Non-operative management of osteoarthritis of the knee joint

Vaishya, Raju; Pariyo, Godfrey B.; Agarwal, Amit Kumar; Vijay, Vipul

doi:10.1016/j.jcot.2016.05.005

Cited by 79 publications

(71 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Platelet-rich plasma is under consideration as an innovative and promising tool with an effectiveness pattern comparable to the intra-articular administration of hyaluronic acid (7). Stem cell therapy is an additional strategy whose aim is to support the process of self-healing of the knee joint cartilage damage resulting from OA symptoms (1). The intra-articular application of stem cells, facilitating their differentiation into chondrocytes, is a process that includes the separation of the cells by centrifugation and other purification steps, with the aim of increasing cartilage buildup.…”

Section: Discussionmentioning

confidence: 99%

“…Osteoarthritis (OA) is a chronic disorder of synovial joints, in which there is progressive softening and disintegration of articular cartilage accompanied by other alterations, including osteophyte growth, cyst formation and subchondral sclerosis (1). It is the most common form of arthritis, and is the primary cause of disability and impaired quality of life in the elderly (2).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A promising novel formulation for articular cartilage regeneration: Preclinical evaluation of a treatment that produces SOX9 overexpression in human synovial fluid cells

Delgado‐Enciso

García²,

Hernández

et al. 2017

Mol Med Report

View full text Add to dashboard Cite

Osteoarthritis (OA) is a chronic disorder of synovial joints, in which there is progressive softening and disintegration of the articular cartilage. OA is the most common form of arthritis, and is the primary cause of disability and impaired quality of life in the elderly. Despite considerable medical necessity, no treatment has yet been proven to act as a disease-modifying agent that may halt or reverse the structural progression of OA. The replacement of the joint with a prosthesis appears to be the best option in the advanced stages of the disease. A formulation (BIOF2) for cartilage regeneration has been recently developed. The present study evaluated the effects of BIOF2 on gene expression in human cell cultures, followed by efficacy trials in three OA animal models. Human synovial fluid cells that were exposed to the formulation exhibited increased transcription factor SOX-9 (SOX9; chondrogenic factor) expression, and decreased mimecan (mineralization inducer) and macrophage-stimulating protein receptor (osteoclastogenic factor) expression. The intra-articular application of BIOF2 in the animal models significantly increased cartilage thickness from 12 to 31% at 28 days, compared with articular cartilage treated with saline solution. The articular area and number of chondrocytes additionally increased significantly, maintaining an unaltered chondrocyte/mm2 proportion. Evaluation of the histological architecture additionally displayed a decrease in the grade of articular damage in the groups treated with BIOF2. In conclusion, BIOF2 has proven to be effective for treating OA in animal models, most likely due to SOX9 overexpression in articular cells.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A promising novel formulation for articular cartilage regeneration: Preclinical evaluation of a treatment that produces SOX9 overexpression in human synovial fluid cells

Delgado‐Enciso

García²,

Hernández

et al. 2017

Mol Med Report

View full text Add to dashboard Cite

show abstract

“…It has a variety of functions within joints such as shock absorption, energy dissipation, lubrication [20] and despite primarily being a structural protein it has also been shown to exert an anti-inflammatory effect [21]. Knees with OA have been shown to be deficient in hyaluronic acid (HA) which is a vital component of the synovial fluid and involved in lubricating all synovial joints [22]. McAlindon et al also note that introduction of exogenous HA also leads to increased endogenous HA production and the effects continue far beyond the duration of the exogenous administration [23].…”

Section: Viscosupplementationmentioning

confidence: 99%

Intra-articular Injections for Management of Knee Osteoarthritis

Golding¹,

Brock²,

Whiting³

et al. 2017

J Arthritis

View full text Add to dashboard Cite

Knee pain is an increasingly common presentation to general practitioners worldwide which is thought to be related to the obesity epidemic, an ageing population and increasingly sedentary lifestyles in more developed nations. Degenerative osteoarthritis (OA) accounts for the majority of presentations in older age groups and this has traditionally been treated with analgesia, lifestyle modifications and adjuncts such as physiotherapy, braces and insoles. All these therapies aim to delay the need of total knee replacement (TKR), which is often the end-point for severe knee OA. However, TKR is associated with poor levels of patient satisfaction, low functional outcomes and has recently been shown to have low levels of cost-effectiveness except in patients with severe disabling OA. Increasingly doctors are turning to intra-articular injections which can provide temporary pain relief such as corticosteroids, hyaluronic acid and platelet rich plasma. This article aims to review the current options for intraarticular injections, comment on their efficacy and suggest areas for future development.

show abstract

“…After considering the risks and benefits of a total knee replacement (TKR), the patient opted for non-operative management of his knee osteoarthritis. A standard non-operative management protocol was followed [1]. This included non-steroidal anti-inflammatory drugs, physiotherapy and intra-articular injections of local anaesthetic and steroid.…”

Section: Introductionmentioning

confidence: 99%

Pseudoaneurysm of the Superficial Femoral Artery after Knee Arthroscopy

Carroll

Fulton

Reidy

2020

Cureus

View full text Add to dashboard Cite

An 84 year old gentleman underwent knee arthroscopy. He had x-ray proven left knee osteoarthritis. He had a number of medical co-morbidities including being on an anticoagulant for atrial fibrillation. He did not want a knee replacement. A knee arthroscopy was performed which confirmed severe left knee osteoarthritis. Debridement of degenerative meniscus was performed. Three weeks post-operatively, the patient presented to the emergency department complaining of swelling and pain in his lower limb. He underwent an ultrasound venogram to look for a deep venous thrombosis (DVT). He was diagnosed with a pseudoaneurysm (PSA) of the superficial femoral artery (SFA). Subsequently, he was referred to the vascular surgery service who treated the PSA with covered stenting. The thigh and knee pain dissipated almost immediately. We propose that this is the first PSA of the left SFA to be documented after a knee arthroscopy. The authors would like to acknowledge that knee arthroscopy for severe osteoarthritis is rarely performed in an octogenarian. However, as this patient had declined a total knee replacement (TKR) and injections were no longer providing him relief, knee arthroscopy was performed.

show abstract

Non-operative management of osteoarthritis of the knee joint

Cited by 79 publications

References 19 publications

A promising novel formulation for articular cartilage regeneration: Preclinical evaluation of a treatment that produces SOX9 overexpression in human synovial fluid cells

A promising novel formulation for articular cartilage regeneration: Preclinical evaluation of a treatment that produces SOX9 overexpression in human synovial fluid cells

Intra-articular Injections for Management of Knee Osteoarthritis

Pseudoaneurysm of the Superficial Femoral Artery after Knee Arthroscopy

Contact Info

Product

Resources

About