Non-phthalate plasticizers in German daycare centers and human biomonitoring of DINCH metabolites in children attending the centers (LUPE 3)

Fromme, Hermann; Schütze, André; Lahrz, T.; Kraft, Martin; Fembacher, Ludwig; Siewering, S.; Burkardt, R.; Dietrich, S.; Koch, Holger M.; Völkel, Wolfgang

doi:10.1016/j.ijheh.2015.08.002

Cited by 114 publications

(69 citation statements)

References 24 publications

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“…Use of certain household and personal care products can result in exposures to phthalates, parabens, phenols and pesticides among infants and young children (Dyk et al, 2011; Larsson et al, 2014; Lewis et al, 2013; Philippat et al, 2015; Sathyanarayana et al, 2008). Interestingly, the reported concentrations among different populations of children, regardless of sample size and location, are fairly uniform in developed countries (CDC, 2015; Frederiksen et al, 2014; Fromme et al, 2016; Health Canada, 2013; Stacy et al, 2016; Wolff et al, 2010) suggesting widespread and likely similar exposures and exposure sources among children to these chemicals. Therefore, in this sample of pre-school aged children, like in other populations of children before, the observed wide range of concentrations for methyl and propyl paraben, triclosan, benzophenone-3 and DCBA likely suggest that consumer and personal care products could have contributed to higher than average exposures to these chemicals or their precursors at least in some of these children.…”

Section: Discussionmentioning

confidence: 99%

Co-exposure to non-persistent organic chemicals among American pre-school aged children: A pilot study

Calafat

Valentín-Blasini

et al. 2017

International Journal of Hygiene and Environmental Health

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Background General population human biomonitoring programs such as the National Health and Nutrition Examination Survey (NHANES) in the United States suggest that chemical exposures are common. Exposures during childhood may affect health later in life, but biomonitoring data in NHANES among pre-school aged children are limited. Methods A convenience group of 122 3–5 year old American boys and girls were recruited in 2013 for a pilot study to assess the feasibility of collecting urine from young children and analyzing it for select chemical exposure biomarkers for future NHANES. Children were primarily Hispanic (64.8%); the remainder was divided between non-Hispanic black, and non-Hispanic white and “other.” We measured 52 urinary biomarkers: 13 phthalates and one non-phthalate plasticizer, five phenols and four parabens, 10 polycyclic aromatic hydrocarbons (PAHs), and 19 pesticides. For each biomarker, we calculated descriptive statistics. We also calculated the number of biomarkers detected within each child, and performed principal components analysis (PCA). Results NHANES staff obtained permission to attempt collection of 60 mL urine from 3 to 5 year olds who participated in the 2013 NHANES health examination; 83% of children successfully provided the target volume. We detected 24 individual biomarkers of pesticides, phenols and parabens, phthalates/non-phthalate plasticizers, and PAHs in 95–100% of children. The median number of biomarkers detected was 37: nine pesticides, five phenols and parabens, 13 phthalates and non-phthalate plasticizers, and 10 PAHs. Biomarkers concentrations appear to be similar to national estimates among 6–11 year old children from previous NHANES. PCA suggested high within-class correlations among biomarkers. Conclusions These young children successfully adhered to the collection protocol and produced enough urine for the quantification of environmental biomarkers currently being measured in NHANES participants 6 years of age and older. Using the same analytical methods employed for the analysis of samples collected from older NHANES participants, in this sample of pre-school aged children we detected multiple chemicals including plasticizers, combustion products, personal-care product chemicals, and pesticides. Starting with NHANES 2015–2016, the NHANES biomonitoring program will include urinary biomarkers for 3–5 year old children to provide exposure data to select chemicals at the national level among this age group.

