Non-ossifying fibroma (metaphyseal fibrous defect) of the mandible

Albanese, Ana Luiza; Freire-Maia, Belini; Nunes, Fernanda Cardoso Fonseca; Souza, Paulo Eduardo Alencar; Gomez, Ricardo Santiago

doi:10.1007/s10006-010-0244-7

Cited by 11 publications

(24 citation statements)

References 16 publications

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“…Jaw lesions of the NOF may be asymptomatic [4,10,[16][17][18][19][20] or may present with expansion [5,12,21,22]. The radiographic appearance as a well-demarcated multilocular radiolucency with sclerotic borders in the current case and in the majority of other cases reported in the mandible [16,18,19,21] is similar to the typical radiographic appearance in the long bones [7,20].…”

Section: Discussionmentioning

confidence: 59%

“…While in the long bones, lesions greater than 3 cm are given the designation as NOFs, the same cannot be said of gnathic lesions. Some authors have dually designated the lesions as ''fibrous cortical defect (non-ossifying fibroma)'' or ''non-ossifying fibroma (metaphyseal fibrous defect)'' [5].…”

Section: Discussionmentioning

confidence: 99%

“…In other cases of mandibular NOF, giant cells have been reported to be scattered throughout the lesion. [5,10,19,24]. The foam or xanthoma cells are often a distinctive feature of the NOF and are thought to represent secondary, regressive changes rather than neoplasia [7,16,20,26,27].…”

Section: Discussionmentioning

confidence: 99%

“…All reported cases of NOF of the mandible have been successfully treated by curettage or resection with no reports of recurrence. Radiotherapy is not indicated [5,16]. One case in the mandibular condyle reported by Hudson et al, was identified intraoperatively by frozen section (and later confirmed by routine microscopy) and was treated using endoscopic visualization and aggressive curettage without disruption of the condylar head followed by intracapsular matrix augmentation using freeze-dried collagen.…”

Section: Discussionmentioning

confidence: 99%

“…A number of synonyms for the NOF have been used which are descriptive and reflect the natural evolution of the lesion. These names include histiocytic fibrous defect, metaphyseal fibrous defect, fibrous cortical defect [5], fibrous xanthoma and histiocytic xanthogranuloma [6].…”

Section: Introductionmentioning

confidence: 99%

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The Non-ossifying Fibroma: A Case Report and Review of the Literature

Bowers

Cohen

Bhattacharyya

et al. 2012

Head and Neck Pathol

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The non-ossifying fibroma (NOF) is a benign, non-neoplastic lesion most commonly seen in the metaphyses of the long bones in children. While rare, the NOF has been reported in the mandible. The NOF in the extra-gnathic skeleton has a characteristic radiographic appearance, is typically asymptomatic and has a variable histologic make-up. Correlation of the radiographic appearance, clinical presentation and histopathology allows for differentiation of the NOF from odontogenic and nonodontogenic cysts and tumors. We report a new case of this interesting entity and review the radiographic, clinical and histologic features of the gnathic NOF reported in the literature. A thorough search of the English language literature returned a total of 19 cases of NOF involving the gnathic bones.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The Non-ossifying Fibroma: A Case Report and Review of the Literature

Bowers

Cohen

Bhattacharyya

et al. 2012

Head and Neck Pathol

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Literature Review, Case Presentation and Management of Non-ossifying Fibroma of Right Angle of Mandible: More Than just a Cortical Defect!

Pandiar,

Anbumani,

Krishnan

2023

Indian J Otolaryngol Head Neck Surg

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Primary Intraosseous Xanthomas of the Jaws: A Series of Six Cases Including an Example with Formation of Apoptosis-Related Hyaline Globules, So-Called “Thanatosomes”

Wilkinson

Merkourea

Gopalakrishnan

et al. 2020

Head and Neck Pathol

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Primary intraosseous xanthomas of the jaws (PIXJ) are rare and predominantly affect the posterior mandible (86%) of normolipemic patients, with a mean age of 30 years and no gender predilection. Clinically, PIXJ exhibit indolent biologic behavior; curettage is considered treatment of choice. Only 36 PIXJ have been reported. Apoptosis-related hyaline globules (HGs), also known as "thanatosomes", have not been previously reported in PIXJ. Cases diagnosed as xanthoma of bone were retrieved. Six cases fulfilling currently accepted criteria were identified and their clinicopathologic and immunohistochemical properties are presented herein. Mean age for PIXJ was 21.8 years (range = 12-33) and F:M ratio = 2:1. All cases presented as well-demarcated, unilocular or multilocular radiolucencies. Microscopically, PIXJ featured sheets of lipid-laden macrophages with eosinophilic or foamy cytoplasm. A secondary fibroblastic population lacking storiform pattern was evident in two cases. Adipocytes (3/6), peripheral neurovascular bundles (1/6), bone fragments (3/6) and dystrophic calcifications (3/6) were observed enclosed by the xanthoma cells. Notably, one case exhibited numerous, spherical, eosinophilic HGs containing apoptotic nuclei. PIXJ were consistently CD68(+) and negative for CD1α and S100. CD45 decorated lymphocytes and the membrane of foamy histiocytes. Xanthoma cells stained for lysozyme and plasma proteins including alpha-1 antitrypsin (AAT), IgG and IgA in one probed case. HGs were lysozyme(+), AAT(+), IgG(+), IgA(+), PAS(+) and diastase-resistant, and fuchsinophilic with Masson's trichrome. PIXJ represent infrequent, solitary, mandibular lesions with a predilection for the second and third decade of life. Thanatosomes associated with cell injury and death can be present in PIXJ.

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Non-ossifying fibroma (metaphyseal fibrous defect) of the mandible

Cited by 11 publications

References 16 publications

The Non-ossifying Fibroma: A Case Report and Review of the Literature

The Non-ossifying Fibroma: A Case Report and Review of the Literature

Literature Review, Case Presentation and Management of Non-ossifying Fibroma of Right Angle of Mandible: More Than just a Cortical Defect!

Primary Intraosseous Xanthomas of the Jaws: A Series of Six Cases Including an Example with Formation of Apoptosis-Related Hyaline Globules, So-Called “Thanatosomes”

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