Non-specific Cellular Immunity in Type I and Type II Diabetes

Fövényi, J; Tótpál, Klára; Thaisz, E; Garam, T

doi:10.1055/s-0029-1210332

Cited by 5 publications

(3 citation statements)

References 3 publications

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“…Our results affirms few other previous studies, which reported that the phagocytic activity of peripheral blood mononuclear cells is impaired in type 2 DM subjects (14,18,19). However, there are no conclusive reports that address the responsiveness of neutrophils of DM patients to treatment targeting glycemic control (14,19,20).…”

Section: Discussionsupporting

confidence: 90%

“…Our findings reinforce the concept that hyperglycemia has an impact on immune deficits in DM patients which in turn imparts effect on the functions of the neutrophils. Therefore DM patients in whom hyperglycemia is not controlled for long periods can be predisposed to progressive deleterious effects on the immune dysfunctions (9,20). Immune dysfunctions in these patients impact neutrophil phagocytic functions and dysfunctional neutrophil functions increasing their risk for severe infections, microvascular and macrovascular complications (21)(22)(23).…”

Section: Discussionmentioning

confidence: 99%

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Phagocytic and oxidative burst activity of neutrophils in type 2 diabetic patients with foot ulcers

et al. 2021

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Introduction and Aim: Diabetic foot ulcers are common complications seen in diabetic patients. Treatment of this disabling foot sore remains a challenge to health care professionals. This study aimed at evaluating whether the neutrophils from type 2 diabetic patients with foot ulcers present an impairment of phagocytic index and impairment in respiratory burst. We also aimed at understanding whether the impairment in neutrophil phagocytic activity can be alleviated with short course of standard treatment regime for foot ulcers. Methodology: For this case-controled study, 43 participants with type 2 diabetes (18 with foot ulcers and 25 without foot ulcers) were prospectively recruited along with 18 healthy volunteers. Phagocytic activity of neutrophils and respiratory burst of neutrophils was assessed along with ESR, percentage neutrophil counts before and after 2 weeks of standard treatment for foot ulcers. Results: Neutrophils of type 2 diabetic patients (with and without foot ulcers ) showed lower levels of phagocytic index and lower percentage of respiratory burst on comparison with non-diabetic subjects. Furthermore, on receiving treatment for foot ulcers, a significant improvement in neutrophil phagocytic indices were observed, along with improvement in wound ulcer score. Conclusion: Phagocytic activity of the neutrophils is impaired in type 2 diabetics (with and without foot ulcers). Neutrophil phagocytic indices can be improved on glycemic control. Additionally, improvement in neutrophil phagocytic indices after short course treatment for foot ulcers can be useful markers to predict treatment efficacy and in prognosis of diabetic foot ulcers.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Phagocytic and oxidative burst activity of neutrophils in type 2 diabetic patients with foot ulcers

et al. 2021

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“…15 It is also thought that deranged immunity in diabetic individuals may also originate from antibody dependant cellular cytotoxic responses, which target insulin. 16 Elevated ADA in diabetic patients may associate with the insulin resistance. Insulin acts on peripheral tissues to stimulate glucose transport and metabolism and inhibit gluconeogenesis.…”

Section: Resultsmentioning

confidence: 99%

Adenosine Deaminase Activity in Type 2 Diabetes Mellitus

Peruvankuzhiyil¹,

Madhavan²,

Joseraj³

2017

jebmh

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BACKGROUND Altered blood levels of adenosine deaminase may help in predicting immunological dysfunction in diabetic individuals. But very few studies exist on ADA activity in type 2 diabetes mellitus. Aim of this study is to compare serum adenosine deaminase activity in type 2 diabetic patients with non-diabetic control. MATERIALS AND METHODS A comparative study design was used in data collection process. The study was conducted in 40 type 2 diabetes mellitus patients attending diabetic clinic or admitted in the medicine ward for metabolic control of diabetes in medical college, Calicut from January 2011 to January 2012. The adenosine deaminase (ADA) level in the serum is measured by endpoint method in these patients. The results were expressed as mean and standard deviation. The statistical significance of the differences between the values was assessed by ANOVA. RESULTS Among 40 diabetic patients, mean ADA level in the serum is 38.56, SD±6.72 (min 30, max 53). Mean ADA level in the serum in the control group is 22.04±4.625 (min 13, max 29). CONCLUSION ADA level in the serum is found to be increased indicating its role as an important immunoenzyme marker in the aetiopathology of type 2 diabetes mellitus.

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