Non-Pharmacological Approach to Diet and Exercise in Metabolic-Associated Fatty Liver Disease: Bridging the Gap between Research and Clinical Practice

Abstract

This review provides a practical and comprehensive overview of non-pharmacological interventions for metabolic-associated fatty liver disease (MASLD), focusing on dietary and exercise strategies. It highlights the effectiveness of coffee consumption, intermittent fasting, and Mediterranean and ketogenic diets in improving metabolic and liver health. The review emphasizes the importance of combining aerobic and resistance training as a critical approach to reducing liver fat and increasing insulin sensitivity. Additionally, it discusses the synergy between diet and exercise in enhancing liver parameters and the role of gut microbiota in MASLD. The paper underscores the need for a holistic, individualized approach, integrating diet, exercise, gut health, and patient motivation. It also highlights the long-term benefits and minimal risks of lifestyle interventions compared to the side effects of pharmacological and surgical options. The review calls for personalized treatment strategies, continuous patient education, and further research to optimize therapeutic outcomes in MASLD management.

Potential of Chlorogenic Acid in the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Animal Studies and Clinical Trials—A Narrative Review

“…Furthermore, the recommendation of complete abstinence from alcohol may leave a grey area for patients who consume alcohol in moderation and may suffer from both alcoholic and metabolic diseases. However, some individuals perceive the term ‘steatosis’ to have a negative connotation [ 5 , 6 ], so the three large associations dealing with liver diseases led to a Delphi process to create a new nomenclature. The chosen name to replace NAFLD is MASLD—metabolic dysfunction-associated steatotic liver disease [ 7 , 8 , 9 ].…”

Reassessing the Impact of Coffee Consumption on Liver Disease: Insights from a Large-Scale Cohort Study with IPTW Adjustment

“…MetALD, although less well-defined in the literature, is increasingly implicating a requirement for the specific management of the disease and future prospective studies for better defining its natural history [5]. As understanding of MASLD and MetALD evolves, there is a growing emphasis on identifying modifiable lifestyle factors, such as diet and physical activity, that can mitigate the diseases progression [6].…”