Non-pertussis Components of Combination Vaccines: Problems with Potency Testing

Effects of Simultaneous Immunization of Haemophilus influenzae Type b Conjugate Vaccine and Diphtheria-Tetanus-Acellular Pertussis Vaccine on Anti-Tetanus Potencies in Mice, Guinea Pigs, and Rats

“…This may corroborate the present observation that mice exhibited greater enhancement than guinea pigs and rats. Such species-dependent differences in interference are also reported with multi-component vaccines (8). Elucidating the mechanisms underlying the stimulation of potency in animal experiments will contribute to the development of a suitable quality control system for HibT and DTaP-Hib vaccines, which will be introduced for human use in Japan in the near future.…”

“…However, the immunization in childhood with Hib and DTaP vaccines has been complicated. Thus, DTaP-Hib vaccine is used in many countries to simplify immunization and reduce vaccination costs (6)(7)(8). However, DTaP-Hib vaccine has not yet been introduced for use in Japan.…”

Innovative vaccine production technologies: The evolution and value of vaccine production technologies

“…There have been reports of a decrease in the immune response to HepB vaccination in people given a combined DTaP-HepB vaccine, and of a significantly reduced immune response to Haemophilus influenzae type b (Hib) and FHA in recipients of a combined DTwP-Hib (tetanus toxoid-conjugated PRP (polyribosylribitol phosphate)) vaccine. These decreased efficacies are believed to be due to immunological incompatibility between antigens, or between antigens and impurities of DT (Andre, 1999;Bae et al, 2003;Bae et al, 2002;Greenberg et al, 2000;Pines et al, 1999;Sesardic et al, 1999;Yoo et al, 2000).…”

Recombinant hepatitis B Vaccines – Disease Characterization and Vaccine Production

“…Furthermore, in a study comparing the antigenicity of seperate, simultaneous and combined HAV and HBV vaccines it was found that combined and simultaneous vaccination elicited significantly higher anti-HAV titers than single immunization, while markedly but not significantly higher anti-HBs titers were found only with simultaneous vaccination (Czeschinski et al 2000). Although immunological interference between components of a vaccine combination may possibly affect immunogenicity testing (Sesardic et al 1999), it is clear that HBV administered simultaneously or in combination with other childhood vaccines can, at the very least, lower the cost and complexity of vaccine administration programs.…”