2001
DOI: 10.1074/jbc.c100140200
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Non-small Cell Lung Cancer Cyclooxygenase-2-dependent Invasion Is Mediated by CD44

Abstract: Elevated tumor cyclooxygenase (COX-2) expression is associated with increased angiogenesis, tumor invasion, and suppression of host immunity. We have previously shown that genetic inhibition of tumor COX-2 expression reverses the immunosuppression induced by nonsmall cell lung cancer (NSCLC). To assess the impact of COX-2 expression in lung cancer invasiveness, NSCLC cell lines were transduced with a retroviral vector expressing the human COX-2 cDNA in the sense (COX-2-S) and antisense (COX-2-AS) orientations.… Show more

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Cited by 218 publications
(172 citation statements)
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“…Overexpression of the inflammatory mediator COX-2 in tumors is associated with angiogenesis, enhanced invasion and metastasis [85][86][87][88]. Exposure to PGE2 has been shown to upregulate the transcription factor Snail in NSCLC, as have the cytokines TGF-β and interleukin-6 in other tumor types [40,89].…”
Section: The Inflammatory Tme Contributes To Angiogenesismentioning
confidence: 99%
“…Overexpression of the inflammatory mediator COX-2 in tumors is associated with angiogenesis, enhanced invasion and metastasis [85][86][87][88]. Exposure to PGE2 has been shown to upregulate the transcription factor Snail in NSCLC, as have the cytokines TGF-β and interleukin-6 in other tumor types [40,89].…”
Section: The Inflammatory Tme Contributes To Angiogenesismentioning
confidence: 99%
“…4A). Pretreatment of A549 and H1299 cells with various concentrations of GSPs (20,40, or 60 μg/mL) for 48 hours resulted in a dose-dependent inhibition of this PGE 2 -induced cell proliferation (Fig. 4A).…”
Section: Gsps Inhibit Pge 2 -Induced Cell Proliferation Of Nsclc Cellsmentioning
confidence: 99%
“…These data suggest that the stimulation of PGE 2 receptor in lung cancer cells has a role in cell proliferation, and that GSPs inhibit the NSCLC cell proliferation, at least in part, by inhibiting the levels of PGE 2 receptor. (20,40, or 60 μg/mL) before the addition of PGE 2 (10 μmol/L) for 48 h. Cells were harvested and proliferation was determined using the MTT assay. B, A549 and H1299 cells were treated with PGE 2 (10 μmol/L), indomethacin (40 μmol/L), or various concentrations of GSPs.…”
Section: An Ep4 Agonist Enhances the Proliferation Of Lung Cancer Celmentioning
confidence: 99%
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“…A recent study implicates COX-2 overexpression as a proximal mediator of CD44-dependent invasion in human non-small cell lung cancer and in human renal carcinoma cells (27,28). Cox-2 and CD44v (23,24,29) are overexpressed in carcinogen-induced tumors, and our recent study demonstrates that HA-CD44 interactions constitutively regulate COX-2-induced cell survival in normal epithelial cells and colon carcinoma cells (30,31).…”
mentioning
confidence: 99%