Non‐sequential fractional ultrapulsed CO₂resurfacing of photoaged facial skin: Preliminary clinical report

Abstract

This study evaluates results, adverse side effects and downtime of the protocol 'ActiveFX' for photodamaged facial skin. A non-sequential fractional ultrapulsed CO2 laser with specific settings is used in addition to a new computer pattern generator (CPG). From September 2006 to March 2007, 55 patients underwent this new 'soft' single-session, single-pass and full-face ablative fractional treatment. The patients were evaluated at baseline and 1 and 3 months after the treatment using a five-point scale. Seven aspects of photodamaged skin were recorded: global score, fine lines, mottled pigmentation, sallow complexion, tactile roughness, coarse wrinkles and telangiectasias. The results were compared with a non-parametric statistical test, the Wilcoxon's exact test. Eight patients received a double-pass treatment on the crow's feet regions and the improvement of the coarse wrinkles was analyzed with a quartile grading scale. Significant differences (p<0.05) between baseline and 1 and 3 months post-treatment were observed for all features except telangiectasias. Coarse wrinkles presented a good improvement only in the regions submitted to a double-pass. Minimal and isolated adverse side effects were noted and the downtime was very low. Non-sequential fractional ultrapulsed CO2 light treatment ('ActiveFX') can be considered an excellent alternative for photodamaged facial skin.

Fractional photothermolysis—an update

“…Erythema and edema are common, and desquamation may follow for several days afterward. One has to bear in mind though, that with multiple passes, the ablative damage accumulates, which increases thermal damage and consequently healing times [37]. Safety for the darkest skin types (Fitzpatrick V and VI) has yet to be determined for the fractional ablative devices.…”

“…There are considerably fewer data published on AFP, and most focus on the treatment of photodamaged skin. In a preliminary clinical report in 2007 the non-sequential fractional ultra-pulsed 10,600 nm CO 2 light treatment ActiveFX™ laser (Lumenis Inc., Santa Clara, CA, USA) was evaluated for the treatment of photodamaged facial skin [37]. Fifty-five subjects showed significant differences between baseline photographs and those taken 1-month and 3 months after treatment for all aspects of photodamaged skin (global score, fine lines, mottled pigmentation, sallow complexion, tactile roughness, coarse wrinkles) except telangiectasias.…”

Treatment of Skin Laxity Using Multisource, Phase-Controlled Radiofrequency

“…In fractional laser or skin resurfacing treatments, thermally ablated or coagulated microscopic zones from the epidermis to the dermis are spaced in a grid over the skin surface with the nonablated zones in the undamaged surrounding tissue serving as a reservoir of cells that accelerate and promote rapid healing [19]. Same principle is implemented with microneedling, as a healthy tissue reservoir assists to reduce downtime.…”

Skin Resurfacing with Carbon Dioxide Laser

“…To minimize the risk, patients should avoid sun exposure for at least 2 weeks post-procedure and are advised to use sunscreen on a regular basis for at least 30 days after treatment. Special attention should be given when treating darker skin types due to their higher risk for developing any dyschromia (Clementoni et al 2007 ). In general the use of higher fl uencies, lower density settings, and longer treatment intervals can help to decrease this potential risk.…”