Non-small cell lung cancer: the new T1 categories

Abstract

Recently, major changes have occurred in the staging, diagnosis, and treatment of early stage lung cancer. By screening high-risk populations, we are now able to detect lung cancers at an early stage, but the false-positive rate is high. A new pathological classification was published in 2011 and fully incorporated in the 2015 World Health Organisation (WHO) Classification of Tumours of the Lung, Pleura, Thymus, and Heart. The new eighth edition of the tumour–node–metastasis (TNM) staging system has been fully published and will be in use from January 2017. T1 lesions are subdivided into T1a, T1b, and T1c lesions corresponding to lung cancers up to 10 mm, between 11 and 20 mm, and between 21 and 30 mm, respectively. To determine the size, only the solid part on computed tomographic scanning of the chest and the invasive part on pathological examination will be considered. Prognosis is significantly better for the smallest lesions. For some specific subgroups, sublobar resection may be oncologically valid and yield good long-term outcome, but the results of recently performed randomised trials are awaited.

Ensuring the Safety and Security of Frozen Lung Cancer Tissue Collections through the Encapsulation of Dried DNA

“…Among these small-sized tumors, the patients who relapse two and five years after surgery and those who did not relapse at least five years after surgery were identified. At present one of the major issues in thoracic oncology is to define novel biomarkers that predict the evolution of lung cancers of small size [ 42 , 43 , 44 , 45 , 46 , 47 ]. In fact, in the future adjuvant treatments could probably be proposed to patients with tumors with a biological signature indicative of poor prognosis [ 48 ].…”

Bronchoscopic procedures to diagnose peripheral lung lesions

“…Hvis PET-CT er uden tegn til metastasering, er biopsi direkte fra det perifere lungeinfiltrat nødvendig for at fastslå tilstedevaerelse og type af kraeft [1,2]. Lungecancere under 10 mm har den største femårsoverlevelse efter kurativ behandling [3]. Biopsi kan foretages bronkoskopisk, perkutant (transtorakal nålebiopsi) eller ultimativt ved kirurgisk fjernelse af infiltrat og omgivende lungevaev (f.eks.…”