Non-pharmacological interventions for cognitive impairment due to systemic cancer treatment

Treanor, Charlene; McMenamin, Úna C.; O'Neill, Raymond; Cardwell, Christopher; Clarke, Mike; Cantwell, Marie; Donnelly, Michael

doi:10.1002/14651858.cd011325.pub2

Cited by 60 publications

(52 citation statements)

References 124 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pharmacotherapies modestly alleviate cognitive deficits [ 73 , 74 ]; however, possible side effects and interactions highlight a need to explore modifiable lifestyle factors. While cognitive behavioral training and physical activity convey functional improvements in cancer survivors [ 75 , 76 ], there are no published dietary strategies. Nevertheless, survivors seek dietary changes to improve symptoms and reduce cancer risk [ 77 ].…”

Section: Discussionmentioning

confidence: 99%

Low Serum Carotenoids Are Associated with Self-Reported Cognitive Dysfunction and Inflammatory Markers in Breast Cancer Survivors

Zuniga

Moran

2018

Nutrients

View full text Add to dashboard Cite

Background: Dietary carotenoids may exert anti-inflammatory activities to reduce inflammation-driven cognitive impairments during cancer and cancer treatment. Our objective was to explore if cognitive function in breast cancer survivors (BCS) differs by serum carotenoid concentrations, and if blood carotenoids concentrations are associated with reduced systemic inflammation. Methods: Objective cognitive function and perceived cognitive impairment of 29 BCS and 38 controls were assessed cross-sectionally with the National Institutes of Health Toolbox Cognition Battery and The Functional Assessment of Cancer Therapy-Cognitive Function Questionnaire, respectively. Serum carotenoid and inflammatory marker (sTNF-RII, IL-6, IL-1ra, CRP) concentrations were measured. Results: Low-carotenoid BCS had more cognitive complaints compared to the low-carotenoid controls (Mdiff = −43.0, p < 0.001) and high-carotenoid controls (Mdiff = −44.5, p < 0.001). However, the cognitive complaints of high-carotenoid BCS were intermediate to and not different than the low-carotenoid BCS, or low- or high-carotenoid controls. BCS performed similarly to controls on all objective cognitive measures. Multiple linear regression, controlling for age and body mass index (BMI), demonstrated an inverse association between serum carotenoid concentrations and pro-inflammatory sTNFR-II (β = 0.404, p = 0.005) and IL-6 concentrations (β = −0.35, p = 0.001), but not IL-1ra or CRP. Conclusions: Higher serum carotenoid concentrations may convey cognitive and anti-inflammatory benefits in BCS. Future research should identify dietary components and patterns that support cognitive health in cancer survivors.

show abstract

Section: Discussionmentioning

confidence: 99%

Low Serum Carotenoids Are Associated with Self-Reported Cognitive Dysfunction and Inflammatory Markers in Breast Cancer Survivors

Zuniga

Moran

2018

Nutrients

View full text Add to dashboard Cite

show abstract

“… 30 In particular, a recent Cochrane review indicated that cognitive training may be effective in improving patients' cognitive function, as well as their QOL. 31 Additionally, behavioural intervention strategies (increasing physical activity levels and fostering supportive social relationships) could be helpful in improving cognitive function among cancer survivors. 12 …”

Section: Discussionmentioning

confidence: 99%

Cervical cancer survivors’ perceived cognitive complaints and supportive care needs in mainland China: a qualitative study

et al. 2017

View full text Add to dashboard Cite

ObjectivesThis study explores Chinese cervical cancer survivors’ perceived cognitive complaints and relevant supportive care needs after primary cancer treatment.DesignThis study utilised a qualitative research design. A semi-structured interview was used to probe cervical cancer patients’ perceived cognitive complaints and supportive care needs.SettingThis study was conducted at a secondary cancer care centre located in South China.Participants31 women with cervical cancer after primary cancer treatment, aged 18–60 years, were purposively selected using non-random sampling procedures.Results31 cervical cancer survivors joined this study. Of these, 20 women (64.5%) reported cognitive complaints after cancer treatment. The most common complaint was loss of concentration (n=17, 85.0%). Perceived contributing factors to these cognitive complaints included chemotherapy (n=15, 75.0%) and ageing (n=8, 40.0%). These cognitive problems most commonly impacted daily living (n=20, 100%). Common supportive care needs included symptom management strategies (n=11, 55.0%) and counselling services (n=8, 40.0%).ConclusionThis study adds new insight into the growing body of research on cognitive complaints by cancer survivors, in particular Chinese cervical cancer survivors. Improved understanding of cognitive complaints could subsequently facilitate the development of relevant therapeutic interventions for prevention as well as the provision of supportive care services, such as educational and counselling services, to reduce cognitive impairment in women with cervical cancer.

show abstract

“…So far, only a limited number of potential interventions targeting cancer-related cognitive impairment have been studied [13]. The most promising interventions so far appear to be cognitive training and physical activity [13,14]. However, due to a lack of active control groups and the consideration of biological outcomes, it remains unclear to what extent these interventions are effective.…”

Section: Introductionmentioning

confidence: 99%

A mindfulness-based intervention for breast cancer patients with cognitive impairment after chemotherapy: study protocol of a three-group randomized controlled trial

Gucht

Melis

Ahmadoun

et al. 2020

Trials

View full text Add to dashboard Cite

Background: Mindfulness has been applied to improve cancer care by enhancing psychological well-being. However, little is known about its impact on cognitive impairment experienced by cancer patients after chemotherapy. Mindfulness may be relevant in tackling cognitive impairment by decreasing emotional distress and fatigue, by decreasing inflammation, and by strengthening functional brain connectivity. The aim of the present study protocol is to evaluate the efficacy and mechanisms of a mindfulness-based intervention to reduce cognitive impairment in breast cancer patients after chemotherapy. Methods/design: The present study is a three-arm, parallel-group, randomized controlled trial with assessments at baseline, 1 to 3 weeks after the intervention and at 3 months' follow-up. One hundred and twenty breast cancer patients who ended treatment a minimum of 6 months and a maximum of 5 years before, and who have cognitive complaints, will be enrolled. They will be randomized into one of the following three study arms: (1) a mindfulnessbased intervention group (n = 40), (2) an active control condition based on physical training (n = 40), or (3) a treatment as usual (TAU) control group (n = 40). Both the mindfulness-based intervention and the active control condition consist of four group sessions (3 h for the mindfulness condition and 2 h for the physical training) spread over 8 weeks. The primary outcomes will be cognitive symptoms as measured by the Cognitive Failure Questionnaire and changes in functional brain connectivity in the attention network. Secondary outcomes will be (1) levels of emotional distress, fatigue, mindfulness, quality of life; (2) neurocognitive tests; (3) structural and functional brain changes using MR imaging and (4) measures of inflammation.

show abstract

Non-pharmacological interventions for cognitive impairment due to systemic cancer treatment

Cited by 60 publications

References 124 publications

Low Serum Carotenoids Are Associated with Self-Reported Cognitive Dysfunction and Inflammatory Markers in Breast Cancer Survivors

Low Serum Carotenoids Are Associated with Self-Reported Cognitive Dysfunction and Inflammatory Markers in Breast Cancer Survivors

Cervical cancer survivors’ perceived cognitive complaints and supportive care needs in mainland China: a qualitative study

A mindfulness-based intervention for breast cancer patients with cognitive impairment after chemotherapy: study protocol of a three-group randomized controlled trial

Contact Info

Product

Resources

About