Non-oxidative effects of the flavonoid-rich fraction of <i>Lasianthera africana</i> leaves on human haemoglobin

Anorue, Eleazar Chukwuemeka; Ekpo, Daniel Emmanuel

doi:10.1080/26895293.2020.1846085

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…Mineral assessment of LA leaves revealed that it contains a considerable amount of magnesium, potassium, calcium, phosphorus, iron, and vitamins A, B 1 , and C; the leaves were also reported to contains glycoside, saponin, carotenoids, oxalate, and polyphenols in the same study (Wekhe et al, 2022 ). Recently, Anorue and Ekpo ( 2020 ) reported the nonoxidative effect of LA extracts on human hemoglobin.…”

Section: Introductionmentioning

confidence: 99%

African Jointfir (Gnetum africanum) and Editan (Lasianthera africana) leaf alkaloid extracts exert antioxidant and anticholinesterase activities in fruit fly (Drosophila melanogaster)

Oboh

Atoki

Ademiluyi

et al. 2023

Food Science & Nutrition

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African Jointfir (Gnetum africanum) and Editan (Lasianthera africana) leaves are two leafy green veggies with several nutritional and medicinal properties. Alzheimer's disease (AD) is a form of neurodegeneration that is believed to cause dementia in affected individuals. The quest for alternative treatments has necessitated the exploitation of plants' secondary metabolites. Plant alkaloids have recently demonstrated relevance in the management of a variety of neurodegenerative disorders; although there is limited information on the neuroprotective properties of alkaloids from various tropical green leafy vegetables with neuroprotective potentials. As a result, this study examined the cholinesterase inhibitory activity and antioxidant potential of alkaloid extracts from the leaves of African Jointfir (G. africanum) and Editan (L. africana). Standard solvent extraction techniques were used to prepare alkaloid extracts. After that, these extracts were characterized using high‐performance liquid chromatography. In vitro acetylcholinesterase inhibition assay for the extracts was also carried out. Subsequently, the alkaloid extracts were included in the diets of these flies (2 and 10 μg/g) for 7 days. Thereafter, treated fly homogenates were assayed for cholinesterase, monoamine oxidase, and antioxidant enzymes (specifically, glutathione‐S‐transferase catalase, and superoxide dismutase) activities, in addition, thiobarbituric acid reactive substance, reactive oxygen species, and total thiol contents. The extracts showed considerable anticholinesterase, antioxidant, and antimonoamine oxidase capabilities, according to the study's findings. Also, HPLC characterization revealed that desulphosinigrin (597,000 ng/100 g) and atropine (44,200 ng/100 g) are the predominating phytochemicals in Editan and African Jointfir respectively. These extracts could serve as potential sources of nutraceuticals with neuroprotective properties which can be used in the treatment/management of Alzheimer's disease.

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Section: Introductionmentioning

confidence: 99%

African Jointfir (Gnetum africanum) and Editan (Lasianthera africana) leaf alkaloid extracts exert antioxidant and anticholinesterase activities in fruit fly (Drosophila melanogaster)

Oboh

Atoki

Ademiluyi

et al. 2023

Food Science & Nutrition

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“…Flavonoids are a class of low molecular weight phenolic compounds, widely distributed in plants. They possess variable phenolic structures, and are widely distributed in fruits, vegetables, grains, bark, roots, stems, flowers, tea and wine (Anorue et al, 2020). One of the unique features of flavonoids which makes them pharmacologically active is their antioxidative property (Anorue et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…They possess variable phenolic structures, and are widely distributed in fruits, vegetables, grains, bark, roots, stems, flowers, tea and wine (Anorue et al, 2020). One of the unique features of flavonoids which makes them pharmacologically active is their antioxidative property (Anorue et al, 2020). Anorue & Ekpo further stated that "Unlike other phytochemicals which are shown to undergo oxidation with the human haemoglobin when ingested either as food or drug, flavonoids have been reported to be safe for human consumption without undergoing any oxidative reactions with the human haemoglobin".…”

Section: Introductionmentioning

confidence: 99%

Effect of Flavonoid Rich Fraction of Coriandrum sativum Leaf on Lipid Profile, Nitric Oxide, Ang II and Cardio Histopathology in L-NAME Intoxicated Experimental Rats

Unegbu¹,

Onuoha²,

Ajah³

et al. 2022

Scholars Bulletin

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Coriandrum sativum has been used in traditional medicines as an anti-inflammatory, analgesic, and antibacterial agent. It is recently been shown to have antioxidant activities. This study evaluated the effects of Flavonoid Rich Fraction of Coriandrum sativum Leaf (FRFCSL) on Lipid Profile, Nitric Oxide, Ang II and Cardio Histopathology in L-NAME intoxicated Experimental Rats. Standard analytical method and DPPH radical scavenging activity were employed for the phytochemicals and antioxidant analysis respectively. The acute toxicity study showed the extract and flavonoids fraction are nontoxic at 5000mg/kg body weight. Thirty rats were divided into five groups of six (6) rats each. Group 1 was administered water and feed only, Group 2 was administered 40mg/kg N-Nitro-L-Arginine Methyl Ester (L-NAME) without treatment, Group 3 through 5 were administered 40mg/kg N-Nitro-L-Arginine Methyl Ester (L-NAME) with concomitant administration of Captopril (20mg/kg b.w), FRFCSL (200mg/kg b.w) and FRFCSL (400mg/kg b.w) respectively for 21 days. In phytochemical screening, presence of flavonoids, saponins, tannins, alkaloids, cardiac glycosides, steroids were confirmed as part of secondary metabolites in the extract. The flavonoid fraction showed increase % DPPH radical inhibition in concentration-dependent manner. FRFCSL treatment significantly (p<0.05) and dose-dependently lowered low density lipoprotein and triglycerides. Also It significantly (p<0.05) prevented L-NAME induced decrease in serum angiotensin II, high density lipoprotein and serum nitric oxide concentrations compared to the untreated rats. The Flavonoid Rich Fraction of Coriandrum Sativum Leaf showed great potential as antihypertensive, antihyperlipidemic and cardioprotective agent in rats thus confirming its usefulness in traditional health therapy and potential for antihypertensive drug development.

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Safety assessment and antimalarial property of methanol extract of Fagara zanthoxyloides root-bark on Plasmodium berghei-infected mice

et al. 2021

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Non-oxidative effects of the flavonoid-rich fraction of Lasianthera africana leaves on human haemoglobin

Cited by 5 publications

References 23 publications

African Jointfir (Gnetum africanum) and Editan (Lasianthera africana) leaf alkaloid extracts exert antioxidant and anticholinesterase activities in fruit fly (Drosophila melanogaster)

African Jointfir (Gnetum africanum) and Editan (Lasianthera africana) leaf alkaloid extracts exert antioxidant and anticholinesterase activities in fruit fly (Drosophila melanogaster)

Effect of Flavonoid Rich Fraction of Coriandrum sativum Leaf on Lipid Profile, Nitric Oxide, Ang II and Cardio Histopathology in L-NAME Intoxicated Experimental Rats

Safety assessment and antimalarial property of methanol extract of Fagara zanthoxyloides root-bark on Plasmodium berghei-infected mice

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