Non-receptor type, proline-rich protein tyrosine kinase 2 (Pyk2) is a possible therapeutic target for Kawasaki disease

Suzuki, Chinatsu; Nakamura, Akihiro; Miura, Noriko N.; Fukai, Kuniyoshi; Ohno, Naohito; Yahata, Tetsutaro; Okamoto-Hamaoka, Akiko; Fujii, Maiko; Yoshioka, Ayako; Kuchitsu, Yuki; Ikeda, Kazuyuki; Hamaoka, Kenji

doi:10.1016/j.clim.2017.01.013

Cited by 8 publications

(6 citation statements)

References 43 publications

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“…C57Bl/6 and BALB/c mice are the most frequently used inbred strains for immunological research and the establishment of gene knockout mice. [12][13][14][15] the presence of α-1,2-, α-1,3-, and α-1,6mannose links. [66][67][68] The spectral patterns shown in Figure 5 were similar to those in their studies and consistent with these findings.…”

Section: Biological and Pharmaceutical Bulletin Advance Publicationmentioning

confidence: 98%

Coronary Vasculitis Induced in Mice by the Cell Wall Mannoprotein of <i>Candida krusei</i>

Yanai

Tanaka

Miura

et al. 2020

Biological & Pharmaceutical Bulletin

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Kawasaki disease (KD) is an inflammatory disease that was identified by Professor Tomisaku Kawasaki in 1961. Candida albicans-derived substances, such as the hot water extract of C. albicans (CADS) and Candida water-soluble fraction (CAWS), induced coronary vasculitis similar to KD in mice. An increasing proportion of deep-seated candidiasis cases are caused by non-albicans Candida and are often resistant to antifungal drugs. We herein investigated whether the hot water extract of C. krusei, inherently resistant to fluconazole, induces vasculitis in mice. Three strains of C. krusei, NBRC1395, NBRC1162, and NBRC10737, were cultured in natural (Y) and chemically defined (C) media and cell wall mannoprotein (MN) fractions were prepared by autoclaving cells (CKY1395MN, CKC1395MN, CKY1162MN, CKC1162MN, CKY10737MN, and CKC10737MN). All MN fractions reacted strongly with Con A and dectin-2 and induced anaphylactoid shock in ICR mice. MNs induced severe coronary vasculitis in DBA/2 mice, resulting in cardiac hypertrophy. MNs also induced coronary vasculitis in C57Bl/6 mice. These results suggest that the MNs of non-albicans Candida, such as C. krusei, induce similar toxicity to those of C. albicans.

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Section: Biological and Pharmaceutical Bulletin Advance Publicationmentioning

confidence: 98%

Coronary Vasculitis Induced in Mice by the Cell Wall Mannoprotein of <i>Candida krusei</i>

Yanai

Tanaka

Miura

et al. 2020

Biological & Pharmaceutical Bulletin

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“…KD-like vasculitis can be induced in rabbit, swine, and mouse models by various methods (80)(81)(82)(83). The known genetic background and ease of genetic manipulation have made mouse models the preferred model to investigate molecular pathogenesis of KD and to discover its therapeutic targets (84)(85)(86)(87)(88).…”

Section: Insight From Experimental Studies With Animal Model For Kdmentioning

confidence: 99%

Aetiological Significance of Infectious Stimuli in Kawasaki Disease

2019

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Kawasaki disease (KD) is a pediatric vasculitis syndrome that is often involves coronary artery lesions (e. g., coronary artery aneurysms). Although its causal factors and entire pathogenesis remain elusive, the available evidence indicates that the pathogenesis of KD is closely associated with dysregulation of immune responses to various viruses or microbes. In this short review, we address several essential aspects of the etiology of KD with respect to the immune response to infectious stimuli: 1) the role of viral infections, 2) the role of bacterial infections and the superantigen hypothesis, 3) involvement of innate immune response including pathogens/microbe-associated molecular patterns and complement pathways, and 4) the influence of genetic background on the response to infectious stimuli. Based on the clinical and experimental evidence, we discuss the possibility that a wide range of microbes and viruses could cause KD through common and distinct immune processes.

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“…Ptk2b has been found acting as a negative regulator in many biological functions and consequently suggests as a potential target for some diseases through its inhibition (Lipinski & Loftus, 2010; Suzuki et al, 2017). For example, Ptk2b has been found as a new susceptibility locus of late‐onset Alzheimer's disease (AD; Chan et al, 2015; Kamboh et al, 2012; Lambert et al, 2013; Y. Q. Li et al, 2016; Lin et al, 2017), and the expression of Ptk2b increased in the brains of patients with AD (Padhy, Hayat, Nanda, Mohanty, & Alone, 2017).…”

Section: Discussionmentioning

confidence: 99%

Ptk2b deletion improves mice folliculogenesis and fecundity via inhibiting follicle loss mediated by Erk pathway

Cong

Bian

et al. 2020

Journal Cellular Physiology

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Ptk2b has been found playing critical roles in oocyte maturation and subsequent fertilization in vitro. But what is the exact in vivo function in reproduction still elusive. Here, by constructing Ptk2b mutant mice, we found Ptk2b was not essential for mice fertility, unexpectedly, contrary to previously reported in vitro findings, we found Ptk2b ablation significantly improved female fecundity. Follicle counting indicated that the number of primordial follicles and growing follicles in matured mice was significantly increased in the absence of Ptk2b, whereas the primordial follicle formation showed no defects. We also found this regulation was in an autophosphorylation independent pathway, as autophosphorylation site mutant mice (PTK2B Y402F) show no phenotype in female fertility. Further biochemistry studies revealed that Ptk2b ablation promotes folliculogenesis via Erk pathway mediate follicle survival. Together, we found a novel biological function of Ptk2b in folliculogenesis, which could be potentially used as a therapeutic target for corresponding infertility.

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Non-receptor type, proline-rich protein tyrosine kinase 2 (Pyk2) is a possible therapeutic target for Kawasaki disease

Cited by 8 publications

References 43 publications

Coronary Vasculitis Induced in Mice by the Cell Wall Mannoprotein of <i>Candida krusei</i>

Coronary Vasculitis Induced in Mice by the Cell Wall Mannoprotein of <i>Candida krusei</i>

Aetiological Significance of Infectious Stimuli in Kawasaki Disease

Ptk2b deletion improves mice folliculogenesis and fecundity via inhibiting follicle loss mediated by Erk pathway

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