CHANGE-POINT ESTIMATION USING SHAPE-RESTRICTED REGRESSION SPLINESChange-Point estimation is in need in fields like climate change, signal processing, economics, dose-response analysis etc, but it has not yet been fully discussed. We consider estimating a regression function f m and a change-point m, where m is a mode, an inflection point, or a jump point. Linear inequality constraints are used with spline regression functions to estimate m and f m simultaneously using profile methods. For a given m, the maximum-likelihood estimate of f m is found using constrained regression methods, then the set of possible change-points is searched to find them that maximizes the likelihood. Finally, we consider the change-point estimation with generalized linear models. Such work can be applied to dose-response analysis, when the effect of a drug increases as the dose increases to a saturation point, after which the effect starts decreasing.iii Tanz . iv
DEDICATION
To the cutest, Francis, Nilus and