Non-Random Genome Editing and Natural Cellular Engineering in Cognition-Based Evolution

Miller, William B.; Enguita, Francisco J.; Leitão, Ana Lúcia

doi:10.3390/cells10051125

Cited by 13 publications

(14 citation statements)

References 206 publications

(353 reference statements)

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“…A new, more general view of cognition that recognizes not only humans as cognitive agents but includes all living beings, casts a completely new light on the process of evolution. Evolution has been described as a cognition-based process driven by non-random genome editing and natural cellular engineering [ 44 ]. Torday and Miller elaborated on the view of cognition-based evolution in the context of epigenetic evolutionary biology [ 45 ].…”

Section: Cognition As a Driver Of Evolution And Evolution As A Driver...mentioning

confidence: 99%

“…”Cognition-Based Evolution argues that all of the biological and evolutionary development represents the perpetual auto-poietic defense of self-referential basal cellular states of homeostatic preference. The means by which these states are attained and maintained is through self-referential measurement of information and its communication” [ 44 ].…”

Section: Cognition As a Driver Of Evolution And Evolution As A Driver...mentioning

confidence: 99%

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Cognition as Morphological/Morphogenetic Embodied Computation In Vivo

Dodig-Crnković

2022

Entropy

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Cognition, historically considered uniquely human capacity, has been recently found to be the ability of all living organisms, from single cells and up. This study approaches cognition from an info-computational stance, in which structures in nature are seen as information, and processes (information dynamics) are seen as computation, from the perspective of a cognizing agent. Cognition is understood as a network of concurrent morphological/morphogenetic computations unfolding as a result of self-assembly, self-organization, and autopoiesis of physical, chemical, and biological agents. The present-day human-centric view of cognition still prevailing in major encyclopedias has a variety of open problems. This article considers recent research about morphological computation, morphogenesis, agency, basal cognition, extended evolutionary synthesis, free energy principle, cognition as Bayesian learning, active inference, and related topics, offering new theoretical and practical perspectives on problems inherent to the old computationalist cognitive models which were based on abstract symbol processing, and unaware of actual physical constraints and affordances of the embodiment of cognizing agents. A better understanding of cognition is centrally important for future artificial intelligence, robotics, medicine, and related fields.

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Section: Cognition As a Driver Of Evolution And Evolution As A Driver...mentioning

confidence: 99%

Section: Cognition As a Driver Of Evolution And Evolution As A Driver...mentioning

confidence: 99%

Cognition as Morphological/Morphogenetic Embodied Computation In Vivo

Dodig-Crnković

2022

Entropy

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“…These depictions contrast sharply with the extent to which they are often regulated (Capy et al 2000) and targeted (Sultana et al 2017) and with the benefits they can confer to host organisms. Such observations are forcing the use of increasingly design-based language . Miller Enguita & Leitão (2021) in a recent review article about TEs and other NGE processes commented:…”

