Non-sentinel node tumor invasion in oropharyngeal and oral cancer: risk of misdiagnosis of metastasis

Santaolalla, Francisco; Sánchez, Juana María Brenes; Ereño, Cosme; González, Andrés; Rodríguez, María Librada Rozas; Sanchez, Alexander; Martínez, Álvaro

doi:10.1080/00016480801891710

Cited by 8 publications

(8 citation statements)

References 25 publications

(27 reference statements)

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“…In a recent work by Atula et al,12 35 patients with oral or oropharyngal SCC who had positive SN showed an overall incidence of tumor deposits in the NSN of 37% (13/35) examined at 2 mm intervals with H&E and IHC. In a prospective study of 22 patients with oral or oropharyngeal SCC T1–T3N0 who had SNB and subsequent neck dissection, Santaolalla et al13 examined the NSN by routine hilar bisectioning and H&E staining and found metastatic deposits in 4 patients (18%) who had negative or missing SN. The authors argued that these false negative results could be due to the location of tumor close to the midline and/or bilateral lymphatic drainage patterns.…”

Section: Discussionmentioning

confidence: 99%

The prevalence of occult metastases in nonsentinel lymph nodes after step‐serial sectioning and immunohistochemistry in cN0 oral squamous cell carcinoma

et al. 2011

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Section: Discussionmentioning

confidence: 99%

The prevalence of occult metastases in nonsentinel lymph nodes after step‐serial sectioning and immunohistochemistry in cN0 oral squamous cell carcinoma

et al. 2011

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“…Two authors individually collected data from included articles in forms commensurate with each other. Diagnostic accuracy, represented by DOR, summary receiver operating characteristic (SROC) curve, and area under the curve (AUC), was calculated 1,5,11–102 . DOR was calculated as (true positive [TP]/false positive [FP])/(false negative [FN]/true negative [TN]) to assess diagnostic accuracy with 95% confidence intervals (CIs).…”

Section: Methodsmentioning

confidence: 99%

Usefulness of Sentinel Lymph Node Biopsy for Oral Cancer: A Systematic Review and Meta‐Analysis

Kim

et al. 2020

The Laryngoscope

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Objective We assessed the diagnostic accuracy of sentinel lymph node biopsy (SLNB) for detecting neck nodal metastasis in early oral squamous cell carcinoma (OSCC) as an alternative to elective neck dissection. Study Design A systematic search for relevant literature was conducted in the PubMed, SCOPUS, Embase, Web of Science, and Cochrane databases. Methods Two reviewers individually searched the five databases up to November 2019. For studies that met inclusion criteria, data on patient diagnoses were pooled, including true positives, true negatives, false positives, and false negatives. Methodological quality was checked with the Quality Assessment of Diagnostic Accuracy Studies (version 2) tool. Results In total, 98 observational or retrospective studies were included. The diagnostic odds ratio of SLNB was 326.165 (95% confidence interval [CI]: 231.477–459.587; I2 = 0%). The area under the summary receiver operating characteristic curve was 0.982. Sensitivity was 0.827 (95% CI: 0.804–0.848), and specificity was 0.981 (95% CI: 0.975–0.986). The correlation between sensitivity and the false positive rate was −0.076, which indicates that heterogeneity did not exist. Subgroup analyses were performed with the subgroups reference test type, publication year, and study type. No significant difference was found within the reference test type subgroup. However, differences within the publication year and study type subgroups were significant, where the retrospective study subgroup was significantly more sensitive and specific than the prospective study subgroup. Conclusion Results of this meta‐analysis imply that the high specificity of SLNB supports its role as a diagnostic tool for patients with clinical tumor stage (CT)1‐2 clinically negative (N0) OSCC. More studies should be done to further verify the results of this study. Level of Evidence 2a Laryngoscope, 131:E459–E465, 2021

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“…SLNB uses frozen section analysis with H&E during surgery to determine the presence of metastasis in cancer. The conventional method is usually paraffin blocks followed by H&E staining to examine for possible metastasis and further immunohistochemical (IHC) [83,85,87,88,91,92,96,98,101] analysis for cytokeratin (AE1/AE3) [38,61,63,64,69,72,74,75,77,81,86] to reveal any undetected micro-metastasis if the node was free from tumors. However, the intraoperative pathology of SLNB is only moderately sensitive, and the final pathology examination might require several days.…”

Section: Tissue Biopsymentioning

confidence: 99%

A Systematic Review of Oral Biopsies, Sample Types, and Detection Techniques Applied in Relation to Oral Cancer Detection

Yang

Wei

Thong

et al. 2022

BioTech

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Background: Early identification of the stage of oral cancer development can lead to better treatment outcomes and avoid malignant transformation. Therefore, this review aims to provide a comprehensive overview that describes the development of standardized procedures for oral sample collection, characterization, and molecular risk assessment. This can help investigators to choose the appropriate sampling method and downstream analyses for different purposes. Methods: This systematic review was conducted according to the PRISMA guidelines. Using both PubMed and Web of Science databases, four independent authors conducted a literature search between 15 and 21 June 2021. We used key search terms to broaden the search for studies. Non-conforming articles were removed using an EndNote-based and manual approach. Reviewers used a designed form to extract data. Results: This review included a total of 3574 records, after eliminating duplicate articles and excluding papers that did not meet the inclusion criteria. Finally, 202 articles were included in this review. We summarized the sampling methods, biopsy samples, and downstream analysis. The biopsy techniques were classified into tissue and liquid biopsy. The common sequential analysis of tissue biopsy includes histopathological examination such as H&E or IHC to identify various pathogenic features. Meanwhile, liquid samples such as saliva, blood, and urine are analyzed for the purpose of screening to detect mutations in cancer. Commonly used technologies are PCR, RT-PCR, high-throughput sequencing, and metabolomic analysis. Conclusions: Currently, tissue biopsies provide increased diagnostic value compared to liquid biopsy. However, the minimal invasiveness and convenience of liquid biopsy make it a suitable method for mass screening and eventual clinical adoption. The analysis of samples includes histological and molecular analysis. Metabolite analysis is rising but remains scarce.

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Non-sentinel node tumor invasion in oropharyngeal and oral cancer: risk of misdiagnosis of metastasis

Cited by 8 publications

References 25 publications

The prevalence of occult metastases in nonsentinel lymph nodes after step‐serial sectioning and immunohistochemistry in cN0 oral squamous cell carcinoma

The prevalence of occult metastases in nonsentinel lymph nodes after step‐serial sectioning and immunohistochemistry in cN0 oral squamous cell carcinoma

Usefulness of Sentinel Lymph Node Biopsy for Oral Cancer: A Systematic Review and Meta‐Analysis

A Systematic Review of Oral Biopsies, Sample Types, and Detection Techniques Applied in Relation to Oral Cancer Detection

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