Non-small cell lung cancer with single brain metastasis: the role of surgical treatment

Granone, Pierluigi; Margaritora, Stefano; D’Andrilli, Antonio; Cesario, Alfredo; Kawamukai, Kenji; Meacci, Elisa

doi:10.1016/s1010-7940(01)00744-8

Cited by 60 publications

(55 citation statements)

References 26 publications

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“…In good performance status (PS) patients with solitary BM and otherwise controlled systemic disease, surgical resection of the BM is a valuable treatment option [8][9][10]. Generally, surgical resection of BM is the preferred treatment in case of larger or symptomatic lesions or with a location in the vicinity of a vulnerable area.…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of histology after resection of brain metastases and whole brain radiotherapy in non-small cell lung cancer (NSCLC)

Putora

Ess

Panje

et al. 2015

Clin Exp Metastasis

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Brain metastases from non-small cell lung cancer (NSCLC) are associated with a poor prognosis. In selected cases, surgical resection of brain metastases may be indicated, but the identification of patients suitable for surgery remains difficult. We collected data on patient and tumour characteristics known or suspected to be associated with survival by chart review. Data was merged with available data from the local cancer registry. We identified 64 NSCLC patients with resected brain metastases. Median overall survival after resection was 9.1 months with only two patients (3%) surviving more than 71 and 80 months. One and 2-year survival were 42 and 12.5%. Median survival for males and patients with more comorbidities was shorter (8 vs. 10 months [p = 0.11] and 6 vs. 9 months [p = 0.06]). Patients with squamous cell carcinomas (33% of the patients) had a significantly worse survival than patients with other histologies (7 vs. 10 months [p = 0.02]) with no patient living longer than 2 years. Squamous cell histology was associated with worse prognosis after resection of brain metastases in patients with non-small cell lung cancer. Histology, among other parameters, may also be taken into account when choosing the appropriate patients for resection of brain metastases.

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Section: Introductionmentioning

confidence: 99%

Prognostic significance of histology after resection of brain metastases and whole brain radiotherapy in non-small cell lung cancer (NSCLC)

Putora

Ess

Panje

et al. 2015

Clin Exp Metastasis

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“…Specifically, despite there being no statistical significance, there was a serious propensity (p<0.1) for patients with adenocarcinoma to have improved survival compared to patients with other histological types. Bonnette and Granone reported similarly favorable results in terms of survival for adenocarcinomatous tumor pathology (12,13). In other retrospective studies, however, the prognostic value of primary tumor histology was shown not to be statistically significant (5,8,10,11,14,15,(19)(20)(21).…”

Section: Discussionmentioning

confidence: 83%

Surgical Management of Non-small Cell Lung Cancer with Solitary Hematogenous Metastases

Karagkiouzis

Spartalis²,

Moris

et al. 2017

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Abstract. Background Stage IV disease at initial presentation accounts for approximately 41% of newly-diagnosed cases with non-small cell lung cancer (NSCLC) (1). Prognosis for metastatic lung cancer remains dismal, despite continuously emerging treatment options. Although the majority of patients have disseminated metastatic disease at diagnosis, a small percentage are found to have a solitary metastasis. In addition any patients with NSCLC who previously received definitive treatment may experience metachronous solitary distant recurrence during the course of their disease. This poorly understood state of limited metastatic load has been described as oligometastatic disease and it seems to run a more indolent course (2, 3). Retrospective clinical studies focused on the surgical management of solitary extrapulmonary metastases, have reported favorable results (4).The aim of this retrospective study was to review our experience with patients who underwent resection of primary NSCLC and solitary extrapulmonary metastasis, and to analyze prognostic factors affecting survival. Patients and MethodsWe reviewed the medical records of thoracic surgical Departments at Laikon General Hospital of Athens and Sotiria Hospital for Chest Diseases (former Second Department of Thoracic Surgery) from January 2004 to December 2012 for patients with NSCLC having undergone combined resections (including stereotactic radiosurgery) of primary lung tumor and solitary hematogenous metastasis.

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“…3 Studies have been performed on the effect of neurosurgery for brain metastasis in the patients with neurological symptoms on diagnosis; however, their results were limited to patients with a solitary metastasis. [13][14][15][16] We performed early surgical treatment of brain metastasis (including multiple metastases) in patients with lowered performance status (i.e., KPS <70 or RPA class II or III) (Table 1). Early surgical treatment controlled the progression of brain metastasis and improved neurologic symptoms, and was followed by better performance status that enabled systemic chemotherapy (Fig.…”

Section: Neurological Function Scorementioning

confidence: 99%

“…15,16 Advances in surgical techniques have led to lower rates of morbidity and in-hospital mortality, with estimates as low as 1.8% in high-volume centers. 17 However, in the case of multiple brain metastases, surgery is usually limited to patients with a dominant, symptomatic, or life-threatening lesion and to those who require a tissue diagnosis before proceeding with therapy.…”

mentioning

confidence: 99%

Efficacy of Surgical Treatment for Brain Metastasis in Patients With Non-small Cell Lung Cancer

Byun

Chung

2014

Chest

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Non-small cell lung cancer with single brain metastasis: the role of surgical treatment

Abstract: We can conclude that combined surgical therapy is, nowadays, the choice treatment for this kind of patients, even though restricted to selected cases. The knowledge of prognostic factors may optimize indications for surgery.

Cited by 60 publications

References 26 publications

Prognostic significance of histology after resection of brain metastases and whole brain radiotherapy in non-small cell lung cancer (NSCLC)

Prognostic significance of histology after resection of brain metastases and whole brain radiotherapy in non-small cell lung cancer (NSCLC)

Surgical Management of Non-small Cell Lung Cancer with Solitary Hematogenous Metastases

Efficacy of Surgical Treatment for Brain Metastasis in Patients With Non-small Cell Lung Cancer

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