Non-palpable incidentally found testicular tumors: Differentiation between benign, malignant, and burned-out tumors using dynamic contrast-enhanced MRI

Sanharawi, Imane El; Corréas, Jean-Michel; Glas, L.; Ferlicot, Sophie; Izard, V.; Ducot, B.; Bellin, Marie‐France; Galand, Benoît; Rocher, Laurence

doi:10.1016/j.ejrad.2016.09.021

Cited by 27 publications

(28 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In adults, LCTs may be discovered because of gynecomastia, but are mostly depicted an incidental finding during US infertility screening. Dynamic enhanced MRI were more likely to show faster, higher and stronger enhancement compared to normal testis or seminomatous germ cell tumors [ 10 ], similar as our pediatric case.…”

Section: Discussionsupporting

confidence: 56%

“…Testicular adrenal rests tumors (TART) described in congenital adrenal hyperplasia is the main differential diagnosis in case of PP associated with testicular mass. TARTs may be hypoechoic or hyperechoic at US, mainly located near the mediastinum and bilateral, and showing a multilocular pattern, and those signs helped to differentiate them from LCTs [ 10 ]. Their vascularization may vary, described as intense [ 10 ] or poor [ 11 ] as reported in recent case series.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Precocious puberty related to Leydig cell testicular tumor: the diagnostic imaging keys

et al. 2022

Self Cite

View full text Add to dashboard Cite

Background We report the challenging case of a 6-year-old boy with precocious puberty related to histologically proven Leydig cell tumor. Case presentation Multiparametric ultrasound and magnetic resonance imaging (MRI) was performed. Interesting findings were scarcely or never reported in children and differed from adults Leydig cell tumors s such as the hyperechogenic halo surrounding the lesion and the dominant central vascularization using ultrasensitive Doppler. MRI revealed an enlarged testicle with strong enhancement of a tumor, a tumor apparent diffusion coefficient (ADC) of 600 × 10−3 mm2/s and a lower ADC value of the non-tumor parenchyma compared to the contralateral testis (ADC = 800 × 10−3 mm2/s vs 1100 × 10−3 mm2/s), attributed to the spermatogenesis induced by hormonal impregnation. Conclusion We illustrate multiparametric US and MRI findings of a pediatric Leydig cell tumor, including the imaging changes attributed to local hormone secretion, which may be helpful in similar cases.

show abstract

Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Precocious puberty related to Leydig cell testicular tumor: the diagnostic imaging keys

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…The characteristics of testicular tumour regression are not specific, as there have been findings of hyperechogenic, hypoechogenic and mixed lesions, nodular and linear areas, signs of testicular atrophy and/or acoustic shadowing reflecting calcifications or fibrosis [3, 26, 59, 60]. If the ultrasound results are inconclusive, scrotal magnetic resonance imaging (sMRI) can be useful in better defining these findings that are not necessarily malignant (infarction, ischemia, trauma or infection) [43, 59, 61]. Patel and Patel [53] reported that, when using the sMRI, a finding that suggests neoplasia is the appearance of a rapid higher height peak at the lesion.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous testicular tumor regression: case report and historical review

Astigueta

Abad-Licham

Agreda³

et al. 2018

ecancer

View full text Add to dashboard Cite

Spontaneous regression of a primary testicular germ-cell tumour (GCT), over time known as ‘Burned out’, ‘Shrinking Seminoma’, ‘pT0’, ‘Burnout’ or ‘Spontaneous Regression’, is an uncommon, generally metastatic phenomenon, which may present elevated tumour markers and a suspicious testicular ultrasound image. The histological study of the testicle demonstrated morphological changes of complete or partial tumour regression and found fibrous scarring and other characteristic changes of this phenomenon, which in some cases include vestiges of GCT.There are few publications on testicular GCT tumour regression and those that exist present limited data on the biology of the disease and its etiopathogenesis. This entity was recently recognised in the latest edition of the World Health Organization’s (WHO) Classification of Tumours.We present our clinical, imaging, laboratory, cytohistological and management experience, as well as a historical review of the literature.

show abstract

“…Such findings, however, are nonspecific, because also non-neoplastic lesions, such as hematomas or infarctions, may present with a similar sonographic pattern (28). One study by El Sanharawi et al recently analyzed the vascularization of burned-out testicular tumor by dynamic contrast-enhanced magnetic resonance, demonstrating poor or absent enhancement in burned-out tumors (29), which is consistent with the typical histological appearance of fibrous scar and peripheral atrophy (8,10).…”

Section: Discussionmentioning

confidence: 89%

Burned-Out Testicular Tumors in Adolescents: Clinical Aspects and Outcome

et al. 2021

View full text Add to dashboard Cite

Purpose: Testicular germ cell tumors are the fourth most common neoplasm in adolescents, accounting for 8% of all tumors in the age group 15–19 years. On rare instances, the primary testicular lesion is not clinically or radiologically evident while nodal or visceral metastases represent the clinical manifestations of the disease. This phenomenon is described as “burned-out testicular tumor.” In this paper, the authors report a single-institution experience with burned-out testicular tumors in adolescents and discuss their clinical implications.Patients and Methods: All the patients diagnosed with metastatic testicular germ cell tumors at Bambino Gesù Children Hospital between January 1, 2010, and June 30, 2020, were included in the study. Patients were categorized into two groups: “primary testicular” and “burned out.” All the patients were staged and treated according to the AIEOP–TCGM 2004 protocol.Results: Eleven patients were classified as “primary testicular,” and five patients were classified as “burned out.” “Burned-out” tumors were associated with the presence of systemic symptoms compared to “primary testicular” tumors (80 vs. 0%; p = 0.0027) and higher aFP, hCG, and LDH levels (p < 0.00001). The “burned-out” population had a statistically significant higher incidence of relevant toxicity than the “primary testicular” population (80 vs. 18%; p = 0.0357) and a worse outcome in terms of both mean overall survival (15 vs. 43 months; p = 0.0299) and mean event-free survival (12 vs. 38 months; p = 0.0164).Conclusion: “Burned-out” testicular tumors seem to be a well-distinct clinical entity with a high treatment-related toxicity and poor prognosis. Further studies are needed to clarify the “burned-out phenomenon” and to identify more effective therapeutic strategies for these patients.

show abstract

Non-palpable incidentally found testicular tumors: Differentiation between benign, malignant, and burned-out tumors using dynamic contrast-enhanced MRI

Cited by 27 publications

References 32 publications

Precocious puberty related to Leydig cell testicular tumor: the diagnostic imaging keys

Precocious puberty related to Leydig cell testicular tumor: the diagnostic imaging keys

Spontaneous testicular tumor regression: case report and historical review

Burned-Out Testicular Tumors in Adolescents: Clinical Aspects and Outcome

Contact Info

Product

Resources

About