Non‐skeletal Distribution of Bone‐seeking Radiopharmaceuticals

Lamb, Christopher R.

doi:10.1111/j.1740-8261.1990.tb00795.x

Cited by 15 publications

(13 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Phagocyte‐mediated fragmentation of degenerating muscle fibers peaks in 3–4 days 5 . Bone tracer uptake correlates with local tissue Ca 2+ concentration and involves adsorption to microscopic calcium and degraded macromolecules 1,26–29 …”

Section: Discussionmentioning

confidence: 99%

“…5 Bone tracer uptake correlates with local tissue Ca 2 þ concentration and involves adsorption to microscopic calcium and degraded macromolecules. 1,[26][27][28][29] The disparity in interrater agreement of focal uptake between the orthogonal views was not expected. Interrater agreement for lateral images (k ¼ 0.65) was higher than that for caudal images (k ¼ 0.26).…”

Section: Discussionmentioning

confidence: 99%

“…Though identification of increased bone turnover is the primary goal of bone phase scintigraphy, skeletal muscle injury can also cause uptake of bone-seeking radiopharmaceuticals. 1,2 Local anesthetic agents are myotoxic and can cause myofibril degeneration and myonecrosis. [3][4][5][6][7] Nerve blocks of the proximal thoracic limb have been associated with increased skeletal muscle uptake on bone phase scintigrams while no effect was seen in four horses undergoing scintigrams following nerve blocks of the distal limb.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

FOCAL SKELETAL MUSCLE UPTAKE OF 99mTECHNETIUM-HYDROXYMETHYLENE Diphosphonate FOLLOWING PERONEAL NERVE BLOCKS IN HORSES

Griffin

Young

Fosgate

et al. 2010

Veterinary Radiology &Amp; Ultrasound

View full text Add to dashboard Cite

We have observed focal skeletal muscle uptake of 99mTechnetium-hydroxymethylene diphosphonate (Tc-HDP), which could mimic a tibial lesion, in horses following peroneal nerve blocks. To characterize this observation further, 45 bone phase scintigrams were performed in 12 horses undergoing peroneal nerve blocks. Scans were performed before, and 1, 3, 7, and 14 days postblock. The superficial and deep branches of the peroneal nerve were blocked by injecting 10 ml of 2% mepivacaine in one limb and 20 ml in the other. Images were evaluated for uptake at the block site and uptake likely to mimic a tibial lesion. Regions of interest were placed over the block site and distal tibia. Count density ratios were used to estimate change in uptake intensity over time. The overall proportion affected was 0.52 (95% confidence interval [CI], 0.36-0.68; P < 0.001) 1 day postblock and 0.24 (95% CI, 0.13-0.40; P = 0.005) 3 days postblock. The overall proportion likely to mimic a tibial lesion was 0.19 (95% CI, 0.09-0.33; P < 0.001) 1 day postblock and 0.21 (95% CI, 0.09-0.40; P = 0.005) 3 days postblock. Focal skeletal muscle uptake was seen in only one horse 7 days postblock. Increased uptake intensity was associated with higher local anesthetic dose (P = 0.042). Peroneal nerve blocks cause focal skeletal muscle uptake of 99mTc-HDP on bone phase scintigraphy. This occurs in approximately 50% of blocked limbs and can mimic a tibial lesion on the lateral view in approximately 20% of blocked limbs.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

FOCAL SKELETAL MUSCLE UPTAKE OF 99mTECHNETIUM-HYDROXYMETHYLENE Diphosphonate FOLLOWING PERONEAL NERVE BLOCKS IN HORSES

Griffin

Young

Fosgate

et al. 2010

Veterinary Radiology &Amp; Ultrasound

View full text Add to dashboard Cite

show abstract

“…D ystrophic mineralization of soft tissues is a common feature in dogs with Cushing's syndrome. [1][2][3][4][5][6][7] Results from postmortem studies in dogs with Cushing's syndrome have shown that dermal mineralization occurs in 40% of the dogs and pulmonary interstitial mineralization can be detected microscopically in 90% of the dogs. 1 A previous report described a dog with idiopathic Cushing's syndrome and interstitial pulmonary mineralization.…”

mentioning

confidence: 99%

“…6 Additionally, pulmonary uptake of 99m Tc-methylene diphosphonate ( 99m Tc-MDP) in a dog with Cushing's syndrome has been described. 7 Four dogs with pituitary-dependent hyperadrenocorticism (PDH) and pulmonary interstitial mineralization based on thoracic radiographic changes or delayed bone phase scintigraphy using 99m Tc-MDP with normal pulmonary 99m Tc-macro-aggregated albumin ( 99m Tc-MAA) perfusion scintigrams have been described. 8 In the 2 dogs studied with 99m Tc-MDP, the intensity of uptake was greater than surrounding bone uptake.…”

mentioning

confidence: 99%

Frequency of Pulmonary Mineralization and Hypoxemia in 21 Dogs with Pituitary-Dependent Hyperadrenocorticism

et al. 2000

View full text Add to dashboard Cite

The purpose of this study was to determine the frequency of hypoxemia and pulmonary mineralization using 99mTc-methylene diphosphonate (99mTc-MDP) in dogs with pituitary-dependent hyperadrenocorticism (PDH). Twenty-one dogs with PDH were prospectively evaluated using thoracic radiography, arterial blood gas analysis, and bone phase and pulmonary perfusion scintigraphy (using 99mTc-macro-aggregated albumin [99mTc-MAA]). The radiographs and bone and perfusion studies were evaluated subjectively. An averaged quantitative count density ratio was calculated between the thorax and cranial thoraco-lumbar vertebrae from lateral thoracic 99mTc-MDP images. Thoracic:vertebral ratios were calculated using 99mTc-MDP studies from 21 control dogs. The thoracic:vertebral ratios were compared between the 2 groups (PDH and control). The mean age (+/-SD) of the 21 PDH dogs was 10.2 (+/-3) years, whereas the mean age of the control group was 9.8 (+/-3) years. Seven of the 21 dogs with PDH were hypoxemic (defined as an arterial partial pressure of oxygen [PaO2] < 80 mm Hg) with an average PaO2 (+/-SD) of 62 (+/-15) mm Hg. Of the 7 hypoxemic dogs, 2 were found to have pulmonary mineralization based on bone scintigraphic images. Pulmonary perfusion abnormalities were not identified using 99mTc-MAA in any of the 21 PDH dogs. Six PDH dogs had an abnormal interstitial pulmonary pattern and 5 of these dogs were hypoxemic. The average quantitative thoracic:vertebral ratio was not significantly different between the PDH and control dogs (0.5 +/- 0.4 versus 0.4 +/- 0.1, P = .16). Causes of hypoxemia other than pulmonary thromboembolism should be considered in dogs with PDH. Pulmonary mineralization may contribute to hypoxemia in dogs with PDH.

show abstract