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Section: Discussionmentioning

confidence: 99%

Co-exposure to non-persistent organic chemicals among American pre-school aged children: A pilot study

Calafat

Valentín-Blasini

et al. 2017

International Journal of Hygiene and Environmental Health

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“…However, MHiNCH was detected in 19.3% of urine samples from National Health and Nutrition Examination Survey (NHANES) 2011–2012 participants (CDC 2015) and in the urine of 98% of German business students during 2012 (Schutze et al 2014). Moreover, two recent publications showed that MHiNCH was also detected in pooled urine samples collected from a convenience group of Australians (Gomez Ramos et al 2016) and a group of 27–80 month old children in Germany (Fromme et al 2016). Therefore, taken together, these findings show that there is ongoing exposure to the non-phthalate plasticizer DINCH; due to its increased use in various products, higher exposure is expected in the future.…”

Section: Introductionmentioning

confidence: 99%

Urinary concentrations of cyclohexane-1,2-dicarboxylic acid monohydroxy isononyl ester, a metabolite of the non-phthalate plasticizer di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH), and markers of ovarian response among women attending a fertility center

Mínguez-Alarcón

Souter

Chiu

et al. 2016

Environmental Research

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Di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH), a non-phthalate plasticizer, was introduced commercially in 2002 as an alternative to ortho-phthalate esters because of its favorable toxicological profile. However, the potential health effects from DINCH exposure remain largely unknown. We explored the associations between urinary concentrations of metabolites of DINCH on markers of ovarian response among women undergoing in vitro fertilization (IVF) treatments. Between 2011 and 2015, 113 women enrolled a prospective cohort study at the Massachusetts General Hospital Fertility Center and provided up to two urine samples prior to oocyte retrieval. The urinary concentrations of two DINCH metabolites, cyclohexane-1,2-dicarboxylic acid monohydroxy isononyl ester (MHiNCH) and cyclohexane-1,2-dicarboxylic acid monocarboxyisooctyl ester (MCOCH), were quantified by isotope dilution tandem mass spectrometry. We used generalized linear mixed models to evaluate the association between urinary metabolite concentrations and markers of ovarian response, accounting for multiple IVF cycles per woman via random intercepts. On average, women with detectable urinary MHiNCH concentrations, as compared to those below LOD, had a lower estradiol levels (−325 pmol/l, p=0.09) and number of retrieved oocytes (−1.8, p=0.08), with a stronger association among older women. However, urinary MHiNCH concentrations were unrelated to mature oocyte yield and endometrial wall thickness. In conclusion, we found suggestive negative associations between urinary MHiNCH concentrations and peak estradiol levels and number of total oocyte yields. This is the first study evaluating the effect of DINCH exposure on human reproductive health and raises the need for further experimental and epidemiological studies to better understand the potential effects of this chemical on health.

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“…More than 20 phthalate replacements have been reported [3]. Three of the newer ones have been found in human biomonitoring (DINCH, DEHT, DEHA; figure 1) [3,7]. It is unclear whether the replacements are less toxic or less persistent.…”

Section: Resultsmentioning

confidence: 99%

Emerging exposures of developmental toxicants

Wolff

Buckley

Engel

et al. 2017

Current Opinion in Pediatrics

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Purpose The purpose of this review is to identify emerging developmental toxicants that are understudied in children’s health. Exposures may arise from new products designed to improve utility, to reduce toxicity, or to replace undesirable chemicals. Exposures to less toxic chemicals may also be significant if they are very commonly used, thereby generating widespread exposure. Sources of exposure include the workplace, personal, home and office products; food, water, and air. Recent Findings We describe eight exposure categories that contain numerous potential developmental toxicants. References are discussed if reported in PubMed during the past decade at least ten-times more frequently than in 1990–2000. Examples included phthalates, phenols, sunscreens, pesticides, halogenated flame retardants, perfluoroalkyl coatings, nanoparticles, e-cigarettes, and dietary polyphenols. Replacements are often close structural homologs of their precursors. We suggest biomonitoring as preferred means of exposure assessment to emerging chemicals. Some existing analytic methods would require minimal modification to measure these exposures, but others require toxicokinetic and analytic investigation. Summary A deliberate strategy for biomonitoring of emerging replacement chemicals is warranted, especially in view of concerns regarding developmental toxicity. To prevent adverse health effects, it is important to characterize such exposures before they become widely disseminated.

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Non-phthalate plasticizers in German daycare centers and human biomonitoring of DINCH metabolites in children attending the centers (LUPE 3)

Cited by 114 publications

References 24 publications

Co-exposure to non-persistent organic chemicals among American pre-school aged children: A pilot study

Co-exposure to non-persistent organic chemicals among American pre-school aged children: A pilot study

Urinary concentrations of cyclohexane-1,2-dicarboxylic acid monohydroxy isononyl ester, a metabolite of the non-phthalate plasticizer di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH), and markers of ovarian response among women attending a fertility center

Emerging exposures of developmental toxicants

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