Photodynamic Therapy—Current Limitations and Novel Approaches

Photodynamic Therapy—Current Limitations and Novel Approaches

Photoinactivation of mycobacteria to combat infection diseases: current state and perspectives

Different Approaches in Therapy Aiming to Stabilize an Unstable Atherosclerotic Plaque

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