2020
DOI: 10.3390/jcm9061870
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Non-Small Cell Lung Cancer from Genomics to Therapeutics: A Framework for Community Practice Integration to Arrive at Personalized Therapy Strategies

Abstract: Non-small cell lung cancer (NSCLC) is a heterogeneous disease, and therapeutic management has advanced with the identification of various key oncogenic mutations that promote lung cancer tumorigenesis. Subsequent studies have developed targeted therapies against these oncogenes in the hope of personalizing therapy based on the molecular genomics of the tumor. This review presents approved treatments against actionable mutations in NSCLC as well as promising targets and therapies. We also discuss the current st… Show more

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Cited by 20 publications
(18 citation statements)
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References 187 publications
(280 reference statements)
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“…Thus, building the workflow infrastructure to support the use of pathway tools which include increasingly higher cost therapies can also support more timely authorization of treatments for patients and can help to engage early patient assistance, when needed, so patients can receive timely care which improves outcomes [ 46 , 47 ]. Several examples of the growing complexity of high-quality care are described in companion articles on colorectal and non-small cell lung cancer by colleagues in this series [ 48 , 49 ].…”
Section: Nccn Guidelines and Growing Complexity Of Evidence-based mentioning
confidence: 99%
“…Thus, building the workflow infrastructure to support the use of pathway tools which include increasingly higher cost therapies can also support more timely authorization of treatments for patients and can help to engage early patient assistance, when needed, so patients can receive timely care which improves outcomes [ 46 , 47 ]. Several examples of the growing complexity of high-quality care are described in companion articles on colorectal and non-small cell lung cancer by colleagues in this series [ 48 , 49 ].…”
Section: Nccn Guidelines and Growing Complexity Of Evidence-based mentioning
confidence: 99%
“…Current therapeutics, such as surgery, chemotherapeutic agents, and targeting and immune therapies, have significantly improved the survival rate of patients with lung cancer. However, most patients diagnosed in the advanced metastatic stage still have a very low overall survival rate (2). Thus, developing novel effective targeted treatments is a crucial step in lung cancer therapy (3).…”
Section: Introductionmentioning
confidence: 99%
“…Lung cancer remains one of the fatal causes of cancer related malignancies in the world with non-small cell lung cancer (NSCLC) accounting for 85% of cases [ 1 ]. NSCLC encompasses numerous subtypes, including lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) and despite advances in diagnosis, 70% of patients present with metastatic lung cancer disease when surgery is not an option [ 2 ]. Receptor tyrosine kinases (RTKs) have emerged as critical players of cellular communication function and network.…”
Section: Introductionmentioning
confidence: 99%