Section: Natural Genetic Engineeringmentioning

confidence: 99%

Qualified agreement: How scientific discoveries support theistic belief

Meyer¹

2022

Reformed Theology in Africa Series

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Peer review declarationThe publisher (AOSIS) endorses the South African 'National Scholarly Book Publishers Forum Best Practice for Peer Review of Scholarly Books.' The manuscript underwent an evaluation to compare the level of originality with other published works and was subjected to rigorous two-step peer review before publication, with the identities of the reviewers not revealed to the editor(s) or author(s). The reviewers were independent of the publisher, editor(s), and author(s). The publisher shared feedback on the similarity report and the reviewers' inputs with the manuscript's editor(s) or author(s) to improve the manuscript. Where the reviewers recommended revision and improvements, the editor(s) or author(s) responded adequately to such recommendations. The reviewers commented positively on the scholarly merits of the manuscript and recommended that the book be published. v Research justificationScience and Faith in Dialogue presents a cogent, compelling case for concordance between science and theism. The term theism used in this book refers to the belief in God's existence. Within theology, the term theism is often used to convey a range of presuppositions about the nature and attributes of God. The topic of God's attributes does not fall within the scope of this study. Based on scientific and natural theological perspectives, two pillars of natural theology are revisited: the Cosmological Argument and the Argument from Design. The book argues that modern science provides undeniable evidence and a scientific basis for these classical arguments to infer a rationally justifiable endorsement of theism as being concordant with reason and science -nature is seen as operating orderly on comprehensible, rational, consistent laws, in line with the conviction that God is Creator. The expression 'undeniable evidence and scientific basis' is not understood as scientific proof but rather as inference, footprint, signature, deductive reasoning and rational justification for theism in world view. The premise that theism asserts a more causally adequate explanation of recent developments in modern natural science (than naturalism) is based upon: (1) Strong epistemological support: explanatory power and confirmation of hypothesis (rather than just deductive entailment); and (2) the contemporary cosmological consensus, building upon the rigour of the physical sciences and illuminating biological discoveries. The discovery that the universe had a beginning and the abundant scientific evidence for fine-tuning is best explained by theism. The phrase 'global fine-tuning' refers to fine-tuning of initial conditions, fundamental forces and other physical laws and constants for an expanding universe and the formation of galaxies, stars and planets. The phrase 'local fine-tuning' refers to the protection of the earth by the planetary giants, earth's life-sustaining capabilities, water and its miraculous properties for life, earth's rare habitability fine-tuned for life and scientific discovery. The phrase 'biological fin...

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“…Consequently, mutation can no longer be considered a directionless force in evolution. Instead, variations arise from epigenetic impacts that drive differential patterns of Natural Cellular Engineering through largely nonrandom genome editing, producing altered phenotypes [ 39 ]. Accordingly, the operative propulsive drive in evolution is collective cellular action to assimilate environmental challenges.…”

Section: Introductionmentioning

confidence: 99%

“…Further, the assumption that viral quasi-species generation results from random genetic variations is called into question. Instead, most virocellular interactions are transfers of nonrandom recombinant genetic modules that confer bioactive cellular expression as part of a universal biological process of Natural Cellular Engineering [ 39 ]. Reciprocally, cellular genetic material represents its own source of modular substitutions for recipient viruses as part of continuous virocellular exchanges.…”

Section: Introductionmentioning

confidence: 99%

Cellular and Natural Viral Engineering in Cognition-Based Evolution

Miller

Reber

Marshall³

et al. 2023

Communicative & Integrative Biology

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Neo-Darwinism conceptualizes evolution as the continuous succession of predominately random genetic variations disciplined by natural selection. In that frame, the primary interaction between cells and the virome is relegated to host-parasite dynamics governed by selective influences. Cognition-Based Evolution regards biological and evolutionary development as a reciprocating cognition-based informational interactome for the protection of self-referential cells. To sustain cellular homeorhesis, cognitive cells collaborate to assess the validity of ambiguous biological information. That collective interaction involves coordinate measurement, communication, and active deployment of resources as Natural Cellular Engineering. These coordinated activities drive multicellularity, biological development, and evolutionary change. The virome participates as the vital intercessory among the cellular domains to ensure their shared permanent perpetuation. The interactions between the virome and the cellular domains represent active virocellular cross-communications for the continual exchange of resources. Modular genetic transfers between viruses and cells carry bioactive potentials. Those exchanges are deployed as nonrandom flexible tools among the domains in their continuous confrontation with environmental stresses. This alternative framework fundamentally shifts our perspective on viral-cellular interactions, strengthening established principles of viral symbiogenesis. Pathogenesis can now be properly appraised as one expression of a range of outcomes between cells and viruses within a larger conceptual framework of Natural Viral Engineering as a co-engineering participant with cells. It is proposed that Natural Viral Engineering should be viewed as a co-existent facet of Natural Cellular Engineering within Cognition-Based Evolution.

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Non-Random Genome Editing and Natural Cellular Engineering in Cognition-Based Evolution

Cited by 13 publications

References 206 publications

Cognition as Morphological/Morphogenetic Embodied Computation In Vivo

Cognition as Morphological/Morphogenetic Embodied Computation In Vivo

Qualified agreement: How scientific discoveries support theistic belief

Cellular and Natural Viral Engineering in Cognition-Based Evolution

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